NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	110-93-0
Chemical Name	6-Methyl-5-hepten-2-one
Substance ID	m-nite-110-93-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported 56 degC (closed-cup) (IUCLID (2000)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its auto ignition point is >= 250 degC (IUCLID (2000)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded only to carbon.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the rat LD50 values of 3570 mg/kg bw and 4100 mg/kg bw (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 value of > 5000 mg/kg bw (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on the rat LC50 value of > 13.96 mg/L/4hrs (converted value from > 6.98 mg/L/8hrs) (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified". The test concentration (6.98 mg/L) was higher than the saturated vapor pressure concentration (5.18 mg/L), the criterion values for dust/mist were adopted for the classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "slightly irritating" (SIDS (Access on Jun. 2010)) resulted from the rabbit test in which application of the undiluted substance for 20 hours caused only erythema and symptoms were all reversible in 48 hours.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In the rabbit test, scores of the Draize at 24 hours after the application were 1 for corneal opacity, 1 for conjunctival redness, 0 for chemosis, respectively. All signs of irritation were completely reversible within 8 days (SIDS (Access on Jun. 2010)). Based on the document, the substance was classified as Category 2B.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	No sensitization was reported in the modified Draize test using guinea pig, open epicutaneous test, and human maximization test, and concluded that the substance is not a sensitizer (SIDS(Access on Jun. 2010)). Based on the information, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	The classification was concluded as "Not classified" based on the negative results in the micronucleus test (in vivo mutagenicity test in somatic cells) using bone marrow cells by intraperitoneal administration to mice (SIDS (Access on Jun. 2010)). As relevant information, as for in vitro study, negative results in the Ames test were reported (SIDS (Access on Jun. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the developmental toxicity study by oral administration using pregnant rat during the organogenetic period, maternal general toxicity occurred at the highest dose level (1000 mg/kg/day), but no effects were observed in gestational and developmental parameters and findings of teratogenicity up to and including 1000 mg/kg/day (SIDS (Access on Jun. 2010)). In the 13-week repeated dose oral toxicity study in rats, the test compound caused testicular toxicity affecting spermatogenesis at the high dose level of 1,000 mg/kg bw/day (SIDS (Access on Jun. 2010)). Despite these results, the substance was classified as "Classification not possible", due to insufficient data regarding the effects on sexual functions and fertility in parental animals.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In the rats administered orally at 1360 mg/kg bw or higher, the clinical symptoms containing apathy, atonia, dyspnea, abdominal and lateral position were noted with dose-dependent intensity. Recovery occurred in survivors within 5 days at the dose level of 4650 mg/kg bw or lower, and no abnormalities were detected at necropsy (SIDS (Access on Jun. 2010)). Another signs observed in rats administered orally in another study with the doses between 2000 and 5000 mg/kg/bw were immediate agitation followed by ataxia (SIDS (Access on Jun. 2010)). Furthermore, it was reported that dysequilibrium was noted immediately after exposure by inhalation with higher concentrations, but recovered one day after exposure (SIDS (Access on Jun. 2010)). Since the above symptoms occurred at higher doses and recovered relatively soon, the substance was classified as Category 3 (narcotic effects).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In the 3-month oral toxicity study with rats (OECD TG 408, GLP-compliant), it was reported that the effects were seen in all dose levels (50-1000 mg/kg/day), and the target organs were kidneys, liver and testes (SIDS (Access on Jun. 2010)). The effects on kidneys were induced for males in all dose groups by accumulation of alpha-2-microglobulin which was known to be a rat-specific phenomenon without a toxicological relevance in humans. As for the liver, increased liver weights associated with centrilobular hypertrophy of hepatocytes were observed in high dose (1000 mg/kg/day), and as for the effects on the testis a testicular atrophy was also observed in high dose group (1000 mg/kg/day), but these were not found in the control and any other treatment groups. As stated above, the effects on the liver and testis were not observed at the doses below the mid dose (200 mg/kg/day), and the mid dose was over the upper limit of the guidance values. While, the findings of the kidney were male-rat-specific, and not relevant to humans. Thus, "Not classified" was applicable for oral route, but as the effects in the other routes (inhalation, dermal) were unknown due to lack of sufficient data. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 96h-LC50 = 68 mg/L for fish (Leuciscus idus) (SIDS, 2005).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified as "Not classified" since it is rapidly degradable (BOD degradation rate tested by OECD TG301F: 91% (SIDS, 2005)) and its bioaccumulation potential is estimated to be low (Log Kow = 2.4 (SIDS, 2005)) though its acute toxicity is Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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