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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	1320-37-2
Chemical Name	Dichlorotetrafluoroethane (isomer mixture)
Substance ID	R01-B-112
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	This substance is an isomer mixture consisting of 1,1-dichlorotetrafluoroethane (CAS RN 374-07-2) and 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2). It was classified as "Not classified (Not applicable)" from information of not combustible (1,2-dichlorotetrafluoroethane, ICSC (1998)) and non-flammable (1,1-dichlorotetrafluoroethane, HSDB (Access on December 2019)).
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	No data available.
5	Gases under pressure	Low pressure liquefied gas	Warning	-	-	This substance is an isomer mixture consisting of 1,1-dichlorotetrafluoroethane (CAS RN 374-07-2) and 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2), and 1,1-dichlorotetrafluoroethane has a boiling point of 3.4 deg C and a critical temperature of 145.6 deg C (HSDB (Access on December 2019)), while 1,2-dichlorotetrafluoroethane has a boiling point of 4.1 deg C and a critical temperature of 145.7 deg C (Merck (15th, 2013)). Therefore, it was classified as low-pressure liquefied gas. Besides, 1,1-dichlorotetrafluoroethane is classified in Division 2.2 in UNRTDG (UN3163, liquefied gas, n.o.s.), and 1,2-dichlorotetrafluoroethane is classified in Division 2.2 in UNRTDG (UN1958).
6	Flammable liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to gas substances are not available.
17	Desensitized explosives	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) Based on LC50 values of 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2) for rats: 700,000, 720,000, 750,000 ppm (PATTY (5th, 2002)), it was classified as "Not classified" (FY 2006, GHS classification result).
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
2	Skin corrosion/irritation	*	- -	-	-	[Rationale for the Classification] Although there is data in (2), it was classified as "Not classified" because it is a gas at normal temperature. [Evidence Data] (1) Gas (GHS definition). [Reference Data, etc.] (2) Direct contact with the liquid can trigger irritations to the eyes or skin, followed by frostbite (GESTIS (Access on October 2019)).
3	Serious eye damage/eye irritation	*	- -	-	-	[Rationale for the Classification] Although there is data in (2), it was classified as "Not classified" because it is a gas at nomal temperature. [Evidence Data] (1) Gas (GHS definition). [Reference Data, etc.] (2) Direct contact with the liquid can trigger irritations to the eyes or skin, followed by frostbite (GESTIS (Access on October 2019)). (3) The concentrated gas of this substance can induce irritation to the eyes (GESTIS (Access on October 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2), there is no test result for in vivo. As for in vitro, there are negative results reported in bacterial reverse mutation tests (TA15351 strain) (ACGIH (7th, 2001), EHC 113 (1990)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2) was classified in A4 by ACGIH (ACGIH (7th, 2001)).
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system), Category 3 (narcotic effects, respiratory tract irritation)	Danger Warning	H370 H336 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (cardiovascular system), Category 3 (narcotic effects, respiratory tract irritation). The classification result was changed from the previous classification due to the use of new information sources. [Evidence Data] (1) In a test on 10 subjects, by inhalation exposure of 2,300-21,000 ppm for 15-60 seconds, a significant reduction of the ventilatory lung capacity and cardiac disfunction such as bradycardia and changes in heart rate were observed, with one subject of atrioventricular block (EHC 113 (1990), GESTIS (Access on October 2019)). (2) In an inhalation exposure test with experimental animals, slight respiratory tract irritation was observed at about 10,000 ppm (Category 2), and narcotic effects were observed at or above 100,000 ppm (exceeding Category 2) (GESTIS (Access on October 2019)). [Reference Data, etc.] (3) This substance is a mixture of 1,2-dichlorotetrafluoroethane (CAS RN 76-14-2) and 1,1-dichlorotetrafluoroethane (CAS RN 374-07-2). In EHC 113 (1990), it is described that 1,1-dichlorotetrafluoroethane was usually contained at no more than 7-10%.
9	Specific target organ toxicity - Repeated exposure	*	- -	-	-	[Rationale for the Classification] Based on (1), since no toxic effects were observed in an inhalation exposure test with experimental animals, it was classified as "Not classified." [Evidence Data] (1) In a toxicity test in which dogs were exposed by inhalation to this substance at 5,000 ppm for 90 days (6 hours/day), no toxic effects were observed. No toxic effects were also observed in rats under similar conditions (GESTIS (Access on October 2019)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Category 1	Warning	H420	P502	This substance is listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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