NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	114369-43-6
Chemical Name	4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
Substance ID	m-nite-114369-43-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Classification not possible	- -	-	-	It contains chlorine atoms. No additional information available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Its rat LD50 values were documented from 3 studies (> 2000, > 2000, and > 5000 mg/kg) (JMPR (1997)), and all these values fall under the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its LD50 value of > 2000 mg/kg (JMPR (1997)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Based on its LC50 of > 2.1 mg/L documented (JMPR (1997)), the class cannot be specified between Category 3 and 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on the results that no erythema or edema was noted in the rabbit tests (JMPR (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Based on the results that no effects of the substance were detected in the rabbit tests (JMPR (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	Buehler tests using guinea pigs found that the substance showed no potential for skin sensitization (JMPR (1997)). In maximization tests using guinea pigs, the use of acetone solution resulted in a 10 % positive reaction rate (negative control: 40%), and the use of diethyl phthalate resulted in a 16% positive reaction rate (negative control: 10%), indicating that the substance has weak sensitizing potential (JMPR (1997)). In maximization tests using guinea pigs, the use of either acetone or ethanol resulted in a 0% positive reaction rate, or negative (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2007)). Based on these three sets of results, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	The classification is based on negative results found in vivo mutagenicity tests using somatic cells (micronucleus tests using mouse bone marrow cells) (JMPR (1997)). In addition negative results have been also documented in in vitro tests including Ames tests and chromosomal aberration tests (JMPR (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	In 78-week mixed diet administration tests using mice, higher incidences of hepatocellular adenomas and carcinomas were detected in the highest dose groups compared with control groups. In 2-year mixed diet tests using rats, increased incidences of focal cystic thyroid hyperplasia (12/70 vs. 1/70 in controls), thyroid follicular adenoma, and carcinoma (6/70 vs. 4/70 in controls) were noted in the highest dose groups. Furthermore, in 2-year mixed diet tests using male rats, which was conducted for verification, slight thyroid follicular cell hypertrophy was noted in the highest dose groups, and the dose-response relationship for thyroid follicular adenoma was seen in 2/60, 5/60, and 9/60 rats at the doses of 0, 800, and 1600 mg/kg/day, respectively. Among these positive cases, only two cases of carcinomas were found at 0 and 1600 mg/kg/day groups (all studies cited in JMPR (1997)). Since increased hepatocellular adenomas and carcinomas in mice, and increased thyroid follicular adenoma in rats were reported, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In two-generation mixed diet administration tests using rats, effects of administration on the liver, thyroid gland, and adrenal gland were seen in parental animals, but no reproductive toxicity was detected. In forced oral administration tests conducted during the organogenetic period using pregnant rats, increased early, late, and total resorptions were seen in the highest dose groups, with a corresponding reduction in the average number of fetuses per litter and average fetal weight. In addition, in forced oral administration tests conducted during the organogenetic period using pregnant rabbits, frequent resorptions and abortions were observed in the highest dose groups (both studies cited in JMPR (1997)). Based on these reports, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	In 3-month mixed diet administration tests using mice, hepatocellular hypertrophy and single-cell necrosis in the liver were noted in mouse groups treated within Category 2 guidance doses (33-54 mg/kg). Above these concentrations, hepatocellular hypertrophy, hepatocellular vacuolation, and single-cell or focal necrosis were noted. In 3-month mixed diet administration tests using rats, the following were observed in dose groups (16-104 mg/kg) corresponding to Category 2 guidance values: hepatocellular hypertrophy, centrilobular midzonal vacuolization, mid-zonal and periportal or perilobular vacuolation, centrilobular necrosis, and thyroid follicular epithelial hyperplasia (there is a description that thyroid gland disorder is a secondary effect of liver disorder). In 1-year mixed diet administration tests using dogs, Hepatocytic hypertrophy, and minimal-to-slight multifocal vacuolation were detected in dose groups (14-56 mg/kg) corresponding to Category 2 guidance values (all studies cited in JMPR (1997)). Based on these reports, the substance was classified into Category 2 (liver).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 96-hour LC50 = 0.633 mg/L for crustaceans (Mysidopsis bahia) (AQUIRE, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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