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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	29082-74-4
Chemical Name	Octachlorostyrene
Substance ID	R01-A-024
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	No data available.
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	No data available.
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >3,710 mg/kg (HSDB (Access on September 2019), Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In a long-term toxicity test with rats for 12 months, no significant increase in incidences of tumors by this substance was observed (Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019)).
7	Reproductive toxicity	-	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	*	- -	-	-	[Rationale for the Classification] There was no report of a single exposure test of this substance in humans. There is a report of (1) with experimental animals. However, this information was judged as insufficient to specify target organs and was not adopted as evidence for the classification. Since no other information was found, it was classified as "Classification not possible." [Reference Data, etc.] (1) In a single dose test of this substance with male rats by gavage at 1300, 1690, 2190, 2850, or 3710 mg/kg, increases in liver weight, hepatic microsomal aniline hydroxylase and aminopyrine demethylase activities, serum cholesterol, and uric acid levels were observed at or above 1,690 mg/kg (corresponding to Category 2). Also, mild histological changes were observed in the thyroid. In addition, hypolocomotion and tremors were observed at or above 2,850 mg/kg (exceeding the range of Category 2). However, no fatal cases were observed in the group of 3,710 mg/kg (HSDB (Access on September 2019), Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, thyroid)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1)-(3), in an oral administration toxicity test with rats, effects on the liver, kidneys and thyroid were observed at doses within the range for Category 1. Therefore, it was classified in Category 1 (liver, kidney, thyroid). [Evidence Data] (1) In a 28-day administration test with rats by feeding at 0.5-500 ppm, enlarged hepatocytes and hepatocyte anisokaryosis, etc. were observed at or above 0.5 ppm (0.043 mg/kg/day (converted guidance value: 0.01 mg/kg/day, within the range of Category 1)) in females, and at or above 5 ppm (0.37 mg/kg/day (converted guidance value: 0.1 mg/kg/day, within the range for Category 1)) in males (Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019)). (2) In a 90-day administration test with rats at 0.5-500 ppm, decreased erythroid cells in males at or above 0.05 ppm (0.0036 mg/kg/day (converted guidance value: 0.001 mg/kg/day, within the range of Category 1)), anemia caused by decreased erythrocyte numbers and amounts of hemoglobin in males, and increased ratio of myeloid cell numbers/erythroid cell numbers (M/E) and delayed maturity of erythroid cells in females at or above 50 ppm (4 mg/kg/day, within the range of Category 1) were observed (Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019)). (3) In a 12-month administration test with rats by feeding at 0.005-50 ppm (male: 0.0003-3.1 mg/kg/day; female: 0.0004-4.4 mg/kg/day, within the range for Category 1), slight anisokaryosis, vacuolar degeneration and ground glass appearance cytoplasm in the hepatocytes, slight follicular atrophy, decreased colloid stainability, and high-columnar-shaped follicular epithelium in the thyroid, and diffuse glomerular adhesions and thickening of basement membrane in the kidney at 0.5 ppm (within the range of Category 1), moderate to severe vacuolar degeneration in the hepatocytes, vacuolar degeneration and papillary proliferation in the thyroid follicular epithelium, proximal tubule dilation, and degeneration with accumulation of eosinophilic bodies and granular casts in the renal epithelium at or above 5.0 ppm (within the range of Category 1), and vacuolar degeneration and papillary proliferation, etc. in the thyroid follicular epithelium at 50 ppm (within the range of Category 1) were observed (Hazard Assessment Report of Endocrine Disruptive Effects by Ministry of Economy, Trade and Industry of Japan (Access on September 2019)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.0058 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 2000)).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, it was classified in Category 1 due to being not rapidly degradable (BIOWIN), and 21-day NOEC = 0.00091 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 2000)).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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