NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10025-91-9
Chemical Name	Antimony chloride (Antimony trichloride)
Substance ID	m-nite-10025-91-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water because water solubility was measured. Water solubility: 10g/100mL (25 deg C) (ICSC (2004))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing chlorine (but not oxygen), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on LD50 values of 360 mg Sb/kg bw (673 mg/kg as SbCl3), 280 mg Sb/kg bw (523 mg/kg as SbCl3) and 214 mg Sb/kg bw (400 mg/kg as SbCl3) for rats (DFGOT vol. 23 (2007)), this substances was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a reported of an LD50 value of < 314 mg/kg for guinea pigs (DFGOT vol. 23 (2007)), but it was not possible to identify the category from this value alone.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although no concrete information of animal tests is available, there is a description that this substance is irritating and caustic to the skin (HSDB (Access on August 2015)). Besides, there are 3 reports of patch tests with volunteers as follows: as a result of application of this substance (2%) for 48 hours, 17 volunteers showed no reaction (DFGOT vol. 23 (2007)); as a result of application of this substance (1%) to 95 volunteers, 2 showed erythema and one showed infiltrating erythema (DFGOT vol. 23 (2007)); and, as a result of application of this substance (1%) to 80 volunteers, after 48 hours, 4 showed erythema and one showed infiltrating erythema (DFGOT vol. 23 (2007)). From the above, this substance was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although no concrete information of animal tests is available, there are descriptions that this substance has severe irritating property to eyes and causes deep burns (HSDB (Access on August 2015)). From the above, this substance was classified in Category 2A.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in 3 reports of patch tests with volunteers, it is reported that as a result of applying this substance (1% or 2%) for 48 hours, no allergic reaction was observed (DFGOT vol. 23 (2007)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, it was positive in a chromosomal aberration test with mouse bone marrow cells by oral administration (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and as for in vitro, a bacterial reverse mutation test, a micronucleus assay and a sister chromatid exchange analysis with mammalian cultured cells were positive (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, since there is a positive result from the in vivo somatic cell mutagenicity test, this substance was classified in Category 2 according to the GHS Classification Guidance for the Japanese Government.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	As for antimony compounds other than antimony trioxide, they were not classified for carcinogenicity by either ACGIH (ACGIH (7th, 2001)) or Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits Vol.55 (2013)). Therefore, classification of this substance is not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a description on the following test. In a study where pregnant rats were dosed 1 or 10 mg/L (ca. 0.1 or 1 mg/kg/day) of this substance by drinking water during gestational period and lactation period until 60 days after weaning of the offspring, maternal rats showed dose-dependent weight loss on gestational day 20, but no effect on duration of pregnancy and the number of litter. In the pups of the high concentration group where the rats were continually dosed before and after birth, delay in body weight gain was seen, but no macroscopic malformations (DFGOT vol. 23 (2007), HSDB (Access on August 2015)). Despite of the above description, it is only the surficial abnormality observation, and it is an insufficient report to evaluate teratogenicity. In addition, as a result of administrating 187 mg/kg/day of this substance via intramuscular injection during the organogenesis period (6-15 gestational days) of pregnant rats, fetotoxicity (increase in fetal resorption, decrease in the number of alive fetus, decrease in fetal body weights) was observed, but there is no description of the effect on the maternal animals (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, there is no adequate data for classification and classification was not possible due to lack of data. Besides, in the previous classification, there was a description that effect on the next generation was observed at the dose where general toxicity was observed in maternal animals. And it was considered that antagonism against for the vasopressor reaction in the pups, which occurred by administration of acetylcholine etc. or occlusion of carotid artery, was from the exposure of this substance. However, because exposure to this substance did not change systolic blood pressure in untreated animals, it was not judged to be appropriate as the evidence for classification from the view point of toxicological significance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There is a description that this substance induces respiratory tract irritation, rhinitis, acute pulmonary edema in humans (HSDB (Access on August 2015)) and effects on the respiratory organs were observed. However, because such information was not described in the information source in List 1, this substance was classified in Category 2 (respiratory organs). No data available for experimental animals.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	No information on humans is available. As for experimental animals, in a 6-month oral dose test with guinea pigs, at 2.5 mg/kg/day, which is within the range of Category 1, an increase in globulin fraction in serum proteins, a decrease in total serum proteins, a decrease in haemoglobin level and red blood cell count, an increase in reticulocyte count and a decrease of free SH-groups in serum were observed. (DFGOT vol. 23 (2007)). Therefore, this substance was classified in Category 1 (haemal system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 64-hour EC50 = 19.8 mg Sb/L (converted value: 37 mg SbCl3/L) for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)), it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. Due to the unknown behavior of the inorganic compound in water, and acute toxicity Category 3, it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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