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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	62850-32-2
Chemical Name	S-4-phenoxybutyl N,N-dimethylthiocarbamate; Fenothiocarb
Substance ID	R02-B-117-MHLW
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from information that it is stable to heat at up to 150 deg C (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LD50 for rats: males: 1,150 mg/kg, females: 1,200 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) LD50 for rats: females: 2,080 mg/kg, males: 2,430 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)) (2) LD50 for rats: females: 2,075 mg/kg, males: 2,425 mg/kg (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] The category could not be specified from (1), and it was classified as "Classification not possible." [Evidence Data] (1) LC50 for rats (4 hours): > 1.79 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In a skin irritation test with rabbits, scores were all 0, and it was reported to be negative for irritation (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In an eye irritation test with rabbits, scores were all 0, and it was reported to be negative for irritation (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] There was a description of (1), but because the test methods used were taken as those that were not usable for classification according to the GHS classification guidance for the Japanese government, the classification was not possible. And the classification result was changed because the information source of the rationale data for the previous classification could not be obtained. [Reference Data, etc.] (1) It is reported that in a skin sensitization test with guinea pigs (Draize test), there was a negative result (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)).
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) As for in vivo, it was reported to be positive in a micronucleus test with the bone marrow after gavage administration to mice (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test and positive in the presence of metabolic activation in a chromosomal aberration test with cultured mammalian cells (same as the above). [Reference Data, etc.] (3) It is described that micronucleus induction in the mouse bone marrow could be attributable to hypothermia, and this substance was not carcinogenic (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There were no classification results by domestic and international organizations. There were no available reports in humans. From (1), it was classified as "Not classified." [Evidence Data] (1) In combined chronic toxicity/carcinogenicity tests by 2-year diet administration of this substance to male and female rats and mice, no neoplastic lesions with treatment-related increases in incidence were observed in either species (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1B. In addition, based on new sources of information, the classification results were changed from the previous classification. [Evidence Data] (1) In a two-generation reproduction study with rats dosed by feeding, at a dose at which no parental toxicity was observed, a decrease in implantation rate was observed in F1 females, and at a dose (800 ppm) at which parental toxicity (reduced body weight gain, stricture of the liver due to intimal thickening of the intrahepatic portal branch) was observed, a decrease in implantation rate in P females, a decrease in the number of corpora lutea, and a decrease in the number of implantations in F1 females, a decrease in the number of viable fetuses and an increase in fetal mortality in F2 fetuses, reduced body weight gain and a delay in growth differentiation in F1 and F2 pups, and lower survival rate in F1 pups were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, at a dose (300 mg/kg/day) at which a decrease in locomotor activity, involuntary movement of the head, ataxic gait, salivation, vaginal secretions, and reduced body weight gain were observed in dams, lower body weight, external malformations (encephalocele, rupture of the thoracic wall, rupture of the abdominal wall) and delayed ossification were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). [Reference Data, etc.] (3) In a developmental toxicity study with female rabbits dosed by gavage on days 6 to 18 of gestation, no toxicity effects were observed in either dams or fetuses at the highest dose of 100 mg/kg/day (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	[Rationale for the Classification] There was no report on acute exposure effects of this substance in humans. Based on (1) to (4), it was classified in Category 2 (nervous system). As a result of reviewing the information source, the classification results were changed from the previous classification. [Evidence Data] (1) In an acute oral toxicity test with rats (there was no description of the minimum dose at which effects were observed. It was assumed that effects were observed at least at doses lower than 1,000 mg/kg (within the range for Category 2) at which death began to occur), a decrease in locomotor activity, ataxia, a decrease in respiration rate, blunted response to contact and pain, hypodynamia, prone or lateral position, lacrimation, and dyspnea were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (2) In an acute dermal application test with rats (there was no description of the minimum dose at which effects were observed. It was assumed that effects were observed at least at doses lower than 1,600 mg/kg (within the range for Category 2) at which death began