NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	112-75-4
Chemical Name	N,N-Dimethyltetradecan-1-ylamine
Substance ID	m-nite-112-75-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Flammable liquids	Not classified	- -	-	-	A flash point was 151 deg C (closed-cup) (GESTIS (Accessed June 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 235 deg C (ECHA (Accessed June 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
13	Oxidizing liquids	Classification not possible	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] From (1) - (3), the category with higher hazard was adopted, and it was classified in Category 4. [Evidence Data] (1) LD50 for rats (females) (OECD TG401, GLP): 1,320 mg/kg (REACH registration dossier (Accessed June 2020)) (2) LD50 for rats (males) (OECD TG401, GLP): > 1,600 mg/kg (REACH registration dossier (Accessed June 2020)) (3) LD50 for rats (OECD TG401, GLP): 2,116 mg/kg (REACH registration dossier (Accessed June 2020))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (NICNAS IMAP (2017))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] It was classified in Category 2 from (1) - (4). Besides, irreversible effects on the skin surrounding the eye were observed in eye irritation tests in (3) (4), but by judging comprehensively, including data in skin irritation tests in (1) (2), it was classified in Category 2. [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 14-day observation), skin irritation was seen (erythema/eschar score: 2.7/3/2.7, edema score: 1.7/1.3/1.3) (REACH registration dossier (Accessed June 2020)). (2) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 16-day observation), skin irritation was found (erythema/eschar score: 1.7/1/1.3, edema score: 2.3/2/2) (REACH registration dossier (Accessed June 2020)). (3) It is reported that in an eye irritation test with a rabbit (n = 1) (OECD TG 405, GLP, 14-day observation), the conjunctiva showed swelling up to 72 hours, with half-closed or more than half-closed lids, and hyperemia up to a diffuse crimson discoloration. Eye irritation effects completely disappeared within 14 days. Eschar formation was observed on the skin around the eye at 72 hours or later, with 2 cm of the surrounding area, accompanied by a hardening of the skin and total hair loss after 7-14 days. After detaching of eschar, the skin showed a coarsely porous appearance, and the hair roots seemed to be irreversibly damaged. Due to the severe effects on the skin surrounding the eye, these results were interpreted as irreversible damage (corneal opacity score: 0, iritis score: 0, conjunctival redness score: 1.7, chemosis score: 3.7) (REACH registration dossier (Accessed June 2020)). (4) It is reported that in an eye irritation test with rabbits (n = 3) (OECD TG 405, GLP, 22-day observation), skin damage around the eye (hair loss, exfoliation/sloughing) was seen, and conjunctival redness and skin damage around the eye were not fully reversible within 22 days (corneal opacity score: 0/0/0.3, iritis score: 0/1/1, conjunctival redness score: 0.3/1/3, chemosis score: 1.3/0.7/3) (REACH registration dossier (Accessed June 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 3) (OECD TG 405, GLP, 22-day observation), skin damage around the eye (hair loss, exfoliation/sloughing) was seen, and conjunctival redness and skin damage around the eye were not fully reversible within 22 days (corneal opacity score: 0/0/0.3, iritis score: 0/1/1, conjunctival redness score: 0.3/1/3, chemosis score: 1.3/0.7/3) (REACH registration dossier (Accessed June 2020)). [Reference Data, etc.] (2) It is reported that in an eye irritation test with a rabbit (n = 1) (OECD TG 405, GLP, 14-day observation), the conjunctiva showed swelling up to 72 hours, with half-closed or more than half-closed lids, and hyperemia up to a diffuse crimson discoloration. Eye irritation effects completely disappeared within 14 days. Eschar formation was observed on the skin around the eye at 72 hours or later, with 2 cm of the surrounding area, accompanied by a hardening of the skin and total hair loss after 7-14 days. After detaching of eschar, the skin showed a coarsely porous appearance, and the hair roots seemed to be irreversibly damaged. Due to the severe effects on the skin surrounding the eye, these results were interpreted as irreversible damage (corneal opacity score: 0, iritis score: 0, conjunctival redness score: 1.7, chemosis score: 3.7) (REACH registration dossier (Accessed June 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) In a bacterial reverse mutation test, negative results were reported (REACH registration dossier (Accessed May 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Category 2 (systemic)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	[Rationale for the Classification] Based on (1) to (2), no target organ could be identified from the signs in the oral route. Therefore, it was classified as Category 2 (systemic toxicity). [Evidence Data] (1) It was reported that in an acute oral toxicity test (OECD TG401, GLP) with rats, at 1,250 to 1,600 mg/kg (within the range for Category 2), reduced spontaneous activity, ruffled fur, crouched posture, irregular breathing, reduced respiratory frequency, uncoordinated gait, bloody crusted eye lids and diarrhea were observed (REACH registration dossier (Accessed June 2020)). (2) It was reported that in an acute oral toxicity test (OECD TG401, GLP) with rats, at 2000 mg/kg (within the range for Category 2), 2/5 male rats and 2/5 female rats died, in which ante mortem signs such as underactivity, staggering gait, hyperpnea, piloerection, ungroomed appearance, pigmented staining of the snout, pigmented orbital secretion and hunched posture were observed, and in surviving animals, similar signs were observed with the addition of hair loss (REACH registration dossier (Accessed June 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.18 mg/L for fish (Oncorhynchus mykiss) (REACH registration dossier, 2021).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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