GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 7699-43-6 |
| Chemical Name | Zirconium oxychloride |
| Substance ID | H27-B-074/C-119B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2015)). |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2015)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2015)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from the observation result that it is soluble in water (GESTIS (Access on September 2015)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen and halogen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value for rats of 3,500 mg/kg (HSDB (Access on September 2015)), this substance was classified as "Not classified" (Category 5 in UN GHS classification). |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that since this substance hydrolyzes to form hydrochloric acid, irritation may be seen on contact with the skin (PATTY (6th, 2012)). |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, zirconium and zirconium compounds were classified as respiratory organs sensitizing substance in DFGOT vol. 12 (1999). However, this substance was classified as "Classification not possible" since information on this substance itself could not be obtained. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that sensitization was not seen by application of this substance in a test with human volunteers (ACGIH (2001), DFGOT Vol.12 (1999)). On the other hand, zirconium and zirconium compounds were classified as sensitizers (Sah) by DFGOT (DFGOT vol. 12 (1999)). However, this substance was classified as "Classification not possible" since information on this substance itself could not be obtained. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, a chromosomal aberration test on mouse bone marrow cells by oral administration was positive (DFGOT Vol.12 (1999), PATTY (6th, 2012)). As for in vitro, a bacterial reverse mutation test was negative, and a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells were positive (DFGOT Vol.12 (1999), HSDB (Access on September 2015)). Besides, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government because the positive finding adopted in the previous classification is questionable. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | As classification results by other organizations, ACGIH classified zirconium and zirconium compounds in A4 (ACGIH (7th, 2001)). This substance was classified as "Classification not possible" for this hazard class since it also corresponds to this group of substances. Besides, please refer to this hazard class for zirconium (CAS RN 7440-67-7). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, liver, haemal system), Category 3 (respiratory tract irritation) |
  Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
There are reports that respiratory tract irritation occurs in the process of hydrolysis of this substance to hydrochloric acid (PATTY (6th, 2012), HSDB (Access on September 2015)), and that this substance causes respiratory tract irritation (ACGIH (7th, 2001)). In addition, there is a report that acute intoxication symptoms caused by oral ingestion in humans were a burning sensation in the mouth and throat, vomiting, watery or bloody diarrhea, tenesmus (convulsions), nausea, hemolysis, hematuria, anuria, liver damage with jaundice, convulsions, and hypotension (PATTY (6th, 2012)). There are no data on experimental animals. From the above, in addition to respiratory tract irritation, this substance is thought to affect the nervous system, liver, and haemal system. Therefore, this substance was classified in Category 1 (nervous system, liver, haemal system), Category 3 (respiratory tract irritation). Since the effects on the gastrointestinal system, urinary system, and circulatory organ system adopted in the previous classification were not observed, they were not adopted. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 96-hour LC50 = 15000 microg Zr/L for fish (Lepomis macrochirus) (AQUIRE, 2016), it was classified in Category 3. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. Because it is the metal compound and its behavior in water and bioaccumulation are unknown, and due to acute toxicity Category 3, it was classified in Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |