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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	10025-78-2
Chemical Name	Trichlorosilane
Substance ID	R01-B-030
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	It was classified in Category 1 based on a flash point of -25 deg C (closed cup) and a boiling point of 32 deg C (Hommel (1991)).
7	Flammable solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 182 deg C (HSDB (Access on July 2019)).
10	Pyrophoric solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Category 1	Danger	H260	P302+P335+P334 P231+P232 P370+P378 P402+P404 P223 P280 P501	The substance is a compound containing a metalloid (Si), and it is classified in Division 4.3, Subsidiary Risk 3 and 8, PG I in UNRTDG (UN1295). Therefore, it was classified in Category 1.
13	Oxidizing liquids	*	- -	-	-	It is an inorganic compound containing halogen (Cl), but the classification is not possible due to no data.
14	Oxidizing solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Inorganic compound. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to low-temperature-boiling liquids are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on (1), it was classified in Category 4. [Evidence Data] (1) LD50 for rats: 1,030 mg/kg (SIDS (2013), HSDB (Access on July 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. Besides, the exposure concentration was lower than 90% of the saturated vapor concentration (781,114.3 ppm), so the reference values in units of ppm were applied as a vapor with little mist. In addition, since RTECS as evidence of the classification in the previous classification is the information source in List 3 and the data are the findings for mice, they were not used this time, the classification result was changed. [Evidence Data] (1) LC50 (1 hour) for rats: 2,767 ppm (converted 4-hour equivalent value: 1,383.5 ppm) (HSDB (Access on July 2019))
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, the effect was considered to be due to the corrosivity of the hydrolysis product of this substance, hydrochloric acid (CAS RN 7647-01-0). [Evidence Data] (1) Exposure to liquids of this substance causes severe burns to the skin and eyes in humans (HSDB (Access on July 2019)). [Reference Data, etc.] (2) It was classified as "Skin Corr. 1B (H314)" in the EU-CLP classification (EU CLP classification (Access on May 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) Exposure to liquids of this substance causes severe burns to the skin and eyes in humans (HSDB (Access on July 2019)). (2) This substance was classified as Skin corrosion (Category 1).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no in vivo data, and classification is not possible due to lack of data. [Reference Data, etc.] (1) There are no in vivo data for this substance. (2) As for in vitro, it was negative in a bacterial reverse mutation test (SIAP (2013)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) This substance was described as a strong irritant to the respiratory system (HSDB (Access on July 2019)). (2) Since chlorosilanes, including this substance, rapidly hydrolyze on contact with moisture to generate hydrochloric acid (CAS RN 7647-01-0), the toxic effects of this substance are expected to be respiratory and ocular effects resulting from exposure to hydrochloric acid which is produced in vivo. Hydrochloric acid is corrosive and irritating to the skin, eyes and respiratory tract (SIAP (2013)). (3) In rats and mice, inhalation exposure to hydrochloric acid aerosol resulted in death from respiratory failure due to alveolar emphysema, atelectasis and edema of the lungs at concentrations near Category 1 (SIDS (2005)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), effects by the hydrolysis products hydrochloric acid (CAS RN 7647-01-0) and silanetriol (CAS RN 2445-53-6) are considered to occur from exposure to this substance. Also, based on (2) and (3), in humans and experimental animals, effects on the respiratory organs, etc. which are thought to be caused due to the corrosive or irritating properties of hydrochloric acid were observed. Therefore, it was classified in Category 1 (respiratory organs). New information was added and reviewed, and the classification results were changed from the previous classification. [Evidence Data] (1) Chlorosilanes including this substance are expected to rapidly react with moisture producing hydrochloric acid and silanetriol (SIAP (2013)). (2) Inhalation causes severe irritation to the respiratory organs (HSDB (Access on July 2019)). (3) As a result of inhalation exposure to this substance with rats for 9 days (6 hours/day, 5 days/week), respiratory tract irritation, decreased body weight and increased lung weight were observed at 25 ppm (converted guidance value: 0.014 mg/L, within the range of Category 1), interstitial pneumonia and alveolar histiocytosis were observed at 50 ppm (converted guidance value: 0.028 mg/L, within the range of Category 1), and 75% of the animals died at 100 ppm (converted guidance value: 0.055 mg/L, within the range of Category 1) (HSDB (Access on July 2019)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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