Item | Information |
---|---|
CAS RN | 120-36-5 |
Chemical Name | dichlorprop (ISO); 2-(2,4-dichlorophenoxy) propionic acid |
Substance ID | m-nite-120-36-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon and hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Its rat LD50 values documented are 825-1470 mg/kg (IUCLID (2000)), 800 mg/kg (IUCLID (2000)), and 344 mg/kg (HSDB (2008)). All values fall under Category 4. As additional background information, since only the (+) form has physiological activities as herbicides, data on a (+)/(-) racemic mixture are scarce. Thus, when data on a racemic mixture were not available, evaluations were carried out using the (+) form data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Its rat LD50 of > 4000 mg/kg falls under the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Its rat LC50 is reported to be > 0.65 mg/L/4h (HSDB (2008)). Classification is not possible based only on this value. Given that its saturated vapour pressure is 0.2 mg/L, the study was presumably conducted in a dust state. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
A Draize test using rabbits found the substance irritating (IUCLID (2000)), and another Draize test using rabbits that received a racemic mixture found the substance to be a mild to moderate irritant (HSDB (2008)). In addition to these results, since the substance is rated as R38 in the EU classification, it was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
A Draize test using rabbits found the substance irritating (IUCLID (2000)), and a rabbit test using a racemic mixture found the substance to be a severe to corrosive irritant (HSDB (2008)). In addition to these results, since the substance is rated as R41 in the EU classification, it was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Both a guinea pig maximization test and a test using a racemic mixture found the substance not a sensitizer (IUCLID (2000), HSDB (2008)). These negative results indicate that the substance falls under the "Not classified" category. However, since these are List 2 studies, it was classified into the "Classification not possible" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | In sister chromatid exchange assays using Chinese hamsters that received oral administration of a racemic mixture (in vivo genotoxicity tests), positive results were found at toxic doses only, and its genotoxic effect at sub-toxic dose levels could not be determined (HSDB (2008)). Regarding in vitro tests, Ames tests, chromosomal aberration tests using CHL cells, and mutation tests using V79 cells all yielded negative results (HSDB (2008)). No in vivo test results using a macemic mixture are available. However, since chromosomal aberration tests using bone marrow cells of Chinese hamsters that underwent oral administration of the (+) form (in vivo mutagenicity tests using somatic cells) yielded negative results (HSDB (2008)), the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
Since the substance is rated as Group 2B by the IARC (IARC (1987)), it was classified into Category 2. As additional background information, no increase in incidences of tumorigenesis was noted in either 2-year mixed diet tests using rats, or 18-month mixed diet tests using mice (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
In two-generation reproduction tests using rats (OECD TG 416), no abnormalities were noted in sexual functions and fertility of parental animals or in the offspring (IUCLID (2000)). In oral administration tests conducted during the organogenetic period using rats or rabbits, abnormalities were detected in organs and skeletons of the offspring at non-toxic doses to parental animals (IUCLID (2000)). In addition, in developmental toxicity tests using mice, cleft palate was observed (Birth Defects (3rd, 2000)). Though data on a racemic mixture are not available, using the (+) form data, the substance was classified into Category 1B. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
Although it is unconfirmed if this study was conducted using a racemic mixture, rats that received oral administration of 250 mg/kg bw or higher doses showed nervous effects (e.g., hypothermia, decreased number of rearing, increased limb splay, retarded righting response, and decreased grip strength) (HSDB (2008)), indicating that the substance falls under Category 1. However, since this is a List 2 study, the substance was classified into Category 2 (nervous system). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Though this study is not conducted using a racemic mixture, rats that received oral administration for 90 days (doses: 7.2, 36.7, and 193 mg/kg for male; 8.3, 41.4, and 208 mg/kg for female) showed changes in liver weights, biochemical parameters, and hematological parameters at the doses of 193 and 208 mg/kg, which are above Category 2 guidance values; and no effects were seen other than changes in kidney weights at 36.7 and 41.7 mg/kg, which fall under Category 2 guidance doses (HSDB (2008)). In 13-week oral administration tests using rats (doses: 20, 224, and 683 mg/kg for male; 33, 380, and 1043 mg/kg for female), no effects were noted other than changes in eosinophilia in renal tubule cells, liver weights, biochemical parameters, and hematological parameters at the doses of 683 mg/kg and 1043 mg/kg, which are beyond Category guidance doses (HSDB (2008)). In addition, 13-week rat tests found similar changes in the liver and kidney. However, in any of the above studies, toxic effects of the test substance at doses that fall under the range of guidance values are not clear. Thus, the substance was classified into the "Classification not possible" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
Since its 96-hour LC50 = 0.5 mg/L for fish (rainbow trout) (HSDB, 1998), the substance was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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