NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	123-72-8
Chemical Name	butyraldehyde
Substance ID	m-nite-123-72-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point is -6.67degC (closed cup) (Merck 14th (2006) No. 1591), and its initial boiling point is 74.8degC (Merck 14th (2006) No. 1591; Ullmanns (E) 6th, 2003, vol. 5), the substance was classified into Category 2. As relevant information, also in TDG classification, since the substance fits in Class 3, Packing group II, it is classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition point is 190degC - 230degC (Chapman Ver. 16, 1 (2008); NFPA 13th, 2006; Hommel (1996)), which is above 70degC, and the substance fits in Class 3 in TDG classification (UN No. 1129), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on its LD50 values of 2490, 2500, 4160, 5890, and 5900 mg/kg bw for rats (IUCLID, 2000), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its LD50 value of 5730 microL/kg (specific gravity conversion, 4584 mg/kg) for rabbits (Patty 5th vol. 5, 2001), the substance was classified into "Not classified" in JIS classification. In addition, it fits in Category 5 in UN classification.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Given that its vapour pressure is 111 mmHg (conversion value: 14796 Pa at 25degC) (HSDB, 2003), its saturated vapour pressure concentration is calculated to be approx. 146495 ppm. In a 30-minute inhalation test using rats, its LC50 value was found to be 60000 ppm (PATTY 5th vol. 5, 2001), which was below 90% of its saturated vapour pressure concentration. Thus, the classification was conducted under the assumption that this test was carried out in a vapour with almost no included mists. Since the 4-hour LC50 is calculated to be 21213 ppm, based on the LC50 of 60000 ppm obtained in the 30-minute test, the substance falls under the"Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since it is documented that in two tests using rabbits (both tests are in compliant with OECD TG 404, GLP), the substance was either not irritating or slightly irritating (IUCLID (2000)), it was classified into the "Not classified" category using JIS classification criteria (Category 3 in UN classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Since it is described that in six instances of industrial corneal injury from butyraldehyde recovery was prompt and complete (HSDB, 2003), and in a test using rabbits according to OECD TG 405 (GLP) the substance was slightly irritating (IUCLID (2000)), it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since the substance was negative in a peripheral blood micronucleus test using mice (in vivo mutagenicity test using somatic cells) (Evaluation of effect for the food safety (Food Safety Commission), 2007), it was classified into "Not classified". As relevant information, as for in vitro tests, the substance was negative in two Ames tests (PATTY 5th vol. 5, 2001; Evaluation of effect for the food safety (Food Safety Commission), 2007), negative in a cytogenetical test using CHO cells (IUCLID (2000)), negative in a sister chromatid exchange tests using human lymphocytes (IUCLID (2000)), negative in an unscheduled DNA synthesis test using human hepatocytes (IUCLID (2000)), positive in a HGPRT test (IUCLID (2000)), positive in a sister chromatid exchange test using CHO cells (IUCLID (2000)), positive in a chromosomal aberration test using CHL/IU cells (Evaluation of effect for the food safety (Food Safety Commission), 2007), and weakly positive in an unscheduled DNA synthesis test using rat hepatocytes (PATTY 5th vol. 5, 2001).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	As for human effects, it is documented that exposure to butyraldehyde may be implicated in observed associations between the occurrence of respiratory epithelium cancer in workers and lung cancer associated with high-temperature cooking; however, coexposures with other more reactive aldehydes do not support the role of butyraldehyde acting alone (PATTY 5th vol. 5, 2001), and therefore, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Since it is reported that in humans, the substance is extremely destructive of tissues of the mucosal membranes and upper respiratory tract (PATTY 5th vol. 5, 2001), and inhalation exposures to more than 6000 ppm (17.7 mg/L, vapour) or more produce bronchial and alveolar edema in rodents (PATTY 5th vol. 5, 2001), the substance was classified into Category 1 (respiratory organ).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is documented that in a 90-day gavage administration test using rats (Evaluation of effect for the food safety (Food Safety Commission), 2007), the 300 mg/kg bw group showed slight squamous cell hyperplasia at the anterior stomach/glandular stomach border or in the anterior stomach, and in the 1200 mg/kg bw group, ulcerous lesions were observed in the anterior stomach/glandular stomach, and in males that received 300 mg/kg bw or more and females that received 600 mg/kg bw or more, inflammation was observed in the nasal cavity, and from these results, it is concluded that the NOAEL is 100 mg/kg bw and NOEL are 150 mg/kg bw for males and 300 mg/kg bw for females. Since these values of NOAEL are equal to or greater than the upper guidance value, the substance should be classified into "Not classified" (oral). However, since data on other routes are not sufficient, and due to the lack of data, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	As its 96h-LC50 is 13.4 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Although its preexisting classification for acute toxicity is Category 3, it is rapidly biodegradable (readily biodegradable, BOD degradability, 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), and it is estimated to have low bioaccumulation potency (log Kow = 0.88 (SRC, 2005)), and therefore, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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