NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	110-00-9
Chemical Name	Furan
Substance ID	m-nite-110-00-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 1	Danger	H224	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since the flash point by Merck(14th,2006) is -35degC(closed type) and the boiling point is 31.36degC, it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 390degC (Merck KGaA data from March 2009)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification is not possible because there is no data. In addition, the European Union classification is Xn; R22 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Since it is written that saturated vapor pressure level of this substance (20degC)is 650,000 ppm, and LC50 value in the 1-hour inhalation exposure test employing rats is 3,464 ppm (HSDB (2003)), the gas standard is applied. Since 4-hour LC50 value is 1,732 ppm, it was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Although there is a description, "skin irritation"in the study with guinea pig in HSDB (2003)), this datum is not adopted, because examination of this cited literature (Gig. Saint. 6 (1974)) contained a description, "Since Furan has strong volatility (boiling point: 32degC), irritation was not examined." In addition, there is a description, "primary irritation" in the dermal administration test with rabbits in RTECS (2008), but it is an information source of List3 with details unknown. Therefore, classification is not possible, because data are insufficient. Incidentally, EU division is Xi; R38 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Although there is a description of "Irritation and burns may be caused by contacting to eyes" (HSFS (2008)), this is the information source of List3 and the details are also unknown. Therefore, since data is insufficient, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Although it has been described that the influence on the immune system including an allergic reaction was indicated in the inhalation exposure tests employing rats (RTECS (2008)), classification is not possible because of insufficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although it has been described that the allergic reactions were observed in the skin painting study employing guinea pig (HSDB (2003)), classification is not possible because of insufficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Although there is a description of the body cell in vivo mutagenicity test (chromosome aberration test employing the mouse bone marrow cell) being positive (IARC 63 (1995), NTP DB (Access on November 2008)), since there was no result of the in vivo genotoxicity testgenotoxicity test employing a germ cell, it was classified into Category 2. In addition, EU classification is Muta. Cat. 3; R68 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Since it was estimated as group 2B (IARC 63 (1995)) in IARC, it was classified into Category 2. In addition, there are descriptions of hepatic adenoma and glandular cancer in mice, of hepatic adenoma, cholangiocellular carcinoma, mononuclear cell leukemia in male and female rats, and of hepatocellular carcinoma in male rats (IARC 63 (1995), NTP TR402 (1993), NTP Roc (11th, 2005)). In addition, the European Union classification is Carc.Cat.2; R45 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system, gastrointestinal system, liver), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	About humans, HSDB (2003) has a description of "control of a central nervous system, the congestion of a digestive organ, liver damage, low blood pressure, fatigue, and headache" as conditions caused by inhalation exposure. Moreover, "There is Respiratory tract irritation" is described by ICSC (1995). Therefore, it is classified into Category 2 (a central nervous system, an digestive system, liver) and Category 3 (Respiratory tract irritation). In addition, primary literature (NTP Executive Summary: Furan (Draft) (1986)) of HSDB (2003) could not be obtained, and it was not able to check for details.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, respiratory system), Category 2 (testis, ovary)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	There is a description of "liver problems (fault formation, chronic inflammation, biliary fibrosis, vacuolar degeneration and denaturation, necrosis, etc.) and kidney trouble (extension of a nephric tubule, epithelium necrosis)" (NTP TR402 (1993)) in the two years oral administration test (maximum dose: 8 mg/kg) employing mice and rats. Moreover, in the 13-week oral administration test employing rats, there is a description of "Atrophy of testis and ovarian was seen" in 60 mg/kg group (NTP TR402 (1993)). Furthermore, RTECS (2008) has been described as "structural abnormality or functional abnormality of the trachea and bronchus"in the 60 days inhalation exposure test employing rats, and in the 26-week inhalation exposure test using rats, there is a description of "abnormalities to the central nervous system." and when these primary literatures (Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.9 (1967), Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.10 (1968)) were checked, former tracheal or bronchial abnormality had the dosage of guidance value within the range of Category 1 and was the symptom with localized emphysema, however, since the latter central nervous system abnormality was considered to be the symptom in fatality dosage, it was not adopted. As mentioned above, it was classified into Category 1 (liver, the kidney, respiratory system) and Category 2 (testis, ovaria).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified into Category 3 from 96 hours LC50=61mg/L of the fish (Fathead Minnows) (AQUIRE (2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Although acute toxicity was Category 3 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 4% (Existing Chemical Safety Inspections Data (1983))), since 31-33 days NOEC(the fish (Fathead Minnows))=8.27mg/L (AQUIRE (2008)) and long-term toxicity was >1mg/L, it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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