NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	121-29-9
Chemical Name	2-methyl-4-oxo-3-(penta-2,4-dienyl)cyclopent-2-enyl[1R-[1alpha[S*(Z)](3beta)]]-3-(3-methoxy-2-methyl-3-oxoprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate; pyrethrin II
Substance ID	m-nite-121-29-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There are chemical groups present in the molecule associated with self-reactive properties. However, since no data are available, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on its LD50 = 1.2 g/kg for rats (HSDB (2005)), the substance was classified into Category 4. Pyrethrin II is an ingredient of Pyrethrum (a mixture of ingredients of Pyrethrin I, Pyrethrin II, Cinerin I, Cinerin II, and Jasmolin).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	The rat LC50 = 3.4 mg/L/4h of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) (HSDB (2005)). However, there is no data on Pyrethrin II itself, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	When 200 people were patch tested with a 1% water dispersion of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II), no evidence of primary irritancy was found (HSDB (2005)). However, there is no data on Pyrethrin II itself, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is documented that in humans, the Pyrethrin mixture consisting of Pyrethrin I and II in pure form may cause transient conjunctival edema and hyperemia and is irritating to eyes and mucous membranes; however, no persistent ocular disturbance from pyrethrum or its derivatives appears to have been reported (HSDB (2005)). The effects are transient and reversible, and therefore, the substance was classified into Category 2B. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	A case has been reported of a 36-year-old woman with a history of asthma who developed severe shortness of breath five minutes after she began to wash her dog with an insecticide shampoo containing 0.05% of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II). She soon developed gasping respiration. In five minutes, she was in cardiopulmonary arrest, and she died (HSDB (2005)). In addition, an asthma-like reaction (hypersensitive pneumonitis) occurred in sensitized patients with exposure to Pyrethrins has been reported (HSDB (2005)). However, its respiratory sensitization has not been concluded to be positive in all cases, and therefore classification is not possible. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	A case in which a patient with a history of allergic dermatitis from pyrethrum showed positive patch-test responses not only to pyrethrum flower heads and extracts but also to Pyrethrin II has been reported (HSDB (2005)). On the other hand, it has been reported that when 200 people were patch tested with a 1% water dispersion of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II), no evidence of sensitization was found (HSDB (2005)). In addition, the sensitizing properties of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) were suggested to be associated with impurities of the test substances (HSDB (2005)). As described above, no certain conclusions on skin sensitization have been established, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Pyrethrum is rated as A4 in the ACGIH classification (HSDB (2005)), which is equivalent to the "Not classified" category in the GHS classificaiton. However, there is no information available to classify Pyrethrin II into "Not classified", and due to the lack of data, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Human clinical manifestations of inhalation exposure to pyrethrum and synthetic pyrethroids including the following have been indicated: in the upper respiratory tract, rhinitis, oral mucosal edema, and laryngeal mucosal edema; in the lower respiratory tract, cough, shortness of breath, and chest pain (HSDB (2005)). And it is described that Pyrethrin II in pure form is irritating to skin, eyes, respiratory tracts, and mucous membranes (HSDB (2005)). Therefore, the substance was classified into Category 3 (respiratory tract irritation). (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	When the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) were fed for two years (the animal species are not shown), liver lesions were reported (HSDB (2005)). However, since Pyrethrin II itself was not used and the obtained data were insufficient, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Based on its 48h-LC50 = 0.017 mg/L for crustaceans (Daphinia magna) (ECOTOX, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its preexisting classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC, BioWin V4.10), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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