Item | Information |
---|---|
CAS RN | 119-64-2 |
Chemical Name | 1,2,3,4-tetrahydronaphthalene |
Substance ID | m-nite-119-64-2_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Its flash point is 82degC (Merck (14th, 2006), HSDB (2003)), which is above 60degC and below 93degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Its autoignition point is 385degC (HSDB (2003), ICSC (2004), NFPA (13th, 2006)), which is above 70degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance does not contain oxygen, fluorine or chlorine. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Its rat LD50 is 2860 mg/kg bw (SIDS (accessed in August 2008)), which is equivalent to the guidance value of Not classified in JIS classification criteria (equivalent to Category 5 in UN classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Since its rabbit LD50 is ca. 16800 mg/kg bw (SIDS (accessed in August 2008)) or 17300 mg/kg bw (PATTY (5th, 2001)) and its rat LDLo is above 7300 mg/kg bw (PATTY (5th, 2001)), the substance was classified into "Not classified". |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Its guinea pig LC50 measured with vapour being 275 ppm (8h-exposure) (4h-conversion, 389 ppm, 2.10 mg/L) (PATTY (2000)) is equivalent to the guidance value of Category 2. As relevant information, since the saturated vapour concentration is 488 ppm, the test was considered to be performed with vapour with almost no included mists (evaluation with gas evaluated values). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As relevant information, it is reported that its rat LCLo measured with mist is above 1.3 mg/L (4h-conversion, 2.6 mg/L) (quivalent to Category 4 or "Not classified") (PATTY (5th, 2001)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In a four-hour skin irritation study according to OECD TG 404 using rabbits, the substance caused moderate irritation with Draize scores of 3.11 for erythema and 1.56 for edema, and the effects were not completely reversible within 14 days (SIDS (accessed in August 2008)). In addition, since its EU Risk Phrase is R36/38, which indicates that its hazard potential is equivalent to Category 2, the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | In a Draize study with rabbits according to OECD TG 405, the substance caused no significant irritation, with a Draize mean score of 5.17/110, and the effects were completely reversible within six days. Also, in another study using rabbits, 0.5 mL of the substance was applied, and the substance caused slight irritation but no damage, with a Draize score of 1/10 (SIDS (accessed in August 2008)). Therefore, the substance was classified into "Not classified". As relevant information, SIDS concluded that animal tests showed no irritation, but high exposure from the gas phase may cause irritation and profuse lacrimation in humans. PATTY and HSDB also documented that the substance is irritating to humans, but they do not report any symptoms caused by the substance (based on expert judgment). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Not classified |
- |
- | - | It is documented that in a guinea pig maximization test according to OECD TG 406, the substance was not sensitizing (SIDS (accessed in August 2008)). Therefore, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since the substance was negative in a micronucleus test by gavage using mice (SIDS (accessed in August 2008), IUCLID (2000)), and negative in a micronucleus test by inhalation using mice (six-hours/day, 13-weeks) (SIDS (accessed in August 2008)) (both were in vivo mutagenicity tests using somatic cells), the substance was classified into "Not classified". As additional background information, regarding in-vitro mutagenicity tests, Ames tests gave negative results while mouse lymphoma tests yielded both positive and negative results, making the mutagenicity evaluation of the substance inconclusive (SIDS (accessed in August 2008)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | The substance did not show any effects on fetuses in a developmental toxicity test using rats performed in accordance with OECD TG 414 (SIDS (accessed in August 2008)). In a mouse inhalation test for 13-weeks (six-hours/day, five-days/week), uretus atrophy and atrophy of the ovary were found (SIDS (accessed in August 2008)). However, since there is no available test data on sexual functions and fertility, and due to the lack of data, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In a rat oral administration test, at the doses of 2000 mg/kg or more, the rats exhibited symptoms of sluggishness, prostration, and narcosis (SIDS (accessed in August 2008)), and in humans, signs such as headache and stupor have been reported (SIDS (accessed in August 2008)). Therefore, the substance was classified into Category 3 (narcotic effects). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood) |
Warning |
H373 | P260 P314 P501 |
In a 28-day toxicity study in rats with gavage, at the dose of 150 mg/kg/day, hemolytic anemia was seen, which was present at two weeks after the end of the administration period, and as the secondary reactions, increased reticulocyte counts and enhanced extramedullary hematopoesis in the spleen have been reported (SIDS (accessed in August 2008)). While, in a 13-week inhalation test in rats or mice, mainly at the doses of 0.333 mg/L and 0.666 mg/L, changes of blood indexes, including regenerative anemia or reduced erythrocyte count, were reported (SIDS (accessed in August 2008)). Based on the above results, since the developmental doses of hemolytic anemia and related signs, that is, 150 mg/kg/day In the 28-day toxicity study with gavage (90-day conversion, 46.7 mg/kg/day) and 0.333 mg/L and 0.666 mg/L in the 13-week inhalation test are within the guidance values of Category 2, the substance was classified into Category 2 (blood). As relevant information, the toxicological meanings of other changes seen mainly in high-dose groups are unknown. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
Since its 96h-LC50 = 3.2 mg/L (SIDS, 2008) for fish (zebra fish), the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Although its preexisting classification for acute toxicity is Category 2, it is rapidly biodegradable (BOD degradability, 81% (SIDS, 2006)) and it is estimated to have low bioaccumulation potency (log Kow = 3.78 (SIDS, 2006)), and therefore, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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