Item | Information |
---|---|
CAS RN | 108-98-5 |
Chemical Name | Thiophenol |
Substance ID | m-nite-108-98-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
The flash point is 50degC (Gangolli (2nd, 1999)). Classified into Class 3 and Division 6.1 (UN#2237) (UN Recommendations on the Transport of Dangerous Goods) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive or self-reactive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Easily catches fire when heated according to HSDB (2006). Classified into Class 3 and Division 6.1(UN#2337) (UN Recommendations on the Transport of Dangerous Goods) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine and chlorine | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no "-O-O-" structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Not classified |
- |
- | - | Classified into Class 3 and Division 6.1 (UN#2337) (UN Recommendations on the Transport of Dangerous Goods) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on the rat LD50 (oral route) value of 46mg/kg (CERI Hazard Data 99-2 (2000)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Based on the LD50 value of 134mg/kg representing the lower of the two testing data, the rat LD50 (dermal route) value of 300mg/kg (CERI Hazard Data 99-2 (2000)) and the rabbit LD50 (dermal route) value of 134mg/kg (CERI Hazard Data 99-2 (2000)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on the rat LC50 (inhalation of vapour) value of 33ppm (4 hours) (CERI Hazard Data 99-2 (2000) was lower than 90% of the saturated vapour concentration (1,320ppm) under a saturated vapour pressure of 0.133kPa (18.6degC) (CERI Hazard Data 99-2 (2000)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on the description in the report on animal skin irritation tests (CERI Hazard Data 99-2 (2000)): "severe irritation of the skin" (though exposure duration is unknown). Also based on the description in PATTY (4th, 2000): "Dermal application of the substance induced inflammatory responses, with effects resolving by 24-48 hours." The substance is thus considered a skin irritant. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 99-2 (2000) and PATTY (4th, 2000)): "Severely irritating, causing conjunctival irritation and corneal lesions," "moderate to severe conjunctival injection, edema and discharge persisted for 3-4 days and healed by day 16 in all affected animals. Corneal opacity progressed on days 16-19, with gradual recovery observed in subsequent 1.5-2 months." The substance is thus considered severely irritating and classified into Category 2A. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
Based on the evidence of external anomaly in pups at doses inducing maternal toxicity in rat teratogenicity tests, described in NTP DB (Access on Feb., 2006), CERI Hazard Data 99-2 (2000). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system), Category 3 (respiratory tract irritation) |
Warning |
H371 H335 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
Based on the human evidence including "choking, irritation of the eye/nose, headache" (MOE Risk Assessment vol.4 (2005)), and the evidence from animal studies including "somnolency, coma, dyspnea", "irritation of the respiratory organs," "ataxia," "muscular weakness, ataxia, cyanosis" (RTECS (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Based on the evidence from animal studies including "renal tubular degeneration observed at 9, 18mg/kg" (ACGIH (7th, 2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 48-hour EC50 = 0.0044 mg/L for crustacea (Daphnia magna) (Ecotoxicity tests by Environment Agency, 1999), it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 2002)), and 21-day NOEC < 0.0020 mg/L for crustacea (Daphnia magna) (Ecotoxicity tests by Environment Agency, 1999). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 2002)), and 96-hour LC50 = 0.009 mg/L for fish (Oryzias latipes) (Ecotoxicity tests by Environment Agency, 1999). It was classified in Category 1 from the above results. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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