Item | Information |
---|---|
CAS RN | 513-79-1 |
Chemical Name | Cobalt(II) carbonate |
Substance ID | R03-C-022-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2016 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Although there is no data of this substance itself, based on (1) to (4), it is assumed that this substance, which is insoluble in water, also releases the divalent cobalt ion and causes toxicity similar to that of water-soluble cobalt compounds. Therefore, the classification result of cobalt (II) chloride was applied and it was classified in Category 2. [Evidence Data] (1) The first step in the toxicity process of cobalt compounds is the release of cobalt ions in vivo. Water-soluble cobalt compounds release cobalt ions into biological fluids outside the cell, and the ions enter the cell through ion channels within the cell membrane. In contrast, poorly soluble cobalt compounds are taken up by organelles (lysosomes) in the cell via a process called endocytosis; cobalt is then solubilized in the acidic environment in the organelles, and the ions are released inside the cell. Evidence for cellular uptake of the different forms of cobalt compounds is provided by in vitro study results (NTP RoC 14th (2016), AICIS IMAP (2014), ECHA RAC & SEAC Final Opinion (Background Doc.) (2020)). (2) Based on (1), this substance (insoluble cobalt compound) and other four cobalt compounds (water-soluble compounds) are considered to have similar bioavailability. Assuming that all the cobalt compounds are soluble in biological fluids after inhalation or oral exposure and release the divalent cobalt ion at similar rates, data obtained from one cobalt compound can be read across to other cobalt compounds of which data are not available. That is, it is considered that the data can be mutually applicable among the cobalt compounds that can release the divalent cobalt ion (ECHA RAC & SEAC Final Opinion (Background Doc.) (2020), AICIS IMAP (2014)). (3) Cobalt (II) chloride (CAS RN 7646-79-9) was classified in Category 2 for this hazard class (GHS Classification Result in FY2015). (4) In the EU classification, this substance was classified as Muta. 2 (REACH registration dossier (Accessed Oct. 2021)). |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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