Item | Information |
---|---|
CAS RN | 108-99-6 |
Chemical Name | 3-Methylpyridine |
Substance ID | m-nite-108-99-6_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
From a flash point of 38 deg C (closed cup) (ICSC (1999)), it was classified in Category 3. It is classified in Class 3, PG III (UN2313, Picolines) in UNRTDG. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 500 deg C (Slovent pocket book (1997)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on the LD50 values of 400 to 800 mg/kg for rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), and 400 mg/kg for rats (NTP TR580 (2014)), this substance was classified in Category 4. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
It is reported that the LD50 values for rabbits were 800 to 2,000 mg/kg (PATTY (6th, 2012)). Since these values correspond to Category 3 to 4, the category with the higher hazard was adopted. It was classified in Category 3. Although it is reported that the LD50 value for rabbits is < 1,000 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), therefore, it was not adopted for the classification since it is not possible to specify the category from this value. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
It is reported that the LC50 (4 hours) values for rats were 1,300 to 3,300 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), PATTY (6th, 2012)). Since these values correspond to Category 3 to 4, the category with the higher hazard was adopted. It was classified in Category 3. Since the LC50 value is less than 90% of the saturated vapor concentration (7,985 ppm), a reference value in the unit of ppm was applied as vapor without mist. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Since in a skin irritation test using rabbits (applied for 4 hours), a corrosive nature was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), this substance was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
Severe irritation was observed in eye irritation tests using rabbits, and symptoms were also observed after 21 days (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), therefore, this substance was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | It is described in Chemical Substance Hazard Data (CERI, 2002) that the skin sensitization was not shown in a skin sensitization test using guinea pigs. However, because there is only the one report, it was classified as "Classification not possible." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | This substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, micronucleus tests using peripheral blood from mice were negative (NTP TR580 (2014)). As for in vitro, bacterial reverse mutation tests and a mammalian cell gene mutation test were negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), NTP TR580 (2014), PATTY (6th, 2012), HSDB (Access on June 2016)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
In a 2-year carcinogenic study using rats or mice administered orally (drinking water), in rats, an increase in the incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) were observed in females, but no increase in tumors was observed in males, and in mice, an increase in alveolar/bronchiolar adenoma in males were observed, along with increase in incidences of hepatocellular adenomas or carcinomas, and combined incidence of hepatocellular adenomas or hepatoblastoma, increase in the incidence of alveolar/bronchiolar carcinoma and increase in the incidence of alveolar/bronchiolar adenoma or carcinoma (combined) in females were observed (NTP TR580 (2014)). From the results of this study, it was concluded that for carcinogenicity there is no evidence in male rats, some evidence in female rats, equivocal evidence in male mice and clear evidence in female mice (NTP TR580 (2014)). In addition, NTP considered that, in this discussion, the lung is the target organ for this substance, and that lung tumors found in female rats and male and female mice were induced by this substance (NTP TR580 (2014)). Therefore, considering the weight of evidence, it was judged to be appropriate that this substance was classified in Category 2. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
There is a description that the vapor of this substance is irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)). Also, in acute toxicity studies using rats, mice or rabbits administered by oral, inhalation or dermal, symptoms including lethargy, loss of consciousness, prostration, labored breath, abnormal gait and loss of the righting reflex were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Therefore, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects). In a previous classification, based on two case reports on a worker who was exposed to the vapor of this substance and showed autonomic disturbances, bradycardia, hypotonia, and mild central nervous system disturbances etc. (the Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), PATTY (6th, 2012)), the substance was classified in Category 1 (nervous system). However, as a result of careful examination of the data, it was found that the original papers are the same and it is highly possible that these cases are the same one. It was judged that one case was not enough for evidence to adopt the nervous system as the target organ, and the classification result was changed. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) |
Danger |
H372 | P260 P264 P270 P314 P501 |
As for humans, in occupational exposure, in a male worker exposed by mainly this substance for 11 years without exposure protection measures, headaches, nausea, right hypochondralgia, aphonia and rash were seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). It is also reported that increases in ALT activity and AST activity and bilirubinemia, suggesting hepatocyte toxicity were observed. These findings suggest the possibility of liver disorder in humans (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). In addition, for this case, increases in (S) GOT activity and in (S) GPT activity were reported in Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), PATTY (6th, 2012). As for experimental animals, there are not enough reports. It is reported that in a 2-week repeated exposure study using rats by inhalation, there were no effects other than increase in liver weights, which had recovery properties (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)). As described above, it was classified in Category 1 (liver) because it showed the possibility of effects on the liver in humans. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 72-hour EC50 = 15 mg/L for algae (Pseudokirchneriella subcapitata) (Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)), it was classified in Category 3. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (a degradation rate by BOD: 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), 72-hour NOEC (r) = 1.0 mg/L for algae (Pseudokirchneriella subcapitata), and 21-day NOEC (reproduction) = 1.0 mg/L for crustacea (Daphnia magna) (both Initial Risk Assessment (NITE, CERI, NEDO, 2007), Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1996), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not rapidly degradable (a degradation rate by BOD: 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), but no bioaccumulation is estimated (BCF was < 2.2-< 3.0 and < 24-< 29 when test concentration was set at 0.50 mg/L and 0.05 mg/L (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 96h LC50 for fish (Oryzias latipes) is >100 mg/L (Initial Risk Assessment (NITE, CERI, NEDO, 2007), Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1996), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). It was classified in Category 2 by drawing a comparison between the above results. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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