Item | Information |
---|---|
CAS RN | 212201-70-2 |
Chemical Name | 1-(2,4-Dichlorophenyl)-N-(2,4-difluorophenyl)-N-isopropyl-5-oxo-1,5-dihydro-4H-1,2,4-triazole-4-carboxamide; Ipfencarbazone |
Substance ID | R02-A-044-METI, MOE |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing fluorine, chlorine, and oxygen, which are chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (GLP) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (GLP) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LC50 for rats (4 hours): > 5.9 mg/L (GLP) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In a skin irritation test with rabbits (n = 3) (GLP, semi-occlusive, 4-hour application, 72-hour observation), no erythema/eschar, edema, or other irritation changes were observed (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 6) (GLP, 72-hour observation), irritation changes were observed only in the conjunctiva in the unwashed eye group (3 animals) but were fully reversible within 24 hours (in 3 in the unwashed eye group: corneal opacity score: 0/0/0, iritis score: 0/0/0, conjunctival redness score: 0/0/0, chemosis score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] A positive rate did not reach 30% in (1), and it was classified as "Not classified." [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 20) (GLP, intradermal administration: 2.5% suspension), a positive rate was 25% (5/20), 15% (3/20) at 24, 48 hours after a challenge (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using the bone marrow cells of mice (GLP, oral administrations), negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (2) In a comet assay of the urinary bladder of rats (oral administration, 2 days), negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (3) In a bacterial reverse mutation test (GLP), negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (4) In a mammalian cell chromosome aberration test (GLP), negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). [Reference Data, etc.] (5) Based on the test results, a mutagenic potential was not found in this substance (J. Pestic. Sci., 41(3), 111-119 (2016)). |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1B. It was negative in the test with mice, but the incidence of tumors of the urinary bladder was observed at a high frequency with rats. [Evidence Data] (1) In a 2-year carcinogenicity study with rats (GLP, dosed by feeding), in male/female groups at the maximum dose, a significant increase in the incidence frequency of transitional cell papilloma (28/50 (male), 16/50 (female)) and transitional cell carcinoma (26/50 (male), 39/50 (female)) of the urinary bladder were observed. Meanwhile, interstitial cell tumors, which were observed in the testis at or above the mid-dose, were commonly occurring tumors for the strain of rats used, and based on the background data of the testing laboratory, it was considered to be an accidental change due to a low incidence frequency in the control group (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) In an 18-month carcinogenicity study with mice (GLP, dosed by feeding), no increase in the incidence frequency of neoplastic lesions associated with the administration was observed. The carcinogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding (GLP), at 30 ppm, an increase in extramedullary hematopoiesis of the spleen (P and F1 male), congestion and brown pigment deposit of the spleen (P female and F1 male/female), increases in absolute and relative weight of the spleen, and an increase in hematopoiesis of the bone marrow (sternum and femur) (F1 female) were observed in parent animals; and an increase in extramedullary hematopoiesis of the spleen (F1 male) was observed in offspring, but no effect on reproductive ability was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) It was reported that in a developmental toxicity study with rats dosed by gavage (GLP, days 6 to 19 of gestation), at 300 mg/kg/day, weight gain inhibition, a decrease in food consumption, and an enlargement and darkening of the spleen were observed in parent animals; and an increase in the number of fetuses with skeletal variations was observed in offspring, but since there was no significant difference in the incidence frequency per dam, it was not considered to be treatment-related effect. It was reported that teratogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (3) It was reported that in a developmental toxicity study with rabbits dosed by gavage (GLP, days 6 to 27 of gestation), at 15 mg/kg/day, a decrease in food consumption, weight gain inhibition, and darkening of the spleen were observed in parent animals; and low body weight was observed in offspring, but teratogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
