NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	107534-96-3
Chemical Name	1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol
Substance ID	m-nite-107534-96-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It contains oxygen and chlorine, which are chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Of its rat LD50 values documented: 1700, 3350, 3930, 4000, 4260, and > 5000 mg/kg bw (JMPR No. 884 (1994)), "Not classified" category was represented by the largest number of values (from 3350 to > 5000 mg/kg). Thus, the substance was classified into "Not classified" using the JIS classification criteria. Also, all LD50 values documented above except for > 5000 mg/kg fall under Category 5 in the United Nations classification.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Its rat LD50 values are > 5000 and > 2000 mg/kg bw (JMPR No. 884 (1994)) and both values fall under "Not classified" category. Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Of its rat LD50 values documented: 0.818, 0.371, and 5.093 mg/L (JMPR No. 884 (1994)), each of them represents Category 2, Category 3, or "Not classified". Selecting the value representing the highest toxicity, the substance was classified into Category 2. Regarding its LD50 value of 0.818 mg/L, since the test concentration of > 818 mg/m3 (= > 0.818 mg/L) was higher than its saturated vapour pressure concentration of 27.70*e-11 (mg/L) at 25degC, we judged that the experiment was conducted in dust/mist state.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since all three separate dermal irritation tests using rabbits that underwent 4-hour application gave negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In rabbit tests, application of 50 mg caused no irritation (JMPR No. 884 (1994)), and application of 100 mg caused slight irritation (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	Maximization tests using guinea pigs could not determine whether the substance is sensitizing, while the tests using the Buehler method gave negative results. However, since other tests using the maximization method or Buehler method (both are GLP tests) both gave negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results acquired in both dominant lethal tests using mice that underwent oral administration and micronucleus tests (both are in vivo mutagenicity tests using somatic cells) (JNPR No. 884 (1994)), the substance was classified into "Not classified". Regarding in vitro mutagenicity tests, both Ames tests and mutation tests using CHO cells gave negative results (JMPR No. 884 (1994)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	In 2-year oral administration tests using rats, no increase in tumorigenesis was detected, whereas in 21-month oral administration tests using female mice, a significant increase in rates of developing hepatic adenoma and carcinoma were discovered (JMPR No. 884 (1994)); thus, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In oral administration tests using rats conducted during the organogenetic period, an increased post-implantation loss, increased incidences of peromelia, agenesis of claws, and cleft palates were detected at the doses associated with suppressed body weight gain in maternal animals (JMPR No. 884 (1994)). In addition, in other oral administration tests using rats conducted during the organogenetic period, a decreased reproduction rate, increased in number of underdeveloped animals, and increased microphthalmia were detected at the doses associated with suppressed body weight gain in maternal animals (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In oral administration tests using rats, a state of sedation was observed in female rats at 950 mg/kg and male rats at 1600 mg/kg, and the symptom disappeared in 2 days. Similarly, in other tests, a state of sedation was observed and disappeared in 3 days. In addition, in other tests, lowered activities, prone posture, recumbency, and slowed reflexes were detected at Category 2 guidance doses; and in mice a lowered rate of activity, slowed reflexes, prone posture, and recumbency were also detected at Category 2 guidance doses (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)). Based on these results, the substance was classified into Category 2 (nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (eye)	Warning	H373	P260 P314 P501	One-year oral administration tests using beagle dogs (12 females and 12 males) found that NOAEL for cataract induction is 4.5 mg/kg (JMPR No. 884 (1994)). In other tests using beagle dogs that were treated with doses above this NOAEL value, lens opacities were observed in 2 dogs treated with 10 mg/kg/day and one dog treated with 60 mg/kg/day during the weeks 26 and 32 of the test period (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2 (eyes). In other reports, oral administration tests using rats found fatty changes in the liver, bile-duct proliferation, and enlargement of the centrilobular hepatocytes (JMPR No. 884 (1994)); however, we considered these could be adaptive changes and did not use these results as grounds for classification. Also, sclerosis of the red pulp of the spleen, associated with sideropenia was mentioned in the same study; however, since no details were provided, we did not use this report either.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 96-hour LC50 is 0.49 mg/L for crustaceans (mysids) (AQUIRE, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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