NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122-52-1
Chemical Name	Triethyl phosphite
Substance ID	m-nite-122-52-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 3 since flash point 54 degC (closed-cup) (ICSC (1997)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2323).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 250 degC (Hommel (1996), HSDB (2007)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is an organic compound containing metalloids (P) and is quickly hydrolyzed (SIDS (2003)). Further, it is classified into Class 3, PG III in UNRTDG (UN2323). The substance is classified into Not classified since it is not classified into upper Division 4.3 (Substances which in contact with water emit flammable gases) from the Precedence of hazards Table.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified	- -	-	-	Flammable liquid	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	LD50 values are >2385 mg/kg bw (male), 1840 mg/kg bw (female), 2470 mg/kg bw (male) and 4000 mg/kg bw for rats (SIDS (2003)). Since one value corresponds to Category 4 and three values correspond to "Not classified" in JIS Classification (correspond to Category 5 in GHS classification), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on LD50 values of 2800 mg/kg bw (male) and >3000 mg/kg bw (female) for rabbits (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on LC50 values of 11.6 mg/L/6h (14.2 mg/L/4h) (male) and 11.1 mg/L/6h (13.6 mg/L/4h) (female) for rats (SIDS (2003)), the substance was classified as "Not classified". Since the saturated vapour pressure concentration of the substance is 25 mg/L, the test was considered to be conducted for mist from the report of the aerosol in the assessment document.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on results of "slightly irritating" (PDII: 1.4) in a rabbit test (OECD TG404) (SIDS (2003)) and "mildly irritating" (PDII: 1.7) in another rabbit Draize test (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In a rabbit test (OECD TG405), the substance was considered "slightly irritating" since 3/3 animals showed erythema and 2/3 animals showed chemosis within 1-hour, however the effects were completely reversible within 48-hour. No effects were observed in the cornea or iris (SIDS (2003)). In another rabbit Draize test, the substance was considered "moderately irritating" since irritating effects were observed within one day after application and were more severe after washing with water. The effects were completely reversible within 48-hour (SIDS (2003)). Based on the results of these two tests, the substance was classified into Category 2B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on a result of "sensitizing" in a guinea pig maximization test (OECD TG406) where the positive ratio was 95% (19/20) (SIDS (2003)), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in an intraperitoneal injection mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (SIDS (2003)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there is a report of a negative Ames test (SIDS (2003)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Based on results of a reproduction/developmental toxicity screening test by oral administration to rats (OECD TG421), fertility and developmental toxicities were found as evidenced by severely reduced pup survival, increase in time to insemination, severely reduced gestation rate, and increase in stillbirths and dead pups at a dose level at which decreased body weight gain and general signs such as hypoactivity and piloerection were observed in parent animals (SIDS (2003)). The substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It was reported that respiratory tract irritation, if severe, can progress to pulmonary edema in some cases of human health effects (HSDB (2007)). In a oral acute toxicity test in rats (dose level: 1000 to 4000 mg/kg), rapid breathing was observed prior to death, with most deaths occurring within 24-hour of dosing. LD50 values were determined to be 1840 mg/kg (female) and 2470 mg/kg (male) (SIDS (2003)). Additionally, in a rat acute inhalation (aerosol) toxicity test, upper respiratory irritation and rapid shallow breathing occurred. Most deaths occurred within 24-hour following treatment, and lung congestion was observed at necropsy at a dose level exceeding the guidance value range of Category 2 (SIDS (2003)). The effects by oral exposure to rats were observed at dose levels within the guidance value range for Category 2 (<=2000 mg/kg). The results of the inhalation test suggests strong effect on the respiratory system. Based on the report of human effects as reported in a document in List 2, the substance was classified into Category 2 (respiratory system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a repeat dose toxicity test with oral dosing to rat for 32 days (OECD TG407), the NOAEL of 150 mg/kg/day (90-day equivalent: 53.3 mg/kg/day) determined is within the guidance value range. At a higher dose rate of 750 mg/kg/day (90-day equivalent: 266.7 mg/kg/day), mortality, inflammatory changes, fibrosis and hyperplasia of bronchial epithelium in the lung and changes in blood parameters indicative of a stimulation in erythropoiesis were observed (SIDS (2003)). The higher dose exceeds the guidance value range, therefore classification was not possible due to lack of data for evidence of effects at or near the upper limit (100 mg/kg/day) guidance value range.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 24h-EC50 = 94.1 mg/L for Crustacea (Daphnia magna) (SIDS, 2005).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since it is rapidly degradable (decomposition by OECD TG301E: 69% (SIDS, 2005)) and bioaccumulation potential of its hydrolysates in estimated to be low (SIDS, 2005) though its acute toxicity is Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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