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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7646-78-8
Chemical Name	Stannic chloride
Substance ID	H26-B-058, R-024
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It reacts violently with water and moisture and produce hydrogen chloride (ICSC (2004)), which is not a combustible gas, therefore, it was classified as "Not classified."
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing halogen, but the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, there is information that it attacks many metals (ICSC (2004)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Since this substance may react with water to generate a hydrochloric acid mist, please also refer to the classification result of hydrochloric acid (CAS RN: 7647-01-0). Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the report of an LC50 value (4 hours) of 1.35 mg/L (=131 ppm) for rats for the vapor of this substance (vehicle: air with relative humidity >= 50%) (SIDS (2009)), it was classified in Category 2. Besides, since the LC50 value is lower than 90% of the saturated vapor concentration (23,692 ppm), the reference value in units of ppm was applied as a vapor without a mist. Moreover, in this report, there is a description (Test substance vapor formed a white cloud in contact with the humidified air) indicating that hydrogen chloride is generated by the reaction of this substance with moisture in the air as the vehicle. Based on this high-priority new information source (SIDS (2009)), the category was revised.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a report that in a skin irritation test in which this substance was applied to rabbits for 1 or 4 hours (OECD TG 404), it showed corrosion (primary irritation score is unknown) (SIDS (2009)). In addition, there is a report that in a skin irritation test with rats, it is irritating to the skin at or above the concentration of 5% of this substance (SIDS (2009)). From the above results, it was classified in Category 1. Besides, this substance is classified as "C; R34" in EU DSD, and as "Skin Corr. 1B H314" in EU CLP.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation test in which 0.1 mL of undiluted liquid of this substance was applied to rabbit eyes (washed or non-washed after 20 seconds), moderate to severe corneal opacity, moderate iris hyperemia and moderate conjunctival redness were observed in the washed group. Severe corneal opacity and extreme conjunctival whiteness were observed in the non-washed group (SIDS (2009)). In addition, eye closure was observed until 14 days later in the washed and the non-washed eye groups. From the above results, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report that in a sensitization test in which this substance was applied to rats, no sensitization was observed (SIDS (2009)). However, since it is not a test method according to the guidelines and the details of the results and others are unknown, the data were judged insufficient for use in classification.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and positive in a chromosome aberration test, a micronucleus test and a sister chromatid exchange test with cultured mammalian cells (SIDS (2009), ATSDR (2005), CICAD 65 (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Inorganic tin compounds are irritating to the mucosa (ATSDR (2005), HSDB (Access on July 2014)). There is a report of labored respiration, gasping, nasal and oral discharge, reduced response to noise and wet fur at 0.29-3.08 mg/L vapor by inhalation exposure to rats (SIDS (2009)). Since this substance was judged irritating to the respiratory tract from the above, it was classified in Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In an epidemiological survey of 267 workers in a glass bottle manufacturing plant, respiratory symptoms such as wheezing, cough, chest pain and dyspnea occurred in workers exposed to fumes of this substance, the reason of which was considered to be the respiratory tract irritation by exposure to hydrogen chloride formed in the process of mixing this substance with water on heating (SIDS (2009), CICAD 65 (2005)). Therefore, since respiratory tract symptoms were expected to occur by inhalation of hydrogen chloride derivatively formed by hydrolysis of this substance in the workplaces handling this substance, it was classified in Category 1 (respiratory organs). In addition, there are reports that stannic oxide (IV), which is formed simultaneously by hydrolysis, causes pneumoconiosis (stannosis) in humans (SIDS (2009), ATSDR (2005)), and this also corresponds to Category 1 (respiratory organs). On the other hand, in experimental animals, although there are no findings on exposure to this substance, histopathological changes in the nasal cavity were observed in rats and mice that inhaled hydrogen chloride mist for 90 days (SIDS (2009)). Besides, as for stannous chloride (ID: 56; CAS RN: 7772-99-8), a related substance, it was considered that no respiratory tract effects occur in humans because it is unlikely to generate "hydrogen chloride or hydrochloric acid" or "stannous oxide (II)" by reaction with moisture in the air, unlike this substance. However, based on the findings on experimental animals through the oral route, the liver, kidney and hemal system were adopted as the target organs. On the other hand, there were no experimental animal data for this substance, so it was impossible to identify the target organs. Therefore, the classification results were different between the two substances (refer to the classification results of stannous chloride (ID: 56; CAS RN: 7772-99-8)).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	This substance readily decomposes in water and produces hydrochloric acid, pH drop by which is thought to cause effects to aquatic organisms. Because it is described that crustacea (Daphnia magna) is one of the most sensitive species from the results of tests using hydrochloric acid (SIDS, 2002), and the minimum concentration of hydrolyzed SnCl4 that would result in a similar pH/concentration of aqueous HCl, assuming complete hydrolysis, would be about 8.8 mg SnCl4/L in an unbuffered solution (SIDS, 2007), it was classified in Category 2.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified in Category 2 in acute toxicity, but it is estimated to be largely due to a drop of pH by hydrochloric acid produced, and it was judged to be inappropriate to use the classification result in acute toxicity for classification in chronic toxicity. Therefore, it was classified as "Classification not possible."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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