8 | Specific target organ toxicity - Single exposure | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (4), in any of the oral, dermal, and inhalation routes, no specific target organ toxicity was observed within the dose range for Category 1 or Category 2, and it was classified as "Not classified." [Evidence Data] (1) It was reported that in an acute oral toxicity test with rats (GLP), at 2,000 mg/kg (within the range for Category 2), there was no death, and loose stool and soiled fur around the anus were observed in males (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (2) It was reported that in an acute oral toxicity test with mice (GLP), at 2,000 mg/kg (within the range for Category 2), enlargements of the liver and the spleen were observed in 1/6 cases (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (3) It was reported that in an acute dermal toxicity test with rats (GLP), at 2,000 mg/kg (within the range for Category 2), neither death nor appearance of symptoms was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (4) It was reported that in an acute inhalation (dust) exposure test with rats (GLP, 4 hours), at 5.9 mg/L (in the range corresponding to "Not classified"), neither death nor appearance of symptoms was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, (2012)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, liver, urinary bladder) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (5), it was classified in Category 1 (blood system, liver, urinary bladder). The kidney was excluded because only pigment deposit and the progress of chronic nephrosis due to aging were observed. [Evidence Data] (1) It was reported that in a 90-day oral toxicity test with rats dosed by feeding, at 10 to 100 ppm (0.592 to 5.97 mg/kg/day (male), 0.664 to 6.69 mg/kg/day (female), within the range for Category 1), effects on the blood (decreases in red blood cell count (RBC)/Hb/Ht, an increase in reticulocytes, leukocyte count and platelet count, an increase in methemoglobin, etc.) were observed, and an increase in hematopoiesis of the bone marrow and findings of the spleen (congestion, hemosiderin deposit, an increase in extramedullary hematopoiesis), which were considered to be associated with the above effects on the blood, and slight effects on the liver (centrilobular hypertrophy of the hepatocytes) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (2) It was reported that in a 90-day oral toxicity test with dogs dosed by feeding, at 30 to 300 ppm (0.792 to 7.79 mg/kg/day (male), 0.789 to 8.09 mg/kg/day, within the range for Category 1), in addition to the effects on the blood, which were the same as in the test in (1) (additional findings: APTT shortening, Heinz body), effects on the liver (additional: centrilobular acidophilic change of the hepatocytes, hemosiderin deposit of the Kupffer cells and lipofuscin deposit of the hepatocytes, increases in ALP/ALT/GGT (mainly in males), etc.) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (3) It was reported that in a 1-year chronic toxicity study with rats dosed by feeding, at 30 to 100 ppm (1.29 to 4.4 mg/kg/day (male), 1.61 to 5.59 mg/kg/day (female), within the range for Category 1), in addition to the effects on the blood, which were the same as in the test in (1) (additional: APTT/PT extension), the findings of the liver (increases in absolute and relative weight, centrilobular hypertrophy/fatty changes of the hepatocytes (female only), altered hepatocellular foci (acidophilic cells/basophilic cells), etc.), the kidney (increases in absolute/relative weight, lipofuscin deposit of the proximal tubules), the urinary bladder (single cell necrosis/apoptosis of mucosa epithelial cells and mucosa epithelium hyperplasia), etc. were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (4) It was reported that in a 2-year carcinogenicity study with rats dosed by feeding, at 30 to 200 ppm (1.09 to 7.44 mg/kg/day (male), 1.4 to 9.67 mg/kg/day (female), within the range for Category 1), as non-neoplastic lesions, effects on the blood, liver, kidney (additional: an increase in the frequency of chronic nephrosis), urinary bladder, etc., which were the same as in the test in (3), were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (5) It was reported that in a 1-year chronic toxicity study with dogs dosed by feeding, at 30 to 100 ppm (0.819 to 2.72 mg/kg/day (male), 0.818 to 2.55 mg/kg/day (female), within the range for Category 1), the findings of the blood and liver, which were the same in the tests in (1) to (3), were observed, and in addition, a weight increase and hypertrophy of the follicular cells in the thyroid were observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). [Reference Data, etc.] (6) It was reported that in an 18-month carcinogenicity study with mice dosed by feeding, at 100 ppm (11.6 mg/kg/day (male), 10.7 mg/kg/day (female), within the range for Category 2), the findings, which were the same as in the carcinogenicity study with rats in (4), were observed in the liver, spleen, bone marrow, and urinary bladder (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.022 mg/L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
It was classified in Category 1 because it is not rapidly degradable (BIOWIN) and due to 72-hour NOErC = 0.00877 mg/L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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