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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	298-07-7
Chemical Name	Bis(2-ethylhexyl) hydrogen phosphate
Substance ID	24A6101
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point is 198 deg C [closed-cup] (HSDB (2006)) above 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 300 deg C (GESTIS (Access on Aug. 2012)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metalloid (P) present in the molecule, but because there is the information that it is not reactive with water (Renzo (3rd, 1986)), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, it is described that it is mildly corrosive to most metals (HSDB (2006)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Two LD50 values for rats of 4,940 mg/kg bw (ECETOC JACC 20 (1992)), 1,400 mg/kg (HPVIS (2009)) were obtained, one corresponds to "Not classified" (corresponding to Category 5 in UN GHS classification), and the other corresponds to Category 4. Therefore, from a safety point of view, the category with higher hazard was adopted, and it was classified in Category 4.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	It was classified in Category 4 based on an LD50 value of 1,250 mg/kg bw for rabbits (ECETOC JACC 20 (1992)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Data are lacking. Besides, it is described that no deaths or symptoms were observed as a result of 8-hour exposure to the saturated vapour of this substance in rats (BUA 172 (1995)).
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It was classified in Category 1 because it was corrosive in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 1-8 hours (USEPA/HPV (2001)), it was highly irritating and the primary dermal irritation index (PDII) was 6.2 in another test by a 24-hour occlusive application of 0.5 mL of undiluted this substance to rabbits (HPVIS (2009)). Besides, in tests with rabbits other than the above tests, it is also reported that PDII was 0, and it was not irritating after a 24-hour occlusive application of 0.5 mL, and PDII was 4.85, it was irritating but not corrosive after a 48-hour occlusive application (HPVIS (2009)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was classified in Category 1 because it was judged as corrosive in an eye irritation test in which 100 microL of this substance was applied to rabbits (USEPA/HPV (2001)), all the total mean scores (equivalent to AOI) were 98 or above (110 being the most severe) at 1, 2, 3, and 7 days after the application, and it was judged as corrosive in another eye irritation test with six rabbits (Federal Register) (HPVIS (2009)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there are reports on a negative result in an Ames test (ECETOC JACC 20 (1992)) and a negative result in a mouse lymphoma test (HPVIS (2009)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	In an acute toxicity test in which 500-3,000 mg/kg was orally administered to rats (LD50: 1,400 mg/kg), depression and deaths were observed in all dose groups, but a necropsy revealed no gross alterations related to exposure (HPVIS (2009)). And in an acute toxicity test in which 500 or 5,000 mg/kg was orally administered to rats (10 animals/group), all animals died after administration of 5,000 mg/kg, there were no deaths after administration of 500 mg/kg, and general signs in survivors (500 mg/kg dose group) were limited to nasal discharge and diarrhea (HPVIS (2009)). Despite the above reports, the details of effects at doses within the guidance value range are unknown, therefore it was classified as "Classification not possible" due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 15 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 9.3 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)) although it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 0-17% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1985)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0-17% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1985)), and 48-hour EC50 = 15 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)). By drawing a comparison between the above results, it was classified in Category 3.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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