NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10108-64-2
Chemical Name	Cadmium chloride
Substance ID	m-nite-10108-64-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2005))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	The substance is "Not combustible" (ICSC (2005)), and it does not spontaneously ignite on contact with room temperature air.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2005))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is considered to be stable against water since data are available that water solubility is 140 g/100 mL (20 degC) (HSDB (2009)) through it contains metals (Cd).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is inorganic compound containing chlorine.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on LD50 values of 107, 129, 225, 327 mg/kg (PATTY (5th, 2001) and 88 - 302 mg/kg (CaPSAR (1994)) for rats, the substance was classified into Category 3. There is a data of a LD50 value of 29 mg/kg for 2-week old rats (PATTY (5th, 2001).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. As relevant information, there is a report of "causes smarting of the skin and first degree burns on short exposure" for human effects (HSDB (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	Based on a negative result in a guinea pig maximization test (DFGOT vol. 22 (2006)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] As in vivo test results on this substance, there are no positive reports in a dominant lethal test, but results showing chromosomal aberrations in germ cells (2) and results showing somatic cell mutagenicity (3) were obtained. From the above, because there are results indicating germ cell mutagenicity in part of animal tests, it was classified in Category 1B. [Evidence Data] (1) In a dominant lethal test on this substance, there are no results by which it is clearly judged to be positive (ATSDR (2012), IARC 58 (1993), DFGOT Vol. 22 (2006)) (2) It is reported that after administrating this substance, chromosomal aberrations in mouse spermatocytes and hamster oocytes and altered gene expression in mouse spermatid occurred (ATSDR (2012), IARC 58 (1993), DFGOT Vol. 22 (2006)). (3) It is reported that as the result of administrating this substance to mice, dose-dependent increases in the incidences of micronuclei, sister chromatid exchanges, and chromosomal aberrations were observed in the peripheral blood. Moreover, it is reported that increased single strand breaks in the DNA were observed in rats after administrating cadmium chloride (EU-RAR (2007), DFGOT Vol. 22 (2006), NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (4) It is reported that increases in the incidences of micronuclei and sister chromatid exchanges in peripheral lymphocytes were shown in workers occupationally exposed to cadmium (compound not specified) and that human lymphocytes from people inhabiting cadmium-polluted areas of China were found to have increased micronuclei rates and a higher frequency of chromosomal aberrations and severe aberration types. However, conflicting knowledge is also reported (ATSDR (2012)). (5) As for in vitro, positive results are reported in a chromosomal aberration test and a sister chromatid exchange test in mouse spleen cells and a DNA single-strand break assay in Escherichia coli (NICNAS IMAP (Accessed Jan. 2019)). (6) Water solubility of this substance is 1,400 g/L (20 deg C) (ATSDR (2012), EHC 135 (1993), DFGOT Vol. 22 (2006)), and it is very soluble in water. (7) This substance was classified in Muta. 1B in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and as "Category 1" in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, liver, gastrointestinal system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	For the substance there is a report of "liver damage" for humans (ATSDR (2008)). In rats, "pulmonary edema (0.005 mg/L/1h), pneumonitis (0.0065 mg/L/1h), alveolar pneumocyte type 1 cell damage and necrosis (0.006 mg/L/2h)" were noted after inhalation (dust) exposure (ATSDR (2008)) and "focal degeneration and necrosis of parenchymal cells in the liver (75 mg/kg)" were observed after oral administration (ATSDR (2008)). These effects were observed at dose levels within the guidance value range for Category 1. In addition, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting, and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, liver, alimentary system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, bone, liver, kidney, heart)	Danger	H372	P260 P264 P270 P314 P501	For the substance, in inhalation (dust) tests with rats, mice and hamsters, inflammatory and proliferative changes in the lungs were induced at an exposure concentration of 0.4 - 0.5 microg/L/4h (CaPSAR (1994)). In oral tests with rats, changes in calcium metabolism and osteomalacia (1 microg/kg/day for six months) (EHC 61 (1988), ATSDR (2008)), necrosis of central lobules in the liver and necrosis of proximal tubular epithelial cells (8.58 mg/kg/day for 12 weeks), anemia, osteomalacia (3.6 mg/kg/day for 120 days), and congestion and separation of muscle fibers in the heart (2.5 mg/kg/day for 7 weeks) were noted (ATSDR (2008)). Based on the data, target organs were considered to be lung, bone, liver, kidney and heart. The effects on animals were observed at dose levels within the guidance value range for Category 1. The substance was classified into Category 1 (respiratory system, bone, liver, kidney, heart).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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