GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 7782-41-4 |
| Chemical Name | Fluorine |
| Substance ID | H29-B-097 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not classified |
- |
- | - | It is not combustible (ICSC (J) (2001)). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Category 1 |
 Danger |
H270 |
P370+P376
P220 P244 P403 |
This substance is oxidizing gases described in ISO 10156-2017. Compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1045). |
| 5 | Gases under pressure | Compressed gas |
 Warning |
H280 | P410+P403 | From a boiling point of -188.13 deg C and a critical temperature of -129 deg C (HSDB (Access on August 2017)), it was classified as compressed gas. Compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1045). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 1 | Acute toxicity (Inhalation: Gases) | Category 1 |
 Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on 185 ppm (converted 4-hour equivalent value: 92.5 ppm) (ATSDR (2003), PATTY (6th, 2012)) as the LC50 value for rats in a 1-hour inhalation exposure test, this substance was classified in Category 1. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There are descriptions that this substance is a severe skin irritant (ACGIH (7th, 2001), ATSDR (2003)), and that skin irritation in humans was observed at the concentration of 95-100 ppm (150-300 mg/m3) (PATTY (6th, 2012)). In addition, in a skin irritation test with rabbits, when the shaved backs were exposed to the gas of this substance for 0.2 seconds, an ischemic part about 1/4 inch in diameter, surrounded by an erythematous area was produced. There is a description that the ischemic part became eschar of the skin surface accompanied with skin fallout within 4 days, but it healed back to normal epidermis (ATSDR (2003)). Therefore, this substance was classified in Category 2. Besides, this substance was classified as "Skin Corr. 1A" in EU CLP classification (ECHA CL Inventory (Access on July 2017)). The classification was changed based on the information obtained in this research. |
| 3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
For human eyes, there is a description that this substance was very irritating at concentrations of 67-100 ppm. There is a description that marked irritation was shown at 100 ppm (155 mg/m3) of this substance (PATTY (6th, 2012)). There is a description that this substance shows severe eye irritation (ACGIH (7th, 2001)). Therefore, this substance was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in the Food Safety Commission of Japan, as for the mutagenicity of fluorine, in an in-vitro mammalian cell test, a weak positive result was obtained, but in an in-vivo DNA damage test, it was judged that this substance was negative in a comprehensive manner, and it is considered that there is no genotoxicity which is a particular problem for living organisms (Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it was reported that as a result of inhalation exposure of this substance with rats at 18 ppm for 5 weeks, degeneration of the testes was observed, and it was classified in Category 2 based on this in the previous classification. However, since this information was judged to be used for classification of specific target organ toxicity (repeated exposure), it was not adopted. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, liver, kidney) |
 Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
In humans, it is reported that fever, coughing, chest tightness, rales, and cyanosis may develop after inhalation exposure to this substance at high levels, and it is described that these symptoms are indicative of developing delayed pulmonary oedema (EHC 36 (1984)). As for experimental animals, there is a report that in single inhalation exposure tests for 5-60 minutes with rats and mice, diffuse lung congestion, dyspnea, irritation, and alveolar necrosis were observed. There is a report that in single inhalation exposure tests for 5-60 minutes with mice, coagulation necrosis, periportal hemorrhages, and diffuse cloudy swelling in the liver, and focal coagulation necrosis in the renal cortex, focal lymphocyte infiltration in the cortex and medulla in the kidney were observed (above ATSDR (2003)). Effects on these experimental animals were observed at around 50-116 ppm (converted 4-hour equivalent value: 25-58 ppm), which is not higher than the LC50 value and is the dose equivalent to Category 1. Therefore, this substance was classified in Category 1 (respiratory organs, liver, kidney). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (bone, teeth, respiratory organs, genetic organs (men)) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In humans, there is no information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluorides (ACGIH (7th, 2001)). In addition, for fluorides, both beneficial and detrimental dental and skeletal effects have been observed in humans. Fluoride has been shown to decrease the prevalence of dental caries and, under certain conditions, has been used for the treatment of osteoporosis. However, it is described that excess fluoride can also result in dental fluorosis and can result in an increased prevalence of bone fractures in the elderly or patients with skeletal fluorosis (ATSDR (2003)). As for experimental animals, in 5-week inhalation toxicity tests with rats, rabbits, and dogs, no effects in rats, mild bronchial inflammation in rabbits, pulmonary hemorrhage and edema in dogs were observed at or above 2 ppm (converted guidance value: 0.7 ppm), which is within the guidance value of Category 1, and severe pulmonary irritation and testicular degeneration in rats, and hemorrhage in the lungs in rabbits were observed at 18 ppm (converted guidance value: 6 ppm) (ATSDR (2003)). From the above, this substance was classified in Category 1 (bone, teeth, respiratory organs, genetic organs (men)). Besides, the classification result differs from the previous classification because the influence of fluorides to humans was adopted as evidence for classification. |
| 10 | Aspiration hazard | Not applicable |
- |
- | - | Gas (GHS definition) |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |