NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122453-73-0
Chemical Name	chlorfenapyr; 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethylpyrrole-3-carbonitrile
Substance ID	m-nite-122453-73-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing fluorine, chlorine, and oxygen, which are chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Its rat LD50 was documented to be 626 mg/kg in one study (EPA. PESTICIDE (2001)); in another study, it was found to be 461 mg/kg for males and 304 mg/kg for females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). All these values fall under the range of Category 4 guidance values.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since its rabbit LD50 value is > 2000 mg/kg (EPA. PESTICIDE (2001), and A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center (2008)), the substance was classified into "Not classified" (Category 5 or "Not classified" category in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on the results that its mouse LC50 values are 0.83 mg/L for males and > 2.7 mg/L for females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) and its EU Risk Phrase of R23, the substance was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	In GLP-compliant primary skin irritation tests using rabbits, the substance was documented to be not skin irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)); thus, it was classified into "Not classified". The EPA. PESTICIDE (2001) also reported similar test results.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In primary skin irritation tests using rabbits, corneal clouding, iritis, and conjunctivitis were noted after 48 hours, and all affected animals fully recovered within 7 days (EPA. PESTICIDE (2001). In addition, there the information that the substance is mildly irritating to ocular-mucous membrane (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Based on these study results, the substance was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Negative results obtained in Buehler tests using guinea pigs (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) and maximization tests using guinea pigs (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) indicate the classification of the substance into the "Not classified" category. However, since these results were acquired using List 2 datasets, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results found in in vivo mutagenicity tests using somatic cells (micronucleus tests using bone marrow cells of mice that underwent oral administration) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity studies, Ames tests, HGPRT mutation tests using CHO cells (GLP-compliant), and chromosomal aberration tests using CHL cells all yielded negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) while chromosomal aberration tests using CHO cells found positive results only at high administration doses (EPA. PESTUCIDE (2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	In chronic toxicity / carcinogenicity joint tests using rats, administration of the substance up to approximately 30 mg/kg/d for 2 years did not affect incidences of tumorigenesis, and it was found to be non-carcinogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Similarly, in carcinogenic tests using mice, administration of the substance up to approximately 35 mg/kg/d for 18 months did not affect frequencies of developing neoplastic lesions, and it was found to be non-carcinogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into the "Not classified" category; however, since they were obtained using List 2 datasets, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In 2-generation reproduction tests using rats (GLP-compliant), concentrations of mixed diet administration from 60 to 600 ppm did not affect neither fertility nor any indices related to morphological differentiation after birth (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). In addition, in oral administration tests conducted during the organogenetic period using rats (dose: 25-225 mg/kg/d), administration had no effects on any inspection items related to reproductive toxicity, and it was found to be non-teratogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Also, in oral administration tests conducted during the organogenetic period using rabbits (dose: 5-30 mg/kg/d), administration had no effects on any inspection items related to implantation and fetuses, and it was found to be non-teratogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into the "Not classified" category; however, since they were obtained using List 2 datasets, the substance was classified into "Classification not possible". The above-mentioned studies are reported by ESA. PESTICIDE (2001) as well.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In orally administered rapid neurotoxicity tests using rats (GLP-compliant), lethargy was seen in 5 out of 20 rats treated with 180 mg/kg, and 2 out of 20 rats in 90 mg/kg groups; and functional examinations found abnormal gait, dyskinesia, and lowered levels of alertness in 180 mg/kg groups (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into Category 1 (nervous system); however, since they were obtained using List 2 datasets, the substance was classified into Category 2 (nervous system). As additional information, in acute oral toxicity tests using rats (GLP-compliant), though doses administered cannot be confirmed, dyspnea or clonic convulsions were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Also, in general pathological studies using rats (Irwin method), raised body temperatures, clonic convulsions, and abnormal gait, etc. were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system, liver)	Warning	H373	P260 P314 P501	In 90-day repeated oral administration tests using rats, administration of approximately 90 to 100 mg/kg/d showed increased GPT and gamma-GTP in males, and increased gamma-GTP in females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). In 4-week repeated dermal exposure tests using rabbits, administration of 400-1000 mg/kg/d (90-day conversion: 107-270 mg/kg/d) showed no effects other than vacuolization of hepatocyte cytoplasm and an increased GPT (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). On the other hand, motor ataxia in male rats and decreased activities were reported in the above-mentioned rat tests; moderate to extensive, reversible vacuolization was detected in the cerebral cortex and optic nerves in 90-day repeated oral administration tests using mice (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)); and similar reversible neuropathy was observed in mice that received administration for 52 weeks (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Since doses used in these tests fall under the range of Category 2 guidance values, the substance was classified into Category 2 (nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 24-96-hour LC50 = 0.0061 mg/L for crustaceans (Daphnia) (HSDB, 2007), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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