NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	110-88-3
Chemical Name	1,3,5-trioxan; trioxymethylene
Substance ID	m-nite-110-88-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Category 1	Danger	H228	P370+P378 P210 P240 P241 P280	The substance is rated as UNRTDG 4.1 II*ERG 133.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Since its autoignition point of 410degC (Ullmanns (E) (6th, 2003) vol. 15 p.24-27) is above 70degC, the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen, which is bonded only to carbon.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Its rat LD50 values of 8190-9500 mg/kg bw (GESTIS (accessed in October 2008)) fall under the "Not classified" category. However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available. Because this substance is easily hydrolyzed to form formaldehyde, see also the classification of formaldehyde (NITE publication ID69 (accessed in January 2009)) in relation to the following discussions on toxicity of this substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Its rabbit LD50 values of > 3980 mg/kg and > 15000 mg/kg (GESTIS (accessed in October 2008)) fall under the "Not classified" category. However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	4-hour exposure tests using rats have been conducted in which doses of 6.5 mg/L (1523 ppm) and 26 mg/L (7072 ppm), which are above Category 3 values, were tested (GESTIC (accessed in October 2008)); but since mortality and LC50 information is not provided, classification was not possible based on this study. Given that its saturated vapour concentration is ca. 23000 ppm or 84 mg/L at 25degC, the study was conducted in a vapour state with almost no included mists.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Rabbit or guinea pig tests (OECD TG 405) found that the substance is not irritating (GESTIS (accessed in October 2008)). However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Rabbit tests found that the substance is slightly eye irritating (GESTIS (accessed in October 2008). However, no detailed explanations were provided and no other studies are available. Thus, classification is not possible due to insufficient data available. This substance is easily hydrolyzed to form formaldehyde (classification: Category 2A, NITE publication ID69 (accessed in January 2009)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Guinea pig tests (OECD TG 406) found that the substance was not skin sensitizing (GESTIS (accessed in October 2008)). However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification is not possible due to lack of in vivo mutagenicity test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, Ames tests gave negative results (NTP DB (accessed in October 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a study in which developmental toxicity of the substance on the offspring was addressed, but details such as animal species used and test results were not well explained (GESTIS (accessed in October 2008)). Thus, classification is not possible due to insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In 4-hour inhalation exposure tests using rats, neurological symptoms such as staggering, tremor, and atonia were detected at 26 mg/L which falls under the "Not classified" category guidance values (GESTIS (accessed in October 2008)). Similarly, in 8-hour inhalation exposure tests using rats, neurological symptoms such as staggering, tremor, and atonia were detected at 6.5 mg/L which falls under Category 1 guidance values (GESTIS (accessed in October 2008)). Based on these results, the substance was classified into Category 1 (central nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system)	Danger	H372	P260 P264 P270 P314 P501	In 2-week inhalation exposure tests using rats (6 hours/day and 5 days/week), central nervous disturbances and squamous metaplasia with necrosis and desquamation of the nasal mucous membranes were noted at 18.4 mg/L, which is above the guidance doses. In 12-month inhalation exposure tests using rats (5 hours/day and 5 days/week), an increased disturbance of the motor system and reduced activity of the acetylcholineesterase in blood serum were detected at 0.05 mg/L or higher doses, which fall under Category 1 guidance doses (GESTIS (accessed in October 2008)). Based on these results, the substance was classified into Category 1 (central nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Since its 96-hour LC50 is 5950 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is water soluble (water solubility: 175000 mg/L (SRC, 2005)) and its classification for acute toxicity is "Not classified", the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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