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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	109-61-5
Chemical Name	Propyl chloroformate
Substance ID	R01-B-023
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 26 deg C (closed cup) (ICSC (2005)).
7	Flammable solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 475 deg C (ICSC (2005)).
10	Pyrophoric solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	No data available. Besides, there is information that no metal containers can be used (GESTIS (Access on June 2019)).
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on (1), it was classified in Category 4. [Evidence Data] (1) LD50 for rats: 1,210 mg/kg (SIDS (2012)) [Reference Data, etc.] (2) LD50 for mice: 650 mg/kg (PATTY (6th, 2012))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was not possible to specify the category. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) LD50 for mice: >10 mg/kg (PATTY (6th, 2012))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (26,318 ppm), a reference value in units of ppm was applied as a vapor with little mist. [Evidence Data] (1) When rats were exposed to this substance at 1.019 mg/L (200 ppm) for 1 hour (converted 4-hour equivalent value: 0.51 mg/L (100 ppm), corresponding to the upper limit of Category 1) for 1 hour, 3/10 animals died (SIDS (2012)). Therefore, it was judged that the LC50 value was within the range of Category 2. [Reference Data, etc.] (2) LD50 (1 hour) for mice: 319 ppm (converted 4-hour equivalent value: 159.5 ppm) (PATTY (6th, 2012))
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1B	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1B. [Evidence Data] (1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS (2012), REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) In a skin irritation test in which 0.5 mL of this substance was applied to rabbits under occlusive application for 24 hours, the mean scores of intact skins were 7.8 at 24 hours and 8.0 at 72 hours, and the mean scores of abraded skins were 8.0 both at 24 hours and 72 hours (SIDS Dossier (2012)). (3) It was classified as "Skin Corr. 1B (H314)" in the EU CLP classification (EU CLP classification (Access on July 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1)-(5), it was classified in Category 1. [Evidence Data] (1) In an eye irritation test with rabbits similar to OECD TG 405 (dosage: 0.05 mL), it was corrosive. The mean scores at 24/48/72 hours were 3 for corneal opacity, 2 for iris, 1.8 for conjunctival redness and 2 for chemosis (SIDS (2012), SIDS Dossier (2012), REACH registration dossier (Access on July 2019)). (2) In an eye irritation test with rabbits by the Draize method, it was judged to be an extremely irritant. The symptoms were not reversible within 14 days (SIDS Dossier (2012)). (3) Direct contact with the rabbit eye causes permanent corneal opacity (PATTY (6th, 2012)). (4) It was classified in "Skin Corrosion (Category 1B)."
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Though there is a description in (1), classification was not possible due to lack of data. [Reference Data, etc.] (1) Skin sensitization may occur (PATTY (6th, 2012)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, a negative result was reported in a bacterial reverse mutation test (SIDS (2012)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on information on mucous irritation in humans in (1) and information that effects on the respiratory organs were observed at concentrations within the range of Category 1 in an inhalation exposure test with rats, it was classified in Category 1 (respiratory organs). The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) As general information on humans, there is a description that the vapor of this substance was strongly irritating to the eyes and mucous membranes (PATTY (6th, 2012), HSDB (Access on June 2019)). (2) In a single inhalation exposure test with rats for 1 hour, by an exposure to a vapor of this substance at 1.019 mg/L (converted 4-hour equivalent value: 0.5095 mg/L, within the range of Category 1), dyspnea and mucosal irritation were observed, and 3 of 10 animals died within 6 days after the exposure. Acute pulmonary emphysema was observed at necropsy in rats exposed to 1.385 mg/L (SIDS (2012), SIDS Dossier (2012)). [Reference Data, etc.] (3) In a single oral dose test with rats, dyspnea, apathy, staggering and piloerection were observed in groups dosed at 681 mg/kg and 1,000 mg/kg, and 1 in 10 animals died in each group. Nine in 10 animals died in a group dosed at 1,470 mg/kg, and all animals died in groups dosed at 2,150 mg/kg and 3,160 mg/kg. At necropsy of the dead animals, necrotic white mucosa was observed in the stomach and intestine (SIDS (2012), SIDS Dossier (2012)).
9	Specific target organ toxicity - Repeated exposure	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour LC50 = 3.16 mg/L for fish (Danio rerio) (SIDS, 2012).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (BIOWIN), and it was classified in Category 2 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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