Item | Information |
---|---|
CAS RN | 105-87-3 |
Chemical Name | Geranyl acetate |
Substance ID | m-nite-105-87-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point was 109.5 deg C (Closed cup) (GESTIS (Accessed Sep. 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (ethylene group) present in the molecule, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 252 deg C (ECHA (Accessed Sep. 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: about 6,330 mg/kg (JECFA (1967), NTP TR252 (1987)) [Reference Data, etc.] (2) LD50 for rats (a mixture of 71% of this substance and 29% of citronellyl acetate): between 4,000-8,000 mg/kg (NTP TR252 (1987), NICNAS IMAP (2017)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) It is reported that in a skin irritation test with rabbits (n = 6) (two open applications, 24-hour application, 72-hour observation), irritation of relative score 3 (severe irritation) was observed (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) It is reported that in a local lymph node assay (LLNA) with mice (n = 5/group) (OECD TG 429, GLP), stimulation index (SI values) was 4.95 (25%), 7.33 (50%), 7.56 (100%) (REACH registration dossier (Accessed Oct. 2020)). [Reference Data, etc.] (2) It is reported that in a maximization test in 25 persons (4% in petrolatum), this substance was not considered sensitizing, but hypersensitivity was observed in certain individuals (AICIS (formerly, NICNAS IMAP) (2017)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (7), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using mouse bone marrow cells (intraperitoneal injection, 3 days), negative results were reported (REACH registration dossier (Accessed Oct. 2020), NICNAS IMAP (2017)). (2) It was reported that in a mouse bone marrow chromosomal aberration test (by single-dose intraperitoneal administration), positive results were obtained, but in a confirmation test which was conducted under the same conditions, the results were negative and no reproducibility was observed (REACH registration dossier (Accessed Sep. 2020)). (3) In a sister chromatid exchange test using mouse bone marrow cells, negative results were obtained, and in a comet assay with the bone marrow, brain, lung, liver, kidney and stomach etc. from mice as the target organs, negative results were obtained (REACH registration dossier (Accessed Sep. 2020)). (4) In a bacterial reverse mutation test, negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (5) It was reported that in a chromosomal aberration test using Chinese hamster ovary cells (CHO), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (6) In a sister chromatid exchange test using CHO, weakly positive (S9-) results were reported (REACH registration dossier (Accessed Oct. 2020)). (7) In unscheduled DNA synthesis tests using rat primary cultured hepatocytes, negative results were reported (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a two-year carcinogenicity study by oral administration of a mixture containing this substance by 71% and citronellyl acetate (CAS RN 150-84-5) by 29% to rats or mice dosed by gavage (5 days/week), no clear evidence of carcinogenic effects was observed in either males or females of rats or mice. However, the survival rate of male rats and male and female mice in the high dose groups and that of female mice in the low dose group decreased, and there was a possibility that the sensitivity for detecting tumors was lowered. It was reported that there was a possibility that the slight increases in renal tubular cell adenomas in male rats in the low dose group and squamous carcinomas of the skin in male rats in the low dose group were associated with the administration of this substance (NTP TR252 (1987)). (2) Although renal tubular cell adenomas in male rats and skin tumors in male mice were observed as described in the NTP test results above, the symptoms did not show a significant increase in the high dose groups and were not dose-related. Therefore, the effects were not considered to be related to the administration. It was concluded that this substance was not considered to have carcinogenicity (REACH registration dossier (Accessed Sep. 2020), NICNAS IMAP (2017)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. [Reference Data, etc.] (1) It was reported that in a reproduction/developmental toxicity screening test with rats by dermal administration of geraniol (CAS RN 106-24-1), which was a hydrolysate of this substance and used as the test substance (OECD TG 421, from 2 weeks before mating until day 3 of lactation), no reproductive toxicity was observed at the doses where no severe dermal irritation was observed (REACH registration dossier (Accessed Sep. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route. The findings in (2) were considered to be nonspecific symptoms that appeared near the lethal dose. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes. [Evidence Data] (1) It was reported that in an acute oral toxicity test with rats and mice dosed by feeding, the animals became inactive immediately after the substance was administered at each dose from 500 to 4000 mg/kg (from the range for Category 2 to the range corresponding to "Not classified") (NTP TR252 (1987), NICNAS IMAP (2017)). (2) It was reported that in an acute oral toxicity test with rats dosed by feeding, depression and coma were observed before death. The LD50 was reported to be 6,330 mg/kg (JECFA (1967), NTP TR252 (1987)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes. [Evidence Data] (1) It was reported that in a 13-week oral administration test with rats dosed by gavage (5 days/week), no effect was observed at doses of up to 2,000 mg/kg/day (converted 7 days/week equivalent value: 1,430 mg/kg/day, in the range corresponding to "Not classified"), but death (2/10 males, 1/10 females), depression, reduced body weight gain, and reddened mucosa of the stomach (males) were observed at 4,000 mg/kg/day (converted 7 days/week equivalent value: 2,860 mg/kg/day, in the range corresponding to "Not classified"). However, no treatment-related abnormality was observed in a histopathological examination (NTP TR 252 (1987), NICNAS IMAP (2017)). (2) It was reported that in a 13-week oral administration test with mice dosed by gavage (5 days/week), no effect was observed at doses of up to 1,000 mg/kg/day (converted 7 days/week equivalent value: 714 mg/kg/day, in the range corresponding to "Not classified"), but death, effects on the liver, kidney, myocardium (cytoplasmic vacuolization, accumulation of lipid in the vacuoles and cells), and stomach effects (focal suppurative inflammation, focal ulcerative inflammation, submucosal edema) were observed at 2,000 mg/kg/day (converted 7 days/week equivalent value: 1,430 mg/kg/day, in the range corresponding to "Not classified") (NTP TR 252 (1987), NICNAS IMAP (2017)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 72-hour ErC50 = 3.72 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2021). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 because sufficient data on rapid degradability were not obtained and due to 72-hour NOErC = 0.585 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2021). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 because sufficient data on rapid degradability were not obtained and due to 48-hour EC50 = 14.1 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). By drawing a comparison between the above results, it was classified in Category 2. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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