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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10025-82-8
Chemical Name	Indium(III) chloride
Substance ID	24A6136
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	- -	-	-	It was classified as "Not classified" from the information that it is not combustible (ICSC (J) (2001)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" from the information that it is not combustible (ICSC (J) (2001)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It was classified as "Not classified" from the information that it is not combustible (ICSC (J) (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metal (In) present in the molecule, but from data: water solubility of 212 g/100 mL (Lange (16th, 2005)), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an inorganic compound containing halogen (Cl), but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It is described that no evidence of irritation was found in a test by an application to the human skin (PATTY (6th, 2012)), but because the test details are unknown, it was classified as "Classification not possible."
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	It is described that no skin sensitization was observed in a patch test by an application of this substance to human volunteers (PATTY (6th, 2012)), but because the test details such as the test methods and positive rate are unknown, it was classified as "Classification not possible" due to lack of data.
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 based on a positive result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (PATTY (6th, 2012)). Besides, there is a description suggesting that it was positive in a dominant lethal test (PATTY (6th, 2012)), but the test details such as test animals and an administration route are unknown. And as for in vitro tests, it was reported to be positive in a micronucleus test with Chinese hamster CHO cells (PATTY (6th, 2012)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	This substance was classified in Category 2 because it is included in the target substances in "the technical guidance for preventing health impairment of workers engaged in indium tin oxide handling processes." And IARC classified indium phosphide in Group 2A for carcinogenicity, and its carcinogenicity was considered to be due to indium, although the carcinogenicity of indium compounds other than indium phosphide is unknown. Besides, after 104-week exposure to ground powders of indium tin oxide (ITO) at concentrations of 0.01, 0.03, 0.1 mg/m3 in male and female rats, an increase in the incidence of lung tumors including malignant tumors was observed at a minimal concentration of 0.01 mg/m3, but there was no carcinogenicity in mice.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Malformations, mainly in tails and digits, as well as deaths significantly increased in fetuses in a test by intravenous administration to rats on a gestational day 9, but no malformations were observed after oral administration (OEL Documentations Vol. 49 (Japan Society For Occupational Health (JSOH), 2007)). And malformations such as brachyury, kinked tail, cleft palate, and oligodactyly were found in a test by intravenous administration to rats on a gestational day 9, 10, or 11, but no malformations occurred in mice, and only an increase in fetal death was seen (PATTY (6th, 2012)). Furthermore, in a test in which male and female rats were orally dosed at or below 250 mg/kg/day and mated during a 21-day treatment period, there were no effects on male fertility and liver function, and there were no fertility effects in females, but intrauterine fetal deaths increased, which were considered to be due to decreased body weights (OEL Documentations Vol. 49 (Japan Society For Occupational Health (JSOH), 2007)). From the above, for rats, malformations that were not observed afte
8	Specific target organ toxicity - Single exposure	Category 1 (lung)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In a test with rats by 1-hour inhalation exposure to the aerosol of this substance (doses: 0.2, 2.0, 20 mg/m3), restrictive lung lesions and increased airway sensitivity to acetylcholine were observed in direct proportion to the lung disturbances at seven days after exposure, and lung collagen concentrations after 42 days increased dose-dependently to the exposure concentrations. Because it is reported that the results showed that exposure to this substance was a cause of acute pneumonia (OEL Documentations Vol. 49 (Japan Society For Occupational Health (JSOH), 2007)), and the test doses (converted 4-hour equivalent value: 0.00005, 0.0005, 0.005 mg/L) correspond to the guidance value range for Category 1, it was classified in Category 1 (lung).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is reported that this there were growth delays for a diet mixed with 2.4% or 4% in a test by 3-month feeding a diet mixed with this substance (OEL Documentations Vol. 49 (Japan Society For Occupational Health (JSOH), 2007)), and it is reported that after subcutaneous administration of this substance to male hamsters (1.5 mg/kg, 0.78 mg In/kg) (3 times/week, 4 weeks), there were decreases in erythrocyte ALAD activity and kidney ALAD activity, and the excretion of ALA and protoporphyrin fraction in the urine increased (OEL Documentations Vol. 49 (Japan Society For Occupational Health (JSOH), 2007)), However, it was classified as "Classification not possible" due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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