NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	144-49-0
Chemical Name	Fluoroacetic acid
Substance ID	R01-B-090
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2017)).
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2017)).
11	Self-heating substances and mixtures	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2017)).
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	The substance is an organic compound containing fluorine and oxygen (but not chlorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 1	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) LD50 for rats: 4.68 mg/kg (HSDB (Access on September 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) Following contact with the skin, burning sensation, reddening, severe irritation, and painful tissue damage may occur. The extent of these symptoms is assumed to be dependent on the concentration and duration of exposure (GESTIS (Access on September 2019)). (2) This substance is irritating (HSDB (Access on September 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) This substance is irritating (HSDB (Access on September 2019)). (2) Following eye contact with the pure grade substance or concentrated solutions, tissue damage and corneal opacity as well as a serious burning sensation and blurred vision should be expected as a consequence of the corrosive action (GESTIS (Access on September 2019)). (3) This substance was classified in Category 1 (skin corrosion).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) It was reported to cause morphological changes in the testes when rats were given sodium fluoroacetate (CAS RN 62-74-8) by drinking water for 21 days (ACGIH (7th, 2001)).
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, cardiovascular system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system, cardiovascular system, respiratory organs). Although the kidney was also adopted as a target organ in the previous classification, it was not adopted since the information was from documents in List 3. The category was changed from the previous classification by the use of new information sources. [Evidence Data] (1) Multiple cases of poisoning were reported in humans by oral ingestion of this substance and sodium fluoroacetate, a sodium salt of this substance (CAS RN 62-74-8). As symptoms, there is a description that convulsive seizures, perspiration, and further increases in blood pressure and heart rate occurred following nausea, epigastric pain, and psychiatric symptoms suggestive of auditory hallucinations, etc., resulting in comatose state. Based on these symptoms, the central nervous system and cardiovascular system were considered as the main target organs (ACGIH (7th, 2001)). (2) It was described that in addition to the above symptoms, arrhythmia and ventricular fibrillation appeared in humans by oral ingestion of this substance (GESTIS (Access on September 2019)). (3) It was described that inhalation of aerosols of this substance, even at low concentrations, may cause severe lung damage and neurological or acidosis-related functional disturbances to the respiratory tract due to the development of pulmonary edema and resulting pneumonia (GESTIS (Access on September 2019)). [Reference Data, etc.] (4) The oral lethal doses of this substance in humans were estimated to be within the range of 2-10 mg/kg (HSDB (Access on September 2019)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, reproductive organs (male))	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Although there were no data on this substance itself, it was classified based on information on sodium fluoroacetate (CAS RN 62-74-8). Based on (1), it was classified in Category 1 (kidney, reproductive organs (men)). [Evidence Data] (1) In a study in which sodium fluoroacetate was administered by drinking water to rats for 21 days, at or above 6.6 ppm (a converted value equivalent to this substance: 0.83 mg/kg/day (converted guidance value: 0.19 mg/kg/day, within the range of Category 1)), effects on the testes (sperm morphology, sperm cells) and degeneration of the renal tubules were observed (ACGIH (7th, 2001)). [Reference Data, etc.] (2) There was a report that a rabbit exterminator in New Zealand who was exposed during preparation of the bait with fluoroacetic acid over a period of 10 years (details unknown) developed severe and progressive lesions of the renal tubular epithelium and milder hepatic, neurologic and thyroid dysfunctions developed (ACGIH (7th, 2001)). (3) There are reports that in subacute and subchronic tests with rats using sodium fluoroacetate, effects on the testes (degeneration of the seminiferous tubules, hypospermia) and heart were observed at 0.25 mg/kg/day (details unknown) (GESTIS (Access on September 2019)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour ErC50 = 0.0042 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2016)).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 because it is rapidly degradable (BIOWIN), and due to 72-hour NOEC = 0.00024 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2016)).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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