NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10025-87-3
Chemical Name	Phosphoryl chloride
Substance ID	m-nite-10025-87-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (1997)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It reacts violently with water to produce heat and decomposition products including hydrochloric acid and phosphoric acid, generating fire and explosion hazard (ICSC (1997)), but flammable gases are not emitted.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing halogen and oxygen, but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	There are 2 reports of LD50 values of 36 mg/kg and 380 mg/kg for rats (SIDS (2006)). They correspond to Category 2 and Category 4, respectively, however, it was classified in Category 2 to which the smallest value among LD50 values corresponds. A new information source (SIDS (2006)) was added, and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	There are reports of LD50 values of 1,000 mg/kg< LD50 <1,580 mg/kg (male) and 631 mg/kg< LD50 <1,000 mg/kg (female) for rabbits (SIDS (2006)). They correspond to Category 3 and Category 4, respectively, however, it was classified in Category 3 to which the smallest value among LD50 values corresponds. A new information source (SIDS (2006)) was added, and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a report of an LC50 value (4 hours) of 48.4 ppm for rats (SIDS (2006), ACGIH (7th, 2001)), it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (52,320 ppm), the reference value in units of ppm was applied as a vapour without a mist.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There are multiple results that it was corrosive in skin irritation tests with rabbits (SIDS (2006)), and this substance was judged as a corrosive substance in SIDS (2006). In addition, there is a description that it may cause intense irritation also in humans (ACGIH (7th, 2001)). From the above results, it was classified in Category 1. Besides, this substance was classified in "C; R35" in EU DSD classification and in "Skin Corr. 1B H314" in EU CLP classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are multiple reports that severe damages were observed in eye irritation tests with rabbits (SIDS (2006)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports that no sensitization was observed in a maximization test with guinea pigs and a mouse ear swelling test (SIDS (2006)), however, details such as test conditions were unknown, therefore, the data were judged to be insufficient for use in classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests (SIDS (2006)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is severely irritating to the respiratory tract (SIDS (2006), ACGIH (7th, 2001)). In humans, headache, dizziness, nausea, vomiting, chest pain, cough, wheezing, dyspnea, bronchitis, bronchopneumonia and pulmonary edema by the inhalation exposure, and stomach pain, vomiting, perforations of the esophagus and stomach and prostration by the oral exposure were reported (SIDS (2006), PATTY (6th, 2012), ACGIH (7th, 2001), HSDB (Access on September 2014)). As for experimental animals, salivation, lateral position, disturbance of movement co-ordination, labored breathing, convulsions and respiratory impairment by the inhalation exposure of rats, and disturbance of movement co-ordination, weakness and reduced respiratory frequency by the oral administration to rats were reported (SIDS (2006)). Effects by inhalation in rats were observed within the dose range corresponding to Category 1, and effects in rats orally dosed were observed within the dose range corresponding to Category 2. From the above, it was classified in Category 1 (central nervous system, respiratory organs). Besides, degeneration of the nerve cells of rats described in the previous classification was not adopted because it was described as that in a repeated dose study.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, respiratory organs, kidney)	Danger	H372	P260 P264 P270 P314 P501	There are descriptions that chronic inhalation effects by the occupational exposure in humans included the instances of nephritis (ACGIH (7th, 2001), PATTY (6th, 2012)) in addition to effects on the respiratory organs (cough, rhinitis, bronchitis, bronchopneumonia, pulmonary edema, etc.) and effects on the central nervous system (headache, dizziness, sleeping disorders, weakness, nausea, etc.) (SIDS (2006), ACGIH (7th, 2001)). As for experimental animals, there is a description that by the inhalation exposure to this substance (estimated as a vapour) with rats for 4 months, effects on the kidney (increased kidney weight, fatty degeneration) were observed in addition to irritating effects on the respiratory system (rhinitis, bronchitis) at concentrations of 0.48-1.34 mg/m3 (converted guidance value: 0.00032-0.00089 mg/L/6 hours) (SIDS (2006)). From the above, it was classified in Category 1 (central nervous system, respiratory organs, kidney).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 72-hour ErC50 = 32.12 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 12.5 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006) although environmental dynamics of the inorganic compound are unknown. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" from 48-hour EC50 > 100 mg/L for crustacea (Daphnia magna) (a test with pH adjusted solutions, SIDS, 2006) although environmental dynamics of the inorganic compound are unknown. This substance decomposes readily in water to produce hydrochloric acid and phosphoric acid, decreasing pH, and it is concluded that the decreased pH causes the effetcs on aquatic organisms (SIDS, 2006). On top of that, based on the expert judgment, it was classified as "Not classified" in chronic toxicity.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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