NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	107-20-0
Chemical Name	chloroacetaldehyde
Substance ID	m-nite-107-20-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point 190 degF (87.7 degC) (closed-cup) (Sax (11th, 2004), HSDB (2009)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive and self-reactive properties. As relevant notes, it is reported that the pure substance may polymerize when it is left standing (Merck (14th, 2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is reported 88 degC (HSDB (2009)), it was judged that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen which are chemically bonded only to carbon.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Six LD50 values for rats of 23 mg/kg (ACGIH (2001)), 89 mg/kg (PATTY, 5th (2001)), 110.5 mg/kg, 127.5 mg/kg, 133 mg/kg and 98 mg/kg (the above four were from DFGMAK-Doc. 12 (1999)) were reported. One of them corresponded to Category 2, and the other five corresponded to Category 3. The substance was classified as Category 3, as the most of the data corresponded to it.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Three LD50 values of 67 mg/kg (ACGIH (2001)), 267 mg/kg (PATTY, 5th (2001)) and 330.2 mg/kg (DFGMAK-Doc.12 (1999)) for rabbits were reported. One of them corresponded to Category 2, and the other two corresponded to Category 3. Since the number of the corresponding value was larger, the substance was classified as Category 3. For rats, two LD50 values of 140 mg/kg and 129 mg/kg (both from DFGMAK-Doc. 12 (1999)) were reported and they corresponded to Category 2. Therefore, the substance was classified as Category 2. From the results mentioned above, based on the rat data with greater hazard, the substance was classified as Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	The rat LC50 values of 202.5 ppmV/1h (103 ppmV/4hrs) (PATTY, 5th (2001)), 202.5 - 243 ppmV/1h (103 - 121 ppmV/4hrs), < 25 ppmV/7hrs (< 33 ppmV/4hrs), < 50 ppmV/3.5hrs (< 46.7 ppmV/4hrs) and < 100 ppmV/2hrs (< 70.7 ppmV/4hrs) (the above four are from (DFGMAK-Doc. 12 (1999)) were reported. Two of them corresponded to Category 2, and the other three corresponded to Category 1. The substance was classified as Category 1, since the majority of obtaining data corresponded to it. As the LC50 value was lower than 90% of the saturated vapor pressure concentration (84605 ppmV), it was judged as "vapor hardly coexisting mists" and the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was classified as "C; R34" in the EU classification (EU-Annex I (Access on Jun. 2009)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In the rabbit test, instillation of 30% aqueous solution of the substance to the eyes caused severe damage (ACGIH (2001)). In human cases, 40% aqueous solution poured into eyes caused the serious hazard of injury, containing tissue destruction (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was noted as corrosive to skin.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	In the guinea pig maximization test (Magnusson-Kligman test), the non-irritating concentration of 0.002% of the substance did not cause skin sensitization (DFGMAK-Doc.12 (1999)). However, since details of test results such as positive rate and conclusion of sensitization were not provided, the classification was not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	This substance is a bifunctional alkylating metabolite produced by metabolism of vinyl chloride, and it is considered to be the ultimate carcinogenic form. Considering the characteristics of the substance and similarity with acetaldehyde, possibility of Category 2 is suggested. However, there were no positive results in vivo tests (negative results in the DNA strand break test (in vivo genotoxicity test in somatic cells) using the livers or spleens of mice and rats orally administered (DFGMAK-Doc.12 (1999))) and no supporting data was available for Category 2. Therefore, the classification was not possible due to lack of data. As relevant information, as for in vitro studies, positive results in multiple Ames test (NTP DB (Access on Jun. 2009), DFGMAK-Doc.12 (1999)), in the chromosome aberration test using CHL cells (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)) and in the HPRT test using human lymphoblastoid cells (DFGMAK-Doc.12 (1999)) were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	The carcinogenicity criterion is "Carc. Cat. 3; R40" (EU-Annex I (Access on Jun. 2009)) in the EU classification, but its evidence is not clear. In the animal study, on the other hand, in the 2-year administration study via drinking water in male mice, no effects on the mortality were detected, but an increase in the incidence of liver tumors was reported as the only neoplastic changes associated with the administration, and the incidence of liver cancer and total of incidences of adenomas, carcinomas and nodules of the liver increased compared to background control (DFGMAK-Doc.12 (1999)). Therefore, the substance was classified as Category 2 judging comprehensively from the MOA. As relevant information, no evidence on carcinogenicity were indicated in the oral administration study in mice for 630 - 636 days at the dose level of 12.5 mg/kg dosing once a week, and in the dermal administration study in mice for 581 days at the dose level of 50 mg/kg dosing three times a week (DFGMAK-Doc.12 (1999)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, systemic)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In the acute inhalation toxicity study in rats exposed to vapor (LC50 value: 0.65 mg/L/1hr = 0.33 mg/L/4hrs), in addition to the signs such as salivation, nasal discharge and dyspnea, etc., pulmonary edema, atelectasis and hydrothorax were noted in the autopsy of the dead animals (DFGMAK-Doc.12 (1999)). Based on the information and judging from the guidance value (estimated from LC50 value), the substance was classified as Category 1 (respiratory system). Moreover, in the acute oral toxicity study in rats (LD50 value: 98 - 133 mg/kg), signs such as reduced activity, irregular breathing, and dazed behavior were observed, and in the acute dermal toxicity study in rats (LD50 value: 129 - 140 mg/kg) signs such as reduced activity, tremor, ataxia, dyspnea, deterioration of the general state of health were also observed (DFGMAK-Doc.12 (1999)). The effects in both routes partly included symptoms of the respiratory system. However, since those effects in combination with deaths occurred at the dose range within Category 1 of the guidance values (estimated from LD50 values in both oral and dermal routes), and since it was difficult to specify the target organs for the effects other than respiratory system, the substance was classified as Category 1 (systemic toxicity). Besides, it was reported in humans that serious hazard from exposure to the vapors was noted, and that the mucous membranes of the nasal and oral cavity and the upper respiratory tract were affected, producing a burning sensation, bronchial constriction, choking and coughing (ACGIH (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	At the interim examination after 30 weeks in the 2-year oral study via drinking water in mice at average dose level of 17 mg/kg/day, it was reported that the incidence of non-neoplastic changes (vacuolation, cytoplasmic changes, cytomegaly, chronic inflammation, hyperplasia, and necrosis) in the liver was increased accompanied by increased liver weights (DFGMAK-Doc.12 (1999)). Based on the information and judging from the guidance values, the substance was classified as Category 2 (liver). In addition, it was reported that the only treatment-related neoplastic changes were the liver tumors at the examination after 2 years (DFGMAK-Doc.12 (1999)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 96h-LC50 = 42.7 micromol/L (3.35 mg/L) for fish (Danio rerio) (AQUIRE, 2010).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and its rapid degrability is unknown.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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