NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	106-99-0
Chemical Name	1,3-Butadiene
Substance ID	m-nite-106-99-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	From explosion limit (1.1-16.3% (ICSC (J) (2000))), it was classified in Category 1. Besides, the stabilized one is classified in Division 2.1 in UNRTDG (UN 1010). Besides, it is evaluated as "Not classified" as chemically unstable gas (UNRTDG Manuals of Tests and Criteria 5th Revised Edition, p.37).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified	- -	-	-	It is flammable gases (Dicision 2.1in UNRTDG).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	A boiling point is -4 deg C (ICSC (J) (2000)), and liquid phase exists partially at temperatures below that at normal pressures. Low pressure liquefied gas (a critical temperature 161.8 deg C (HSDB (Access on June 2017))).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	Based on a report of an LC50 value of 129,000 ppm in a 4-hour inhalation test with rats (ACGIH (7th, 2001), EU-RAR (2002), Hazard Assessment Report (CERI, NITE, 2008), ATSDR (2012)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a case report that skin frostbite was caused by contact with liquefied 1,3-butadiene (Hazard Assessment Report (CERI, NITE, 2008), ATSDR (2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There are reports that in eye irritation tests in which mice were exposed to this substance (gas) at 90,000-140,000 ppm and rabbits at 150,000-250,000 ppm, conjunctivitis or lacrimation occurred (EU-RAR (2002)), and there is a case of workers who were exposed to this substance (gas) at 2,000 ppm for 7 hours or at 4,000 ppm for 6 hours and showed eye irritation (ATSDR (2012), EU-RAR (2002)). Also, since it is considered to be irritating to the eyes of humans and animals, it was classified in Category 2. Besides, there is a description that since butadiene is in a gaseous state at room temperatures, it is impossible to conduct a conventional eye irritation test (EU-RAR (2002)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a mouse dominant lethal test was positive, a mouse reciprocal translocation test was positive, micronucleus tests with mouse bone marrow cells and peripheral blood were positive, micronucleus tests with rat bone marrow cells and peripheral blood were negative, a chromosomal aberration test with mouse bone marrow cells was positive, a chromosomal aberration test with rat bone marrow cells was negative, a mouse spot test was positive, transgenic mouse gene mutation tests were positive in bone marrow cells and spleen cells, a gene mutation test with mouse splenic T-lymphocytes was positive, a micronucleus test and a sister chromatid exchange test with mouse germ cells were positive, a sister chromatid exchange test with mouse bone marrow cells was positive, DNA damage tests with the liver, lung and testes of mice and rats were positive, and unscheduled DNA synthesis tests with the liver of mice and rats were negative (Hazard Assessment Report (CERI, NITE, 2008), CICAD 30 (2001), ATSDR (2012), EU-RAR (2002), CaPSAR (1999)). As for in vitro, bacterial reverse mutation tests were positive and negative results, a mouse lymphoma test with mammalian cultured cells was negative, sister chromatid exchange tests were positive and negative results (Hazard Assessment Report (CERI, NITE, 2008), ATSDR (2012), EU-RAR (2002)). From the above, it was classified in Category 1B according to the GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	The epidemiological studies in the styrene-butadiene rubber manufacturing industry indicated an excess of leukemia due to occupational exposure, and revealed it has a dose-response relationship with cumulative exposure to butadiene. In addition, in the studies in the butadiene monomer industry, excesses of leukemia and malignant lymphomas due to occupational exposure were shown (IARC 100F (2012)). On the other hand, as for experimental animals, in carcinogenicity tests with rats and mice exposed by inhalation, increases in tumor incidence in multiple organs were observed in females and males of both species (IARC 100F (2012)). IARC classified this substance in Group 1 as there is sufficient evidence of carcinogenicity in both humans and experimental animals (IARC 100F (2012)). Other than this, NTP classified it as K (NTP RoC (14th, 2016)), EPA as CaH (IRIS (2002)), and EU in Carc. 1A (ECHA CL Inventory (Access on June 2017)), and Japan Society For Occupational Health (JSOH) in Group 1 (Recommendation of Occupational Exposure Limits (2016): proposal in 2001), respectively. From the above, it was classified in Category 1A.