NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	115-90-2
Chemical Name	Phosphorothioic acid O,O-diethyl O-(4-methylsulfinylphenyl) (fensulfothion)
Substance ID	m-nite-115-90-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility of 0.15 g/100 mL (25 deg C) (ICSC (2001)) were obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 1	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	There are multiple LD50 values for rats, 10.5 mg/kg (male) (ACGIH (7th, 2005)), 1.8-2.3 mg/kg (female), 3.96-10.5 mg/kg (male) (JMPR (1972)), 1.8-10.2 mg/kg (PATTY (5th, 2001)) and 3.5 mg/kg (PIM G001 (1998)). According to the GHS Classification Guidance for the Japanese government, it was classified in Category 1 to which most of the reports correspond.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Based on the reports of LD50 values of 3.5 mg/kg (female), 4.1 mg/kg (female), 19 mg/kg (male), 30.0 mg/kg (male) (ACGIH (7th, 2005)), 3.5-13 mg/kg (female), 14-30 mg/kg (male) (JMPR (1972)) for rats, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the reports of LC50 (4 hours) values of 0.0295 mg/L (ACGIH (7th, 2005), PATTY (5th, 2001)) and 0.030 mg/L (JMPR (1972)) for rats, it was classified in Category 1. Besides, since LC50 values were higher than the saturated vapor concentration (0.000832 mg/L), the reference value of the mist was applied.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there is a description that in humans this substance may show skin irritation in contact with skins (HSDB (Access on July 2014)), because it is a general description, it was not adopted for classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there is a description that organophosphorus pesticides cause chronic conjunctivitis and keratitis in contact with the eyes (HSDB (Access on July 2014)), because it is a general description, it was judged to be insufficient data for classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test (JMPR (1982), HSDB (Access on August 2014)). As for in vitro, it was negative in a bacterial reverse mutation test and a sister chromatid exchange test with cultured mammalian cells (JMPR (1982), ACGIH (7th, 2005), HSDB (Access on August 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it is classified as A4 by ACGIH (ACGIH (7th, 2005)), it was classified as "Classification not possible." The classification was revised due to the change in the GHS classification guidance for the Japanese government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	It is reported that there were no effects on fertility of the parents and on development and growth of pups in a three-generation reproductive toxicity study by feeding with mice, that there were no teratogenicity in the teratogenicity studies by oral administration (feeding or gavage) with rabbits, and that no effects on fertility were observed in a reproductive toxicity study by inhalation with rats (ACGIH (7th, 2005), JMPR (1972) JMPR (1982)). Therefore, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance has a cholinesterase inhibiting effect (ACGIH (7th, 2005), HSDB (Access on August 2014)). In humans, it is reported that bradycardia, hypotension, seizures, convulsion, respiratory insufficiency, weakness, coma were seen in oral or dermal exposure, and though the route of exposure was not described, nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, convulsions, disorientation, miosis, weakness, paralysis, coma, dyspnea, rale, bronchorrhea, bronchospasm, tachypnea, respiratory insufficiency, chemical pneumonitis, and as a severe case, non-cardiogenic pulmonary edema are observed (ACGIH (7th, 2005), HSDB (Access on August 2014)). In experimental animals, oral administration of 550 mg/kg to rats caused loss of righting ability (ACGIH (7th, 2005)). From the above, since effects on the nervous system and respiratory organs are seen in humans, it was classified in Category 1 (nervous system, respiratory organs).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	There are no hazard findings in humans. In experimental animals, in each study in which the substance was administered by feeding to rats for 17 months and to dogs for 12 weeks or 2 years, serum, red blood cell, and brain cholinesterase activities were inhibited from concentrations of 1-2 ppm (corresponding to 0.025-0.05 mg/kg/day) in feed, and at the higher dose (5 ppm), cholinergic poisoning symptoms (although there is no specific description, it is speculated that miosis, tremor, convulsions, etc. were observed), weight loss and mortality occurred (JMPR (1972), ACGIH (7th, 2005)). In addition, in a study in which rats were exposed to this substance (presumed to be the mist) by inhalation for 12 weeks, inhibition of cholinesterase at 0.818 mg/m3 (0.00076 mg/L/6 hours), and poisoning symptoms, weight loss and mortality at 7.21 mg/m3 (0.0067 mg/L/6 hours) occurred (JMPR (1982), ACGIH (7th, 2005)). From the above, in experimental animals through both the oral and inhalation routes, neurotoxicity due to cholinesterase inhibition occurred from doses within the range of Category 1, and in severe cases, death was shown. Therefore, it was classified in Category 1 (nervous system).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour TLm=0.12mg/L of fishes (Bluegill) (PDS, 1980).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.23(PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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