NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	106-93-4
Chemical Name	1,2-Dibromoethane (EDB)
Substance ID	m-nite-106-93-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Non-combustible (Hommel, 1991).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Non-combustible (Hommel, 1991)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible (Hommel, 1991)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine and chlorine.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG Class: 6.1, PGI	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Rat LD50 values of 146 mg/kg (male), 117 mg/kg (female), and 140 mg/kg (male and female) (EHC 177 (1996)) corresponded to classification target, and it was set as Category 3 based on the lowest value of 117 mg/kg.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was set as Category 3 based on rabbit LD50= 450mg/kg (EHC 177 (1996)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Rat LC50 value 2.304mg/L and 4.620mg/L (4-hour equivalent of 2.31mg/L) (EHC 177 (1996)) corresponded as subjects of classification. Both were equivalent to about 300ppm, and it was classified as Category 2 with the application of the gaseous classification Category. [saturated vapor pressure concentration: 10^(6) *1.5 / 101(kPa) = 14851ppm]	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although significant irritation accompanied by erythema and edema which progress to necrosis and eschar was observed with repetitive application on shaved rabbit abdominal, it is described that it recovered completely within seven days after the end of exposure (EHC 177 (1996)). On humans, from the results of single exposure test on skin, it is judged to have serious stimulativeness (IUCLID (2000)), and other reports indicate severe irritation (EHC 177 (1996), PATTY (5th, 2001), ATSDR (1992)). From these information, this product may result in corrosion. So it was judged to have severe irritation, it was classified as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is irritation on the conjunctiva and necrotic slight for corneal surfaces by rabbits eye drops, it did not bequeath injury 12 days afterward, and had recovered completely (EHC 177 (1996)). Moreover, it is indicated that there is ocular severe irritation in humans (EHC 177 (1996)). Since it was judged that it had the moderates irritation from these information to an eye, it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Although there is a report (BUA 66 (1991)) which suggests sensitizing by humans, it cannot be said that the accuracy as a proof is sufficient, and since data is insufficient, it cannot be classified..	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	There are positive results from the DNA damage test using rat testicular cells (in vivo genotoxicity test in germ cells) and from several DNA damage tests and DNA binding tests using somatic cells such as hepatocytes from rats or mice (in vivo genotoxicity test in somatic cells) (IARC 71(1999), EHC 177(1996)). Furthermore, there are positive results in several parameters for the in vitro mutagenicity tests (IARC 71(1999), EHC 177(1996)). The substance was classified as Category 2 based on the above results.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It was set as Category 1B based on being classified into 2A (2002) according to industrial hygene society, and being classified into 2A (1999) according to IARC, respectively.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is the report about the failure of pregnancy in the mating between the male rat exposed with ten-week inhalation and the female rat no processing, and the decrease of mating formation in the mating between the female rat exposed with three-week inhalation and the male rat no processing (EHC 177(1996)). Since general toxicity (reduced weight gain, dead) occurs spontaneously in the dose causing these effects, it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (liver, kidney, central nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	Due to the descriptions that the liver fatty metamorphosis, centrilobular necrosis, and proximal convoluted tubules of kidneys were observed by suicide attempt or mistaking (EHC 177(1996), PATTY (5th, 2001), IARC 71(1999), ACGIH (2001), BUA 66 (1991)), and that centrilobular fatty change degenerations and necrosis in hepatic and renal tubule edema in liver were observed also in rat (EHC 177 (1996)). So it was classified into Category 1 (liver, kidney). Moreover, due to the descriptons that there are some reports which mistaking for the anesthetic in humans caused poisoning (ACGIH (2001), BUA 66 (1991)), furthermore, that it affects to central nervous systems and causes an awareness decreases is caused (ICSC (1993)), it was classified into Category 1 (central nervous system). In addition, it also classified into Category 3 (respiratory irritant) according to the description which also has irritaiton in airways (EHC 177 (1996), ICSC (1993)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs, liver, kidney)	Warning	H373	P260 P314 P501	It was classified in Category 2 (respiratory tracts) based on statements that not only stimulative to the pharynx and a bronchus (PATTY (5th, 2001)), but also lungs damage and bronchitis were affected in humans by occupational exposure (ICSC (1993)), and statements that a necrosis and atrophy of olfactory epithelium in nasal cavity, dysplasia, hyperplasia, and gigantocellularis of a squamous epithelium cell in a respiratory tract were seen in inhalation exposure of rats or mouse with the concentration (0.577 mg/L) equivalent to the guidance value Category 2 (EHC 177 (1996)) . Moreover, a potential that humans will also affect liver and the kidney as effect of long-term or repeated exposure is suggested (ICSC (1993)), and inhalation exposure of a guinea pigs with the concentration (0.385 mg/L (50 ppm) (80 days) (the equivalent on the 90 days: 0.342 mg/L)) as equivalent to the guidance value Category 2, mild centrilobular fatty degeneration in liver, interstitial congestion and edema in the kidney were observed (EHC 177 (1996)). On this bases, it was classified in Category 2 (liver, kidney).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour LC50 = 3.61 mg/L for crustacea (Ceriodaphnia dubia) (SIAP, Conclusions Agreed in CoCAM 2, 2012; Result of the initial environmental risk assessment of chemicals, Vol. 12, Ministry of the Environment in Japan, 2014), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 2 from lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1978)), and 48-hour LC50 = 3.61 mg/L for crustacea (Ceriodaphnia dubia) (SIAP, Conclusions Agreed in CoCAM 2, 2012; Result of the initial environmental risk assessment of chemicals, Vol. 12, Ministry of the Environment in Japan, 2014).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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