NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	123-77-3
Chemical Name	Azodicarbonamide
Substance ID	m-nite-123-77-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Classified into Not classified since the substance is classified into Division 4.1, PG II in UNRTDG (UN3242) though there are chemical groups (aliphatic azo compound) associated with explosive properties present in the molecules. Oxygen balance is -55.13.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Category 1	Danger	H228	P370+P378 P210 P240 P241 P280	Classified into Category 1 since commercially pure azodicarbonamide is classified into Division 4.1, PG II in UNRTDG (UN3242) from which the substance is not corresponding to Self-reactive substances and mixtures.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Type G	- -	-	-	Classified into Type G since the commercially pure UN3242 does not correspond to Self-reactive substances and mixtures though there are chemical groups (aliphatic azo compound) associated with explosive properties present in the molecules. Composition of azodicarbonamide may be classified into UN3232(Type B), UN3224, 3234 (Type C), 3226 or 3236 (Type D).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	The substance does not fall into upper Division 4.2 (Substances liable to spontaneous combustion) since it is classified into Division 4.1, PG II in UNRTDG (UN3242).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a LD50 value of 6400 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2000)), no mortality at 5000 mg/kg bw (CICADs 16 (1999)) and no mortality at 6000 mg/kg bw (JECFA (1967) for rats, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >2000 mg/kg bw for rabbits (CICADs 16 (1999)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	A LC50 value of 61,000 mg/m3/4h (6.1 mg/L/4h) for rats (CICADs 16 (1999)) corresponds to "Not classified". Since the test was conducted for dry aerosol, the classification criteria for "dust and mists" was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a report that application to the skin of the auricular region of rabbits for 24-hour resulted in "not irritating", the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Based on a result of "not irritating" in a rabbit test (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, in a rabbit test where a mixture of 90% this substance and 10% benzene sulfinic acid, zinc salt was applied, redness and swelling of the conjunctivae were observed but these effects were reversible within 3 days and no corneal changes were observed (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	There is a report of a bronchial challenge test providing reasonable evidence that the work-related asthmatic symptoms were due specifically to this substance (CICADs 16 (1999)). According to this report, the delay in response to this substance challenge, the magnitude of reduction in FEV1 accompanied by an increase in airway hyperreactivity were observed in one individual, but a control individual did not respond under similar conditions. Additionally, multiple incidents showing a relationship between occupational exposure to this substance and asthma or respiratory symptoms were reported (IUCLID (2000)). Based on the above data and information, it was concluded that the key toxic effect of this substance in humans is asthmagenicity (CICADs 16 (1999)). Therefore, the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into R42 (EU-Annex I (access on July 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Since to the poor quality of the only available animal test data, it is not possible to draw any conclusions (CICADs 16 (1999)). However, since on a report of skin sensitization in a male textile worker wearing foam ear plugs, a patch test was conducted to determine the cause of recurrent dermatitis of the ear which resulted in a positive reaction to this substance (CICADs 16 (1999)). Additionally, case reports indicate that patients with dermatitis exposed to this substance at the work place showed a positive reaction with this substance (IUCLID (2000)). Therefore it is concluded that the substance should be considered as a human skin sensitizer (CICADs 16 (1999)), and the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in an intraperitoneal injection mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (CICADs No.16 (1999)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of a positive Ames test (NTP DB (access on Jul. 2009)), a positive CHO cell chromosomal aberration test (NTP DB (access on Jul. 2009)) and a negative mouse lymphoma (L5178Y cell) test (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a one-generation reproduction toxicity test by oral administration to rats (OECD TG415 (GLP)), no effects were found in males. Death during the lactation period due to pelvic nephritis-like lesions occurred in the high dose female group (1000 mg/kg). No adverse effects on reproductive parameters of parent animals and viability, growth and morphology of offspring were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2000)). However, since data for developmental toxicity including teratogenicity are insufficient, classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Since no adverse effects were observed by oral administration at 6000 mg/kg to rats or mice (JECFA (1967)), the substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of or insufficient data with other exposure routes.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Reported NOELs in 13-week oral tests are 1000 mg/kg/day for female rats, 2500 mg/kg/day for male mice and 2500 mg/kg/day for female mice (IUCLID (2000)). Additionally, it was reported that no toxicological significant changes were observed at the highest dose of 0.2 mg/L in 13-week inhalation (aerosol) tests with rats and mice (CICADs 16 (1999)). There were no adverse effects by oral administration at 100 - 1000 mg/kg/day for 8 weeks (90-day equivalence: 60 - 600 mg/kg) to rats (JECFA (1967)). The substance corresponds to "Not classified" with oral and inhalation exposure since NOELs or levels without observed adverse effect exceed the upper limit of the guidance value range for Category 2. However, classification was not possible due to lack of dermal exposure data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 (immobile) = 11 mg/L for crustacea (Daphnia magna) (WHO CICAD: 1999, OECD SIDS: 2001).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (J-CHECK, 1977)), and 72-hour NOEC (growth rate) = 7.2 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS: 2001). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (J-CHECK, 1977)), and 48-hour EC50 (immobile) = 11 mg/L for crustacea (Daphnia magna) (WHO CICAD: 1999, OECD SIDS: 2001). From the above results, it was classified in Category 3.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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