to occur), a decrease in locomotor activity, ataxia, a decrease in respiration rate, blunted response to contact and pain, hypodynamia, prone or lateral position, lacrimation and dyspnea were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (3) In a 4-hour inhalation exposure test with rats (powder, systemic exposure), at or above 1.11 mg/L, a decrease in locomotor activity, eyelid closure, salivation, and irregular breathing were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (4) In a general pharmacological test (oral administration) with mice, decreases in locomotor activity and face rubbing, and decreases in reaction to pain, reaction to contact, strength to grip to a horizontal bar, and abdominal muscle tone were observed at or above 700 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system), Category 2 (blood system, liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	[Rationale for the Classification] There was no report on hazard by repeated exposure to this substance in humans. Based on (1) to (4), effects on the nervous system at doses for Category 1, and blood system and liver at doses for Category 2 were observed in experimental animals. Therefore, it was classified in Category 1 (nervous system), and Category 2 (blood system, liver). With the addition of new information, the classification results were changed from the previous classification. [Evidence Data] (1) It was reported that, in a 90-day feeding test with rats, at or above 300 ppm (males/females: 21.2/22.7 mg/kg/day, both within the range for Category 2), an increase in reticulocyte count was observed in females; at or above 900 ppm (males/females: 63.1/67.7 mg/kg/day, both within the range for Category 2), unkempt fur and a decrease in ALP were observed, and furthermore, intimal thickening of the intrahepatic portal branch, hemorrhage in the medullary cord, and mastocyte infiltration of the mesenteric lymph nodes were observed in males, and an increase in white blood cell count (WBC) and increasesd in absolute and relative liver weight were observed in females; and at 1,200 ppm (males/females: 85.1/87.8 mg/kg/day, both within the range for Category 2), decreases in hemoglobin (Hb) and hematocrit (Ht) and hyperplasia of plasma cells in the medullary cord of the mesenteric lymph nodes were observed, and furthermore, a decrease in red blood cell count (RBC), an increase in reticulocyte count, an increase in ALT, and an increase in extramedullary hematopoiesis in the spleen in males were observed, and increases in platelet count (PLT) and lymphocyte count, intimal thickening of the intrahepatic portal branch, hemorrhage in the medullary cord, and mastocyte infiltration of the mesenteric lymph nodes were observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (2) In a one-year oral toxicity test with dogs dosed by capsules, at 6 mg/kg (within the range for Category 1), tremor, tonic convulsions, salivation, lying on side, quickening of respiration, and gait difficulty were observed, and staggering gait in males and clonic convulsions in females were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (3) It was reported that, in a two-year feeding test with rats, at or above 600 ppm (males/females: 37.3/39.9 mg/kg/day, both within the range for Category 2), intimal thickening of the intrahepatic portal branch, liver atrophy, stomach edema and pigmentation in the small intestine were observed, and furthermore, regenerative renal epithelium was observed in females; and at 1,200 ppm (males/females: 83.7/88.2 mg/kg/day, both within the range for Category 2), decreases in Ht and Hb, necrosis of the liver, and atrophy of the pancreatic exocrine gland were observed, and furthermore, an increase in mortality, a decrease in RBC, and an increase in PLT were observed in males, and fibrosis of the heart was observed in females. Additionally, in a group of rats sacrificed in week 52 of this test, at or above 600 ppm (males/females: 37.3/39.9 mg/kg/day, both within the range for Category 2), intimal thickening of the intrahepatic portal branch was observed, and furthermore, stomach edema and pigmentation in the small intestine were observed in females; and at 1,200 ppm (males/females: 83.7/88.2 mg/kg/day, both within the range for Category 2), a decrease in Ht and liver atrophy were observed, and furthermore, a decrease in RBC, an increase in neutrophil percentage, a decrease in lymphocyte percentage, and pigmentation in the small intestine were observed in males, and a decrease in Hb and increases in PLT and WBC were observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (4) In a 28-day inhalation (dust) toxicity test with rats, at or above 120 mg/m3 (converted value in 90 days, 6 hours/day, 7 days/week: 0.032 mg/L, within the range for Category 2), an increase in nasal discharge and an increase in ALT were observed, and furthermore, a decrease in Ht in males and salivation, an increase in WBC, an increase in AST, and a decrease in ALP in females were observed; and at 360 mg/m3 (0.36 mg/L, exceeding Category 2), death (males: 9 cases, females: all cases), a decrease in locomotor activity, salivation, rough hair coat, myocarditis, thymic atrophy, spleen extramedullary hematopoiesis, hepatic congestion and centrilobular hepatocyte necrosis, granular matters in the renal tubules, pulmonary congestion, edema, and hemorrhage were observed, and in females, a decrease in muscle tone, piloerection, anemia, and urinary incontinence were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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