NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	108-87-2
Chemical Name	Methylcyclohexane
Substance ID	m-nite-108-87-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -4 deg C (closed cup) and a boiling point of 101 deg C (ICSC (J) (1997)). Besides, it is classified in Class 3, PG II in UNRTDG (UN2296).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 250 deg C (NFPA (2010)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Not classified	- -	-	-	It was classified as "Not classified" from information that steel and aluminum are resistant as containers (Hommel (1991)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it corresponds to Category 4 or "Not classified." Therefore, it was classified as "Classification not possible" since the category could not be specified. The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) LD50 for rats: > 1,000 mg/kg (NITE Toxicity and Eco-toxicity Tests (Access on September 2019)) (2) LD50 for rats: > 3,200 mg/kg (GESTIS (Access on October 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	[Rationale for the Classification] Based on (1), it was classified in Category 4. Besides, since the exposure concentrations were lower than 90% of the saturated vapor pressure concentration (about 60,531.1 ppm), a reference value in the unit of ppm was applied as a vapour with little mist. The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) Inhalation test with mice (2 hours): 10,000-12,500 ppm (converted 4-hour equivalent value: 7071.1-8838.8 ppm) (ACGIH (7th, 2001), PATTY (6th, 2012), OEL Documentations (Japan Society For Occupational Health (JSOH), 1986)) [Reference Data, etc.] (2) LC50 for rabbits (70 minutes): 39.6-59.9 mg/L (converted 4-hour equivalent value: 21.4-32.35 mg/L, 5328.8-8055.4 ppm) (SIDS (2014)) (3) Inhalation test with rabbits (70 minutes): all animals were dead at 15,227 ppm (converted 4-hour equivalent value: 8223.6 ppm) (ACGIH (7th, 2001))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." The category was changed because new data were obtained. [Evidence Data] (1) In a skin irritation test with rabbits for this substance, no edema was observed, and very slight erythema reactions were observed at 24 hours post-application, but they were reversible (SIAP (2014)). (2) This substance is slightly irritating to the mucous membranes and is irritating to the skin for direct contact (GESTIS (Access on September 2019)). [Reference Data, etc.] (3) In a skin irritation test in which this substance was applied to rabbits occlusively for 24 hours according to the Draize method, slight irritation was observed in 4/5 animals at 24 hours post-application and disappeared after 72 hours in all but one animal. Besides, no edema was observed. The mean scores of erythema and edema at 24/72 hours were 0.6 and 0, respectively (REACH registration dossier (Access on October 2019)). (4) It was classified as "Skin Irrit. 2 (H315)" in the EU-CLP classification (EU CLP classification (Access on September 2019)). (5) Repeated application of this substance to the skin of a rabbit caused local irritation, thickening, and ulceration (ACGIH (7th, 2001)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	[Rationale for the Classification] Based on (1), it was classified in Category 2B. [Evidence Data] (1) In an eye irritation test (similar to OECD TG 405) of this substance with rabbits, conjunctival redness was observed at 1 hour and 24 hours post-application, but it was fully reversible after 48 hours (SIAP (2014), REACH registration dossier (Access on October 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] There is a description of (1), but it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) There are no data on this substance. However, since cyclohexane (CAS RN 110-82-7), an analogue of this substance, was not sensitizing in a skin sensitization test (OECD TG 406) with guinea pigs, it is assumed that this substance is also not sensitizing (SIAP (2014), REACH registration dossier (Access on October 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, negative results were reported in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (NITE Toxicity and Eco-toxicity Tests (Access on September 2019), JECDB (Access on September 2019), SIAP (2014)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] No reproductive effects were observed in (1), but it was a screening test and there were no data on developmental toxicity. Therefore, it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, no reproductive effects were observed even at doses where parental toxicity (increased liver weight in males and females and hyaline droplets in the epithelium of the renal tubules (not due to alpha 2u globulin accumulation) in males) was observed (JECDB (Access on September 2019), SIAP (2014)). Besides, regarding the effects on pups, it was described in the test report that at the highest dose, 1,000 mg/kg/day, a lower body weight and a lower survival rate on the postnatal day 4 were observed (JECDB (Access on September 2019)), but it was described in SIAP (2014) that no effects were observed in pups.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 3 (narcotic effects, respiratory tract irritation). The classification result was changed from the previous classification by the use of new information sources. [Evidence Data] (1) It is reported that in humans, inhalation of the substance causes lightheadedness, drowsiness, and irritation of the nose and throat. And, there is a report that vapors of this substance cause a brief central nervous system depression (PATTY (6th, 2012)). (2) In single 1-hour inhalation exposure tests with rats and mice, hyperactivity, loss of coordination, and prostration were observed, but no deaths were observed (SIAP (2014)). [Reference Data, etc.] (3) In a test in which rabbits were exposed by inhalation to 59.9 mg/L (converted 4-hour equivalent value: 32.4 mg/L, exceeding the range of Category 2) for 70 minutes, severe convulsions, rapid narcosis, labored breathing, salivation, and conjunctival congestion were observed before death (SIAP (2014), ACGIH (7th, 2001)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1) and (2), effects on the kidney are observed within the range of Category 2 in oral administration to rats, and immunostaining results indicate that these effects are not due to accumulation of alpha 2u globulin accumulation. Therefore, it was classified in Category 2 (kidney). The classification result was changed from the previous classification by the examination using the new information sources. [Evidence Data] (1) In a 28-day repeated dose toxicity test with rats dosed by gavage, a hyaline droplet in the kidney (reversible) was observed in males at or above 300 mg/kg/day (converted guidance value: 93 mg/kg/day, within the range of Category 2), and increased liver weight and hypertrophy of hepatocytes in both sexes and hyaline droplet (non-reversible), etc. in females were observed at 1,000 mg/kg/day (converted guidance value: 311 mg/kg/day, exceeding the range of Category 2) (SIAP (2014), NITE Toxicity and Eco-toxicity Tests (Access on September 2019)). (2) In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, hyaline droplet in the renal tubules (immunostaining results do not indicate that this was due to alpha 2u globulin accumulation) in males at or above 250 mg/kg/day (converted guidance value: 78 mg/kg/day, within the range of Category 2), and increased ALT and total cholesterol, increased liver weight and kidney weight, etc. were observed in males and females at 1,000 mg/kg/day (converted guidance value: 311 mg/kg/day, exceeding the range of Category 2) (SIAP (2014), NITE Toxicity and Eco-toxicity Tests (Access on September 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) It is a hydrocarbon. (2) Because of the kinematic viscosity of 0.89 mm2/sec at 25 deg C (calculated from the viscosity of 0.685 mPa*s (Handbook of solvents (2004)) and the density of 0.7694 g/cm3 (Handbook of solvents (2004))), the kinematic viscosity at 40 deg C is 20.5 mm2/s or less.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.33 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2006)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 because it was not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), and due to 72-hour NOEC (r) = 0.067 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2006)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 because it was not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), and due to 48-hour EC50 = 0.33 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2006)). From the above results, it was classified in Category 1.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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