NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	111-88-6
Chemical Name	Octane-1-thiol; n-Octyl mercaptan
Substance ID	m-nite-111-88-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point reported 68 degC (closed-cup) (GESTIS (Access on August 2010)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 240 degC (GESTIS (Access on August 2010)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no fluorine, chlorine or oxygen.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the data which were chosen from the various LD50 values for rats documented in the "List 1"information source designated in the GHS classification guidance for the Japanese government, namely, 2000 mg/kg (male) and 1293 mg/kg bw (female) in the test which was conducted in accordance with OECD test guideline and was reported in the valid information source ("Toxicity Testing reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)), the substance was classified as Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	The rat LD50 value of > 2000 mg/kg bw (PATTY, 5th (2000)) and the rabbit LD50 value of 1686 mg/kg bw (PATTY, 5th (2000)) were reported. Based on the rabbit data as selecting the category of greater hazard, the substance was classified as Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It was reported that exposure of 508 ppm/4hrs (3.04 mg/L/4hrs) to rats caused no mortality and the LDLo was > 5.08 mg/L/4hrs (PATTY, 5th (2001)). Since the value did not provide the basis for the classification, the classification was not possible. Because the test concentration was between the saturated vapor pressure concentration and 90% of it, the test substance was estimated as "vapor mixed with mists" and the criterion values for vapor were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented case of "slight irritant" with the irritation index of 0.3 resulted from the rabbit test (PATTY, 5th (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	The substance was classified as Category 2 based on the documented case of "moderate or slight irritation" resulted from the rabbit test (PATTY, 5th (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	In the guinea pig test, moderate skin sensitization was reported (PATTY, 5th (2001)). However, details on test methods and positive rate were lacking, and thus, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and in the chromosome aberration test using CHL cells were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), as the influence on reproductive function of parental animals, extension of average days of the estrous cycle and low delivery index was observed in females of the 250 mg/kg group. However, no treatment related changes in the indices of sexual functions and fertility of parental animals, and in the development and viability of offspring ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). In addition, about slight extension of estrous cycle, the possibility of the secondary change according to the deterioration of the general status of maternal animals by repeated dose was considered to be the cause. Moreover, the delivery index of 85.85% at 250 mg/kg group was slightly lower than the lower bound (86.74%) of the historical data, and thus, it was guessed to be slight as the influence on reproductive function for maternal animals ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). From the above-mentioned, neither was assumed to be the basis for classification. Therefore, this substance did not induce effects on sexual functions and fertility. However, the effects on development of offspring containing teratogenicity was unknown due to no information available. Therefore, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In the acute oral toxicity study in rats, deaths occurred at 1000 mg/kg or more, and clinical signs of toxicity such as decrease in locomotor activity, ataxic or abnormal gait, lateral or ventral position, crouching position, lacrimation or chromodacryorrhea, etc. at 1000 mg/kg or higher, and anemia-like symptoms, hypothermia, tremors, hyperirritability and salivation at 2000 mg/kg were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). In addition to these signs, the substance influenced on central nervous system, and it was described that exposure at high levels may result in lowering of consciousness (HSDB (2006)). Thus, the substance was classified as Category 2 (central nervous system). Furthermore, in another acute oral study in rats (LD50 value: 2000 - 2445 mg/kg), clinical signs of lethargy and narcosis were described (PATTY, 5th (2001)). Category 3 (narcotic effects) were, thereby, added. In addition, digestive tract injuries such as erosions and ulcers of the forestomach were reported. However, these findings were excluded from the basis for classification since it was described that those were considered as changes indicating irritating effects on mucous membrane ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (hematopoietic system)	Warning	H373	P260 P314 P501	In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422), the principal findings observed at 250 mg/kg/day (converted dose level as that of 90-day study: 97.2 - 117 mg/kg/day) were as follows: decrease in locomotor activity, abnormal gait, suppression of body weight gain in systemic general conditions, low values of erythrocyte count and hemoglobin concentration in hematology, high values of GPT and total bilirubin and low value of triglyceride in clinical chemistry, dark reddish discoloration and enlargement of the spleen, and thickening of forestomach wall in necropsy. Histopathologically, treatment-related changes were observed in the spleen and femoral bone marrow at 250 mg/kg/day, and in the stomach at 50 mg/kg/day or higher. The former included increased erythropoiesis and hemosiderin deposition. The latter consisted of hyperplasia, hyperkeratosis, submucosal edema or inflammatory cellular infiltrations in the squamous epithelium of the forestomach which was attributed to irritability of the test article ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). As stated above, the effects on blood system, spleen and bone marrow appeared, and enhancement of erythropoiesis and increased hemosiderin deposition were noted in the doses equivalent to Category 2 (97.2 - 117 mg/kg/day) of the guidance values ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). Consequently, the substance was classified as Category 2 (hematopoietic system). Besides, the changes in the forestomach observed at 50 mg/kg/day (converted dose level as that of 90-day study: 19.4 - 23.3 mg/kg/day) or more were excluded from the basis for classification because of the judgment as an irritating effect by repeated oral administration with the substance ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 72h-EC50 = 0.014 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and there are no adequate data on rapid degradation.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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