NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	12026-57-2
Chemical Name	Phosphomolybdic acid
Substance ID	m-nite-12026-57-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water due to the observation result of being soluble in water (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data available. However, from the information that phosphomolybdic acid is an acidic substance, forming stable salts with basic dye, which are used for pigments, and reaction products with dye are used for pigments such as crayon and paint (Encyclopedia Chimica (Kyoritsu Shuppan Co., Ltd., 2006)), it is estimated that the substance is not oxidizing.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	There is no information on this substance. 　For sodium molybdate which is a water soluble molybdenum compound, as for in vivo, positive was observed in a micronucleus assay in mouse bone marrow cells, however, the degree of micronucleus induction is small. Additionally, it is reported that in a dominant lethal assay using mice dosed with sodium molybdate, it is positive. However, the authors concluded that a definite conclusion could not be leaded because it was preliminary data from a pilot experiment (Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012), ACGIH (7th, 2003), Titenko-Holland et al. (1998)). 　As for in vitro, it is reported that a bacterial reverse mutation test on soluble molybdenum salts (details unknown) is negative, and chromosome aberration tests, micronucleus tests and sister chromatid exchange assay using mammalian cultured cells on hexaammonium heptamolybdate or sodium molybdate are positive (Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012). 　From the above, based on information on water soluble molybdenum compounds, this substance was classified in Category 2. 　Additionally, in the Environmental Risk Assessment for Chemical Substances (2012) and ACGIH (7th, 2003), it is reported that hexaammonium heptamolybdate is also positive in a micronucleus assay in mouse bone marrow cells and a dominant lethal assay in mice. However, it was confirmed that hexaammonium heptamolybdate was not subject to the study according to the original literature (Titenko-Holland et al. (1998)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There is no information on the carcinogenicity of this substance itself in humans or experimental animals. 　However, based on NTP test data using molybdenum trioxide (CAS RN 1313-27-5), ACGIH deemed that soluble molybdenum compounds is a confirmed animal carcinogen and classified soluble molybdenum compounds as A3 (ACGIH (7th, 2003)). Since this substance also corresponds to soluble molybdenum compounds, it was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is no information on the reproductive effects of this substance itself. 　However, in a test using rats with sodium molybdate dihydrate, a soluble molybdenum compound, reproductive effects are observed. It is reported that a delay of estrous cycle was observed when female rats were dosed by drinking water for 6 weeks (Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012)). 　In addition, a decrease in body weight gain was observed at 20 ppm or higher, and a decrease in conception rates was observed at 80 and 140 ppm when female and male rats were administered by feeding for 13 weeks prior to mating. In the administration group of 80 ppm or higher, only two of eight males provided offspring, and when infertile 6 males were mated with untreated females, no pregnant females were found. It is reported that the cause of infertility was attributed to the males, and degeneration of the seminiferous tubules was found in histopathologic examination of the testes (Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012)). Because this substance is a soluble molybdenum compound and is thought to have adverse effects on sexual function and reproductive potential in animal experiments as sodium molybdate does, it was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that this substance is soluble in water (Environmental Risk Assessment for Chemical Substances Vol. 10 (Ministry of the Environment, 2012)). 　There is no single exposure data in humans and experimental animals. 　Ammonium molybdate (CAS RN 12027-67-7) and sodium molybdate (CAS RN 7631-95-0), both of which are soluble molybdenum compounds, are reported to cause respiratory tract irritation (DFGOT vol. 18 (2002), ACGIH (7th, 2003), Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012)). 　They have been classified in Category 3 (respiratory tract irritation) in the FY 2015 GHS classification by the Ministry of Health, Labour and Welfare and the Ministry of the Environment. 　This substance is also thought to be possible to cause respiratory tract irritation similar to these soluble molybdenum compounds. Therefore, it was classified in Category 3 (respiratory tract irritation).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is described that this substance is soluble in water (Environmental Risk Assessment for Chemical Substances Vol. 10(Ministry of the Environment, 2012)). 　There is no data on this substance in humans and experimental animals. 　Additionally, also for ammonium molybdate (CAS RN 12027-67-7) and sodium molybdate (CAS RN 7631-95-0), both of which are soluble molybdenum compounds, there is no information in humans 　Besides, as for experimental animals, for sodium molybdate, systemic toxicity (death for which the target organ could not be specified, extreme emaciation and weight loss) and effects in the testes were observed at doses corresponding to Category 1, and effects in the kidney at doses corresponding to Category 2 were observed. For ammonium molybdate, effects in the kidney were observed at doses corresponding to Category 2. All the doses for this substance, which were converted from the doses of sodium molybdate or ammonium molybdate with these findings observed, were above the range for Category 2. 　From the above, since there is no information available for the evidence of classification in target organ toxicity of this substance, it was classified as "Classification not possible."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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