NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	107-25-5
Chemical Name	Vinyl methyl ether
Substance ID	m-nite-107-25-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Flammable range is 1.9 - 32.0% (Ullmanns (E) (6th, 2003)) and it is applicable more than 12%. And it is rated as Division 2.1 in UNRTDG (UN1087), therefore it is classified into Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified	- -	-	-	Since the substance is classified as Division 2.1 in UNRTDG (UN1087), it is not an oxidizing gas.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	The substance is gas and its critical temperature is 167.85 degC (Matheson (7th, 2001)) which exceed +65 degC.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the rat LD50 value of 3660 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 value of >8000 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	Based on the results that 4-hour exposure at 64000 ppm to 6 rats caused no mortality (IUCLID (2000)) and the rat LC50 value was > 5.3 mg/L/4hrs (> 2202 ppm/4hrs) (IUCLID (2000)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	In the rabbit test, no irritation was reported (IUCLID (2000)). But the substance was classified as "Classification not possible" because the substance is gaseous (boiling point is 12 degree centigrade) and no details of testing methods were provided. As relevant notes, liquid or concentrated vapor of the substance revealed frostbite to the human skin (HSDB (2002)). It was also reported that contact with the substance revealed burn of the skin and direct skin contact might cause frostbite (HSFS (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	In the rabbit test, no irritation was reported (IUCLID (2000)). However the substance was classified as "Classification not possible" because the substance is gaseous (boiling point is 12 degree centigrade) and no details of testing methods were provided. As relevant notes, liquid or concentrated vapor of the substance caused eye irritation (HSDB (2002)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow obtained from mice exposed by inhalation (in vivo mutagenicity test in somatic cells) (IUCLID (2000)). These results mentioned above were obtained from retrial study. In the former test using male and female mice in accordance with the similar protocol, clear results were not obtained though due to the increase in micronuclei in males at the high dose (IUCLID (2000)). As relevant information, as for in vitro study, negative results in the Ames test were reported (IUCLID (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was described that ethers generally had narcotic action and it was indicated that structurally similar vinyl ethers (the substance and isopropyl vinyl ether) possessed depressive action of central nervous system and anesthetic action in the laboratory animals (HSDB (2002)). In addition, as symptoms following exposure to humans, headache, dizziness, excitation, loss of consciousness were described (HSDB (2002)). Based on the information, the substance was classified as Category 3 (narcotic effects).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In the 28-day inhalation toxicity study in rats (OECD TG 412, GLP-compliant) exposed to the substance at the concentrations of 500, 3500 and 25000 ppm, slight prolongation of prothrombin time and slight decrease in total protein concentration were observed in males of all treatment groups. The signs consisting of restlessness and piloerection, and changes in the liver weight were observed in the highest dose level (25000 ppm), and suppression of body weight gain was observed in the doses of 3500 ppm or more. However, no remarkable changes were found at necropsy. The only histopathological change was atrophy of the nasal olfactory epithelium in the highest dose group. The NOAEL of 3500 ppm (converted concentration as that of 90-day study: 1089 ppm) was reported for females (IUCLID (2000)). For males, the effects at 3500 ppm were slight, and in another 28-day inhalation toxicity study in male rats (OECD TG 412, GLP-compliant), no effects as described above were noted, and the NOAEL of 1500 ppm (converted concentration as that of 90-day study: 467 ppm) was reported (IUCLID (2000)). Based on the information, since the substance was gasiform by definition of GHS and the NOAELs in the 28-day repeated inhalation studies in rats (OECD TG412, GLP-compliant) were over the upper limit (250 ppm) of the range of the guidance values, "Not classified" was justified.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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