NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1118-46-3
Chemical Name	Butyltrichlorotin
Substance ID	m-nite-1118-46-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It was classified in Category 4 based on a flash point of 81 deg C (closed-cup) (HSDB (Access on July 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 560 deg C (GESTIS (Access on July 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because the result of being soluble in water (GESTIS (Access on July 2014)) was obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen), and the chlorine is chemically bonded to the element other than carbon or hydrogen (Sn). However, the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values for rats of 2,140 mg/kg (EHC 15 (1980)) and > 2,000 mg/kg (male and female) (SIDS (2009)), it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on a report that severe erythema, mild edema and severe tissue destruction were observed after applying 0.5 mL of an undiluted liquid of this substance to rabbits (SIDS (2009)), it was classified in Category 1. Based on the information in List 1, the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are no data on eye irritation of this substance. However, because this substance is recognized to be corrosive in the skin irritation test and classified in Category 1, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2009)) and as for in vitro, bacterial reverse mutation tests showed negative or positive results, and a gene mutation test and a chromosomal aberration test with cultured mammalian cells showed negative results (SIDS (2009), ATSDR (2005), CICAD 73 (2005), NTP DB (Access on September 2014)). Therefore, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	This substance is classified in A4 by ACGIH (7th, 2001) as an organic tin compound. Therefore, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a reproduction toxicity screening test with rats by the oral route (feeding) (OECD TG 421, administered only to females), no effects on maternal general toxicity, fertility and pups were observed at the highest dose (7,500 mg/kg feed (female: 433-685 mg/kg/day)) (SIDS (2009)). In a teratogenicity test with rats by the oral route, neither maternal nor developmental toxicity was observed at the highest dose (400 mg/kg/day) (CICAD 73 (2006)). In a teratogenicity test with rats by the oral route, although lower values of fetus body weight were observed at a dose (1,500 mg/kg/day) where maternal toxicity including death (death in 5/11 animals and decreased body weight) appeared, no external malformation was observed (CICAD 73 (2006), SIDS (2009)). In a teratogenicity test with rats by the oral route, although lower values of female pups' body weight were observed at doses (903 mg/kg/day) where maternal toxicity (decreased body weight gain and decreased food consumption) appeared, no teratogenicity was observed (SIDS (2009)). Though the above results, they are screening tests, so it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	There were reports that in an oral dose of 2,800-4,000 mg/kg to rats, apathy, emphysema, lung lesions, hemorrhagic erosion of the mucosal glands, extensive intestinal and pancreatic bleeding, and necrosis in the liver and kidney were observed, and in an oral dose of 200-6,000 mg/kg to mice, periodic respiration was shown and dilatation of the stomach, blood stains in the stomach contents, hemorrhages in the mucous membrane of the gastrointestinal tract, hyperemic intestinal wall and serosa, darkened and enlarged liver and spleen, and light red and slightly darkened kidney were macroscopically observed (SIDS (2009), EHC 15 (1980), HSDB (Access on July 2014)). In addition, there is a report that this substance shows no hepatotoxicity (ATSDR (2005)). It is described that it may be irritating to the respiratory tract as an organic tin compound (ATSDR (2005), ACGIH 7th (2001)). From the above, there was no information on this substance in humans, and the experimental animals' results were not treated as the target of categorization as in the previous classification and were not treated as the target of classification except for respiratory tract irritation. Therefore, it was classified in Category 3 (respiratory tract irritation).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There are no hazard findings on this substance on repeated exposure for humans. As for experimental animals, in a test in which rats were dosed by feeding for 13 weeks, no toxic effects were observed at up to the upper limit dose of Category 2 (96 (male) - 101 (female) mg/kg/day), and the effects on the liver (increased weight, increased enzyme activity derived in bile acid in blood) and the hemal system (increases in reticulocyte ratio, the number of white blood cells, lymphocyte ratio, decreased MCH) were observed at the high dose corresponding to "Not classified" (SIDS (2009)). On the other hand, as for the inhalation route, in a test in which rats were exposed to the substance (average particle size: 0.98-1.7 micrometer (assumed to be the mist)) by nose-only inhalation for 4 weeks, the effects on the lung due to irritation were severe, lung discoloration, histological alveolar edema, peribronchial lymphoid cell accumulation, and accumulation of alveolar macrophages were observed at from the extremely low concentration (2.4 mg/m3 (converted guidance value: 0.00074 mg/L/6 hours)) within the range of Category 1. The effects became severe depending on the concentration, and the death case appeared at the concentration (71.3 mg/m3 (converted guidance value: 0.022 mg/L/6 hours)) slightly higher than Category 1. However, no findings to enable identification of the target organ other than the respiratory organs were obtained (SIDS (2009)). From the above, it was classified in Category 1 (respiratory organs).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour ErC50 = 0.31 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2009).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2009)), and 72-hour ErC10 = 0.012 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2009). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2009)), and 48-hour EC50 = 25 mg/L for crustacea (Daphnia magna) (CICADs 73, 2006). By drawing a comparison between the above results, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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