Item | Information |
---|---|
CAS RN | 115-90-2 |
Chemical Name | Phosphorothioic acid O,O-diethyl O-(4-methylsulfinylphenyl) (fensulfothion) |
Substance ID | H26-B-062, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility of 0.15 g/100 mL (25 deg C) (ICSC (2001)) were obtained, it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 1 |
Danger |
H300 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
There are multiple LD50 values for rats, 10.5 mg/kg (male) (ACGIH (7th, 2005)), 1.8-2.3 mg/kg (female), 3.96-10.5 mg/kg (male) (JMPR (1972)), 1.8-10.2 mg/kg (PATTY (5th, 2001)) and 3.5 mg/kg (PIM G001 (1998)). According to the GHS Classification Guidance for the Japanese government, it was classified in Category 1 to which most of the reports correspond. |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 |
P302+P352
P262 P264 P270 P280 P310 P321 P361 P364 P405 P501 |
Based on the reports of LD50 values of 3.5 mg/kg (female), 4.1 mg/kg (female), 19 mg/kg (male), 30.0 mg/kg (male) (ACGIH (7th, 2005)), 3.5-13 mg/kg (female), 14-30 mg/kg (male) (JMPR (1972)) for rats, it was classified in Category 1. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on the reports of LC50 (4 hours) values of 0.0295 mg/L (ACGIH (7th, 2005), PATTY (5th, 2001)) and 0.030 mg/L (JMPR (1972)) for rats, it was classified in Category 1. Besides, since LC50 values were higher than the saturated vapor concentration (0.000832 mg/L), the reference value of the mist was applied. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there is a description that in humans this substance may show skin irritation in contact with skins (HSDB (Access on July 2014)), because it is a general description, it was not adopted for classification. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there is a description that organophosphorus pesticides cause chronic conjunctivitis and keratitis in contact with the eyes (HSDB (Access on July 2014)), because it is a general description, it was judged to be insufficient data for classification. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test (JMPR (1982), HSDB (Access on August 2014)). As for in vitro, it was negative in a bacterial reverse mutation test and a sister chromatid exchange test with cultured mammalian cells (JMPR (1982), ACGIH (7th, 2005), HSDB (Access on August 2014)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - |
Since it is classified as A4 by ACGIH (ACGIH (7th, 2005)), it was classified as "Classification not possible." The classification was revised due to the change in the GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Not classified |
- |
- | - | It is reported that there were no effects on fertility of the parents and on development and growth of pups in a three-generation reproductive toxicity study by feeding with mice, that there were no teratogenicity in the teratogenicity studies by oral administration (feeding or gavage) with rabbits, and that no effects on fertility were observed in a reproductive toxicity study by inhalation with rats (ACGIH (7th, 2005), JMPR (1972) JMPR (1982)). Therefore, it was classified as "Not classified." |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory organs) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
This substance has a cholinesterase inhibiting effect (ACGIH (7th, 2005), HSDB (Access on August 2014)). In humans, it is reported that bradycardia, hypotension, seizures, convulsion, respiratory insufficiency, weakness, coma were seen in oral or dermal exposure, and though the route of exposure was not described, nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, convulsions, disorientation, miosis, weakness, paralysis, coma, dyspnea, rale, bronchorrhea, bronchospasm, tachypnea, respiratory insufficiency, chemical pneumonitis, and as a severe case, non-cardiogenic pulmonary edema are observed (ACGIH (7th, 2005), HSDB (Access on August 2014)). In experimental animals, oral administration of 550 mg/kg to rats caused loss of righting ability (ACGIH (7th, 2005)). From the above, since effects on the nervous system and respiratory organs are seen in humans, it was classified in Category 1 (nervous system, respiratory organs). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There are no hazard findings in humans. In experimental animals, in each study in which the substance was administered by feeding to rats for 17 months and to dogs for 12 weeks or 2 years, serum, red blood cell, and brain cholinesterase activities were inhibited from concentrations of 1-2 ppm (corresponding to 0.025-0.05 mg/kg/day) in feed, and at the higher dose (5 ppm), cholinergic poisoning symptoms (although there is no specific description, it is speculated that miosis, tremor, convulsions, etc. were observed), weight loss and mortality occurred (JMPR (1972), ACGIH (7th, 2005)). In addition, in a study in which rats were exposed to this substance (presumed to be the mist) by inhalation for 12 weeks, inhibition of cholinesterase at 0.818 mg/m3 (0.00076 mg/L/6 hours), and poisoning symptoms, weight loss and mortality at 7.21 mg/m3 (0.0067 mg/L/6 hours) occurred (JMPR (1982), ACGIH (7th, 2005)). From the above, in experimental animals through both the oral and inhalation routes, neurotoxicity due to cholinesterase inhibition occurred from doses within the range of Category 1, and in severe cases, death was shown. Therefore, it was classified in Category 1 (nervous system). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|