Item | Information |
---|---|
CAS RN | 120-80-9 |
Chemical Name | Catechol; Pyrocatechol |
Substance ID | m-nite-120-80-9_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is combustible (ICSC (J) (1997)), but the classification is not possible due to no data in the prescribed test method. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 510 deg C (HSDB (2009)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
It was classified in Category 3 based on LD50 values for rats of 260 mg/kg (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)) and 300 mg/kg (SIDS (Access on Apr. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Both an LD50 value of 600 mg/kg for rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) and an LD50 value of 800 mg/kg for rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) correspond to Category 3. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There were no deaths after 8-hour exposure of rats to a concentration of 1.5 mg/L (converted 4-hour equivalent value: 3.0 mg/L) (ACGIH (2001)), which means LC0 > 3.0 mg/L/4 hours. However, because the category cannot be determined, the classification is not possible. Besides, because the test concentration (1.5 mg/L) was higher than the saturated vapour pressure concentration (0.13 mg/L), it was regarded as a test on dust. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In a primary skin irritation test (US Federal Register (1961)) by 24-hour occlusive application of 0.5 g of this substance to (six) rabbits, moderate erythema and slight edema were seen in all animals after 24 hours, but the signs were diminished after 72 hours and disappeared after 14 days, and it was assessed as moderate irritation (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 2. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In a primary eye irritation test (US Federal Register (1961)) in which 0.1 g of this substance was applied to six rabbits, moderate erythema and edema in the conjunctiva, secretion of exudate, and corneal opacity were observed immediately after the application, and conjunctival congestion, lid closure, marked secretion of exudate, iritis, and severe corneal opacity were seen after 24 hours. There was no recovery after 48, 72 hours, corneal pannus formation and keratoconus were found in all animals after 14 days, and it was judged as a severe irritant (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Based on the judgment and the fact that corneal pannus formation and keratoconus after 14 days were irreversible signs, it was classified in Category 1. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is reported that an 18-year-old woman who used a permanent hair dye cream developed acute contact dermatitis around the eyes, and after its disappearance, she was patch tested with cream components, using ICDRG (International Contact Dermatitis Research Group) criteria and showed a positive reaction to this substance, which was proven to be a causal substance for allergic contact dermatitis (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Furthermore, it is reported that a 33-year-old woman who had worked as a technician of radiography and photographic development for 10 years developed dermatitis in her hands two years after the start of the work, keratinization of the squamous epithelium with itchiness was observed, and a moderate positive reaction to this substance, which was a component of a developer, was seen in a patch test, using ICDRG criteria (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). From the above, because case reports indicating that this substance caused allergic contact dermatitis came from two different facilities, it was classified in Category 1. Besides, in animal tests, positive results were reported in both two kinds of skin sensitization tests with guinea pigs (Freund's Complete Adjuvant Test and Split Adjuvant Test), although they were not the test methods approved by OECD (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
It was classified in Category 2 based on positive results in micronucleus tests with bone marrow cells after oral or intraperitoneal administration to mice (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). There are reports on negative results in other micronucleus tests by oral or intraperitoneal administration to mice (NTP DB (1994), Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)) and both negative and positive results in genotoxicity tests by oral administration to rats (DNA synthesis, cleavage, and repair tests) (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). On the other hand, as for in vitro tests, it is reported that Ames tests were mostly negative, and a gene mutation test, a chromosomal aberration test, and a micronucleus test with cultured mammalian cells gave positive results (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification Based on (1), which reported that an increase in tumors including malignant ones was consistently observed in several independent studies even though it was with one species of test animals, and the findings of (2) and (3), it was classified in Category 1B. [Evidence Data] (1) It was reported that, in two 2-year oral administration tests with rats dosed by feeding, at 8,000 ppm, a clear increase in the incidence of adenocarcinomas in the glandular stomach was observed in males and females, and several strains (IARC 71 (1999), CLH Report (2015)). (2) In several initiation/promotion experiments in rats involving administration with known carcinogens, this substance enhanced the incidence of papillomas of the tongue, carcinomas of the esophagus, squamous-cell carcinomas of the forestomach, and adenocarcinomas of the glandular stomach (IARC 71 (1999)). (3) As for the classification by domestic and international organizations, the ECHA classified it in Carc. 1B (EU-CLP Classification Results (Accessed Oct. 2021: proposed in 2016). In addition, the IARC classified it in Group 2B (IARC 71 (1999)), the Japan Society For Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2020, proposed in 2001)), the ACGIH classified it in A3 (ACGIH (7th, 2001)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In a test by oral administration to rats on a gestational day 11, maternal animals showed reduced weight gain and a dose-dependent increase in deaths, the number of pups decreased by postnatal day 6, and a ratio of live births having paralyzed hindlimbs, short or kinked tails increased dose-dependently (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 2. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
As information in humans, it is described that short-term exposure to this substance affects the central nervous system, causing depression, convulsions, and respiratory failure (Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). And it is described that effects on the central nervous system (convulsions, etc.) by dermal absorption are severer than those by phenol (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Based on the above knowledge, it was classified in Category 1 (central nervous system). And it is described that short-term exposure to this substance is irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)), and inhalation leads to burning sensation to the throat and lung, followed by marked tachypnea (PATTY (5th, 2001)). Therefore, it was classified in Category 3 (respiratory tract irritation). Besides, in animal tests, it is reported that continuous shiver was observed after inhalation exposure of rats to 2.0 mg/L or above (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)), and in a dermal application test with rats, marked shiver occurred five minutes after the application at or above 875 mg/kg (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Effects observed after 104-week diet administration to rats were hyperplasia of the gastric pyloric gland and cystic enlargement or dilatation of lymph nodes around the stomach at or above 0.1% (33 mg/kg/day), thickening of the gastric pylorus at or above 0.2%, and hyperplasia of the squamous epithelium in the forestomach at or above 0.4% (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). And in a test by 13-week oral administration of 150-300 mg/kg/day to rats and mice, hyperplasia and squamous papillomas in the forestomach were seen (ACGIH (2001)), but there are no reports on adverse effects on organs other than the stomach. Due to its irritating/corrosive property, this substance produced local effects in the digestive system after oral administration, and was carcinogenic to the stomach in rats, and made preneoplastic lesions. Therefore, it was classified as "Classification not possible" for this hazard class by not using the above results. Besides, as information in humans, it is described that 30 workers exposed to this substance and phenol complained of sore throat, cough, and eye irritation, especially many skin disorders, and examination revealed no decreased function in the hematopoietic system, liver, and kidney, and no anomalies in urine test (IUCLID (2000)). And kidney effects were suggested from the description of degenerative lesions in the renal tubules (PATTY (4th, 1999)), but the details are unknown. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 24-hour EC50 = 1.66 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Despite 24-hour EC50 = 1.66 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)), due to being rapidly degradable (readily biodegradable (a 2-week degradation rate by BOD: 83%) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), and a low bioaccumulation estimate (log Kow = 0.88 (PHYSPROP Database, 2009)), it is classified as "Not classified." From the above results, it was classified as "Not classified." |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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