Item | Information |
---|---|
CAS RN | 693-98-1 |
Chemical Name | 2-Methylimidazole |
Substance ID | R03-C-040-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1B. It was classified based on the new information source. [Evidence Data] (1) In a reproduction/developmental toxicity screening test (OECD TG 421, GLP) with rats dosed by gavage, at the highest dose of 500 mg/kg/day, 2/10 dams died during or shortly after parturition, which was considered to be an adverse effect of the administration of this substance on parturition (complicated parturition). In addition, reduced body weight gain, a tendency to an increase in the duration of pregnancy (within the background data), an increase in the number of stillborn pups, and a decrease in the live birth index were observed in dams of the same group. It was reported that, in offspring, a dose-dependent increase in the incidence with aneurysm (aorta, the region of the ductus arteriosus and the pulmonary trunk) was observed from the low dose (50 mg/kg/day), and a decrease in the viability index on postnatal days 0 to 4 was observed in the highest dose group (CLH Report (2016), AICIS IMAP (2016), ECHA RAC Opinion (2017), REACH registration dossier (Accessed Oct. 2021)). (2) It was reported that, in a developmental toxicity study (GLP) with female rats dosed by gavage from day 6 of gestation to postnatal day 3, no effects were observed in dams up to the highest dose of 50 mg/kg/day, but in offspring, an increase in the incidence with dissecting aneurysm of the aorta and intramural hemorrhage was observed from the low dose (2 mg/kg/day) (CLH Report (2016), AICIS IMAP (2016), ECHA RAC Opinion (2017), REACH registration dossier (Accessed Oct. 2021)). (3) Based on (1) and (2), a dose-dependent increase in the incidence of aneurysm was observed from the low dose of 2 mg/kg/day in two tests. A decrease in the viability index was observed in offspring at 500 mg/kg/day. Since the maternal toxicity is limited to body weight changes at 500mg/kg/day, the developmental effects in offspring cannot be considered to be secondary to maternal toxicity. Therefore, it was reported that the classification in Repr. 1B was determined to be appropriate (CLH Report (2016), ECHA RAC Opinion (2017)). [Reference Data, etc.] (4) In the EU CLP, it was classified in Repr. 1B (EU CLP Classification Results (Accessed Oct. 2021)). |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|