NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	100-69-6
Chemical Name	2-Vinylpyridine
Substance ID	m-nite-100-69-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of 42 deg C (ICSC (2000)), it was classified in Category 3. Besides, stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, PG II (UN 3073) in UNRTDG.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, because stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, it is estimated that it does not correspond to self-reactive substances and mixtures which is hazard class with the highest precedence.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	Because stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, it is estimated that it does not correspond to pyrophoric liquids which is hazard class with the highest precedence.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on a report that the LD50 value ranged between >50 and <300 mg/kg (OECD TG 423) for rats (SIDS (2014)), this substance was classified in Category 3.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on the LD50 value of 640 mg/kg (SIDS (2014)) for rabbits, this substance was classified in Category 3. 　The classification was revised based on the new information. 　Besides, in the previous classification, an LD50 value of 160 mg/kg (PATTY (4th, 2000)) for guinea pigs was used as the rationale for classification. However, since an LD50 value for rabbits was obtained, which has a higher priority in the GHS Classification Guidance for the Japanese Government, it was classified using the LD50 value for rabbits.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a report that in a study using rabbits, as a result of the application of 0.5 ml of an undiluted solution of this substance for 1 hour, necrosis was observed (SIDS (2014)). In addition, it is described that this substance caused strong irritation to rabbits (PATTY (6th, 2012)). Moreover, there is a report that this substance caused skin burns after contact with human skin, and the site of inflammation became reddish-brown and took about a month to disappear (Initial Risk Assessment Report (NITE, CERI, NEDO,2005), PATTY (6th, 2012)). From the above, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that in an eye irritation test using rabbits, strong irritation was observed (SIDS (2014), PATTY (6th, 2012)). In addition, there is a report that in an eye irritation test using guinea pigs, strong irritation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). Moreover, this substance is classified in Category 1 for skin corrosion/irritation. From the above, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is reported that exposure to this substance caused sensitization in humans, and there are several descriptions that this substance shows skin sensitization in humans (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). Moreover, it is reported that in a skin sensitization test using guinea pigs, it is positive (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012)). 　From the above, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, in gene mutation tests (reporter gene: gpt and red/gam) using the liver, bone marrow, stomach (glandular stomach) and testes of transgenic mice (gpt delta) administered by oral, this substance is negative (JECDB (Access on October 2016)). 　As for in vitro, the results of bacterial reverse mutation tests were positive and negative, and a mammalian cell chromosome aberration test was positive (JECDB (Access on October 2016), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2014), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). From the above, positive results are observed in vitro, but there was no positive report in in vivo tests. Therefore, this substance was classified as "Classification not possible" according to the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, it is described that in a test in which female mice were intraperitoneally administered with a total of 200 micro mol of this substance over 20 times at a rate of 3 times/week (equivalent to about 9 mg/kg/day), the incidence of lung adenoma/adenocarcinoma was 0/25, 0/23 and 24/24 in the vehicle control group, the group dosed with this substance, and the positive control group, respectively (SIDS (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the reproduction/developmental toxicity screening test (OECD TG 421) using rats given by gavage, abnormal delivery cases including dystocia and stillborn, etc. were observed at 50 mg/kg/day or above. Also, of the twelve female parental animals in each group, at 50 mg/kg/day, two were euthanized; at 125 mg/kg/day, two were euthanized due to dystocia, three died before starting delivery, four died during the nursing period, and three were euthanized. As for male parental animals, an increase in the number of spermatogonia in stages I–VI, a decrease in the number of spermatogonia in stages IX–XI, and decreases in spermatocytes in the leptotene and pachytene or diplotene stage were observed at 125 mg/kg/day. 　As for the pups, all pups from 1 dam died at 50 mg/kg/day during the lactation period and all newborn pups died at 125 mg/kg/day (SIDS (2014), JECDB (Access on September 2016)). 　Besides, in female parental animals at 50 mg/kg/day or above and male parental animals at 125 mg/kg/day, macroscopic findings including mucosal hypertrophy in the forestomach, thymic atrophy and adrenal hypertrophy, and histopathological changes (ulcers, etc. in the forestomach, atrophy of the thymic cortex, hypertrophy of adrenal zona fasciculata cortical cells, etc.) are observed (JECDB (Access on September 2016)). 　From the above, since at the doses where effects on general toxicity were observed, abnormal delivery in the maternal animals and postnatal deaths were observed in the pups, this substance was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for humans, there is a report that in several cases of brief exposure to this substance and 4-vinylpyridine during experiments, eye, nose, and throat irritations; headaches; nausea; nervousness; and anorexia were observed (PATTY (6th, 2012), SIDS (2014), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). 　As for experimental animals, in a single oral dose study using rats, salivation, diarrhoea, vasodilation, reduced food intake, decrease in locomotor activity, muscle weakness and tremors were observed at 336 mg/kg, which is equivalent to Category 2 (SIDS (2014), Hazard Assessment Report (CERI, NITE, 2005). Moreover, there is a report that in a 17-day repeated dose toxicity study using rats administered by gavage, diminished activity, tremors and convulsions were observed at 500 mg/kg/day, which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). It is thought that these symptoms are acute effects because all animals died after 1 - 2 doses. 　From the above, this substance was classified in Category 1 (nervous system) and Category 3 (respiratory tract irritation).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no relevant information on humans. 　As for experimental animals, in a 28-day repeated dose toxicity study, a 92-day repeated dose toxicity study using rats administered by gavage, etc., effects on the stomach due to irritation (hyperplasia of squamous epithelium, submucosal edema, erosion and cellular infiltration in the forestomach, and submucosal edema, erosion, etc. in the glandular stomach) are observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), SIDS (2014)). 　In addition, it is reported that in a 92-day repeated dose toxicity study using rats administered by gavage, convulsions and salivation were observed at 180 mg/kg/day, which is above Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), SIDS (2014), HSDB (Access on October 2016)). 　Moreover, it is reported that in a 17-day repeated dose toxicity study using rats administered by gavage, diminished activity, tremors and convulsions were observed at 500 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). However, it is thought that these are acute effects because all animals died after 1 - 2 doses. 　From the above, within the range of Category 2, there are only effects on the stomach by oral administration due to irritation, so classification is not possible.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, from the numerical data (Viscosity: 1.17 mPa*s (20 deg C), density (specific gravity): 0.9985 (20/0 deg C)) listed in HSDB (Access on September 2016), the kinematic viscosity is calculated to be 1.17 mm2/sec (20 deg C).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50 = 6.48 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)), it was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991), and 21-day NOEC = 0.901 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)). 　If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991), and 96-hour LC50 = 6.48 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)). 　It was classified in Category 2 from the above results.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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