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a test in which male mice were exposed by inhalation at 200-5,000 ppm for 5 days and were mated with untreated females, an increase in the number of females that showed intrauterine deaths was observed at or above 200 ppm (ATSDR (2012)). In addition, in the two tests in which male mice were exposed by inhalation at 65 ppm for 4 weeks or at 12.5 ppm for 10 weeks, and subsequently were mated with untreated females, an increase in early fatal death in the former, and an increase in late fetal death, exencephaly, and skeletal abnormalities in the latter were observed (ATSDR (2012)). On the other hand, in the developmental toxicity test in which pregnant rats or pregnant mice were exposed by inhalation at up to 1,000 ppm during organogenesis period (gestational day 6-15), no abnormality was observed in rats even in the 1,000 ppm exposure group, and only slight effects (low values of fetuses body weight, extra rib, delayed ossification) were observed in mice (ATSDR (2012), Hazard Assessment Report (CERI, NITE, 2008), EU-RAR (2002)). However, in a developmental toxicity test in which pregnant rats were exposed by inhalation at up to 8,000 ppm during the organogenesis period (gestational day 6-15), decreased body weight gain in maternal animals at or above 200 ppm, increased frequency of skeletal abnormality (wavy ribs) in fetuses at or above 1,000 ppm were observed, and at 8,000 ppm, increased frequency of major skeletal defects including the skull, vertebra, sternum, long bones, and ribs in the fetuses were observed additionally (ATSDR (2012), Hazard Assessment Report (CERI, NITE, 2008), EU-RAR (2002)). From the above, in the three tests in which male mice were mated with untreated females after inhalation exposure, increased fetus deaths were observed at a dose where no general toxicity effect was manifested in parental animals, and in one test among them, external malformations and skeletal abnormalities were observed. Skeletal abnormalities were also detected in the developmental toxicity tests where pregnant rats were exposed at high concentrations during an organogenesis period. Therefore, it was classified in Category 1B for this hazard class. Besides, since it was classified based on the new information source, the classification result was changed from the previous one.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	As for humans, there is a report that the workers who were exposed to this substance during handling in the rubber manufacturing plant complained of irritation of the nose and throat, and cough and drowsiness were also observed in some of them, but these symptoms disappeared when the exposure finished (EU-RAR (2002), ATSDR (2012)). Additionally, there is a report that in a test with volunteers, slight irritation and dryness of the nose and throat were observed by exposure at 10,000 ppm for 5 minutes (EU-RAR (2002)). As for experimental animals, there is a report that in a single inhalation exposure test with mice, no effect was observed at 100,000 ppm, but mild narcotic effects were observed at 150,000 ppm, and exposure at 200,000 ppm for 6-12 minutes lead to an anesthetized state after excitement (ACGIH (7th, 2001)). Also, there is a report that in a single inhalation exposure test with rats, exposure at 129,000 ppm for an hour lead to a deep anesthetized state (EU-RAR (2002)). Additionally, there is a report that in a single inhalation exposure test with rabbits, exposure at 250,000 ppm for 25-30 minutes lead to an anesthetized state followed by death, but the animals recovered rapidly in the case of exposure for an extremely short time (ACGIH (7th, 2001)). Moreover, there is a description that this substance has been known as a relatively weak central nervous system depressant for over 50 years (ACGIH (7th, 2001)). From the above information, it was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (reproductive organs (female)), Category 2 (heart, blood system, liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	No information on humans is available. As for experimental animals, there is a report that in 2-year inhalation toxicity tests with mice, ovarian atrophy at or above 6.25 ppm within the guidance value range for Category 1, a decrease in the survival rate at or above 20 ppm, thymus atrophy, myocardial mineralization, macrocytic anemia, centrilobular necrosis of the liver at or above 62.5 ppm within the guidance value range for Category 2, and bone marrow atrophy and testicular atrophy, etc. at 625 ppm exceeding the guidance value range for Category 2 were observed (Hazard Assessment Report (CERI, NITE, 2008), NTP TR434 (1993)). Therefore, it was classified in Category 1 (genetic organs (women)), Category 2 (heart, haemal system, liver). Besides, in the previous classification, the bone marrow and testes were adopted as the target organ for Category 2. However, reconfirmation revealed that this was a finding at a dose exceeding the guidance value of Category 2, therefore, the classification result was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Reliable acute toxicity data were not obtained	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information