NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	120-78-5
Chemical Name	Di(benzothiazol-2-yl) disulphide (MBTS)
Substance ID	m-nite-120-78-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, it is described that it is poorly flammable (GESTIS (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 365 deg C (GESTIS (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] As LD50 values for rats, the data of (1)-(7) are reported, and one case corresponds to Category 4 and six cases to "Not classified." Therefore, by adopting a category with the larger number of cases, it was classified as "Not classified." [Evidence Data] (1) LD50 value for rats: 433 mg/kg (BUA Report (1993)) (2) LD50 value for rats: >5,000 mg/kg (BUA Report (1993)) (3) LD50 value for rats: ca. 7,000 mg/kg (BUA Report (1993)) (4) LD50 value for rats: 7,000 mg/kg (BUA Report (1993)) (5) LD50 value for rats: >7,000 mg/kg (BUA Report (1993)) (6) LD50 value for rats: >7,940 mg/kg (BUA Report (1993)) (7) LD50 value for rats: 12,000 mg/kg (BUA Report (1993))	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] As the LD50 value for rabbits, the data from (1) is reported, and it was classified as "Not classified." [Evidence Data] (1) LD50 value for rabbits: > 7,940 mg/kg (BUA Report (1993))	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) There is a report that this substance (solid state) was applied to the skin of 6 subjects for 24 hours but it showed no irritation (BUA 126 (1993)). (2) There is a report that repeated patch test showed no signs of skin irritation (BUA 126 (1993)). (3) It is described that there was no response in 6/6 animals after 24-hour application in a skin irritation test (FHSA method) with rabbits (BUA 126 (1993)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) There is a description that in an eye irritation test (FHSA method) with rabbits, a slight reaction was observed in 6/6 animals 24 hours after application, but this resolved within 48 hours (BUA 126 (1993)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1)-(7), it was classified in Category 1. [Evidence Data] (1) There is a report that when patch tests were performed on 1,698 subjects, 25 subjects showed positive reactions (BUA Report No. 126 (1993)). (2) There is a report that when patch tests were performed on 78 men and 70 women, a positive reaction was shown in 50/78 (64%) men and 33/70 (74%) women (BUA Report No. 126 (1993)). (3) There is a report that when patch tests were performed on 21 patients who developed contact dermatitis by wearing specific shoes, a positive reaction was shown to a 1% preparation of this substance (BUA Report No. 126 (1993)). (4) There is a report that 9 out of 21 patients who developed contact dermatitis to rubber showed positive reactions to this substance (BUA Report No. 126 (1993)). (5) There is a report that one out of 21 patients who developed allergic symptom to rubber or vinyl gloves showed a positive reaction to this substance (BUA Report No. 126 (1993)). (6) There are reports that when a patch test was performed with a 1% solution of this substance on 17 subjects showing sensitization reaction to 2-mercapto benzothiazole (CAS RN: 149-30-4), all the subjects showed positive reaction, but a controlled test on 20 non-allergic subjects was negative (BUA Report No. 126 (1993)). (7) There is a description that a sensitization reaction was observed in a Maximization test with guinea pigs (BUA Report No. 126 (1993), GESTIS (Accessed Jul. 2018)). [Reference Data, etc.] (8) There is a description of a case of a miner who developed contact hypersensitivity by this substance when contained in the lamp cables used in mines (HSDB (2002), BUA Report No. 126 (1993)). (9) This substance was classified as "Skin Sens. 1" in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Although there is no in vivo data, there is a negative result for a similar substance in (1), and as for in vitro, there are negative results in a bacterial reverse mutation test and a mammalian cell chromosomal aberration test. Therefore, it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) There was a negative result in an in-vivo micronucleus test with rats for the similar substance, MBT (2-Mercaptobenzothiazole) (REACH registration dossier (Accessed Sept. 2018)). (2) As for in vitro, bacterial reverse mutation tests and tests with cultured mammalian cells were negative or could not be assessed (GESTIS (Accessed Jul. 2018)). (3) As for in vitro, it was negative in a bacterial reverse mutation test (REACH registration dossier (Accessed Sept. 2018)). (4) As for in vitro, it was negative in a chromosomal aberration test with cultured mammalian cells (REACH registration dossier (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] As for carcinogenicity, there are no available reports on humans. There are no classifications by other organizations as shown in (2), and there is a negative report with experimental animals as shown in (1), but it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) In a carcinogenicity study with 2 strains of mice dosed orally for 18 months, no significantly higher incidence of tumors compared with controls was observed at the highest dose of 1,577 ppm (REACH registration dossier (Accessed Sept. 2018)). (2) There are no classification results by domestic and international organizations. [Reference Data, etc.] (3) There is a report that carcinogenicity was not shown, but the test conditions are unknown (GESTIS (Accessed Jul. 2018)). (4) In a carcinogenicity study with mice in which a similar substance, MBT (2-Mercaptobenzothiazole) was administered by feeding for 2 years, no significant results were obtained compared with the control group considering the historical data, and no clear carcinogenicity could be concluded (REACH registration dossier (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] No developmental toxicity of this substance was observed in (1), and no reproductive or developmental effects were detected for the similar substance, MBT as shown in (2) and (3). In conclusion, although it is considered that this substance does not cause developmental effects, there is no finding on reproductive toxicity. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As developmental toxicity of MBTS to rats, neither fetotoxicity nor teratogenicity effects was observed even at administration of the highest dose of 596 mg/kg/day (REACH registration dossier (Accessed Sept. 2018), GESTIS (Accessed Sept. 2018)). [Reference Data, etc.] (2) No effect on fertility was observed in a two-generation reproductive toxicity study of MBT with rats (GESTIS (Accessed Sept. 2018)). (3) In a developmental toxicity study of MBT with pregnant rabbits, neither developmental toxicity nor teratogenicity was induced in oral administration of 50, 150, and 300 mg/kg/day. In the administration of 300 mg/kg/day, decreased body weight gain and slightly increased liver weight were observed in maternal animals (REACH registration dossier (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on the data in (1), this substance corresponds to "Not classified" through the oral route, but toxicity information from the other routes is inadequate. Therefore, it was classified as "Classification not possible." [Evidence Data] (1) In an acute test in which the dose of 7,940 mg/kg out of the range of Category 2 was administered orally to rats, reduced appetite and activity were observed after 1-3 days, but no changes were observed in organs on necropsy of survival animals after 7 days (REACH registration dossier (Accessed Sept. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on the data in (1)-(3), this substance corresponds to "Not classified" through the oral route. However, since toxicity information of the other routes is inadequate, it was classified as "Classification not possible." [Evidence Data] (1) In a 21-day oral administration study with rats, temporarily decreased body weight gain was observed at the dose of 596 mg/kg/day (converted guidance value: 139 mg/kg/day) (BUA Report No. 126 (1993)). (2) In a 3-month oral administration study with rats, decreases in lactate and malic dehydrogenase activity were observed at the dose of 100 mg/kg/day which is the upper limit value of Category 2. However, there is no description of other toxicological findings (BUA Report No. 126 (1993)). (3) In a 31-day oral administration study with rats, no effects other than decreased body weight gain were observed at the doses of 375, 750, and 1500 mg/kg bw/day (converted guidance value: 125, 250, 500 mg/kg bw/day) out of the range of Category 2 (BUA Report No. 126 (1993)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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