Item | Information |
---|---|
CAS RN | 124-04-9 |
Chemical Name | Adipic acid |
Substance ID | m-nite-124-04-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 420 deg C (SIDS (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are 5 reports of LD50 values of 940 mg/kg, 3,615 mg/kg (ACGIH (7th, 2001)), 5,050 mg/kg (HPVIS (2008)), 5,560 mg/kg (SIDS (2006)), and >11,000 mg/kg (PATTY (6th, 2012)) for rats. It was classified as "Not classified" (3 cases) to which the largest number of data corresponds based on the revision of the GHS classification guidance for the Japanese Government. Besides, one case corresponds to Category 4, and one case to "Not classified" (Category 5 in UN GHS classification). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of >7,940 mg/kg (converted value to pure substance: >3,176 mg/kg) as an LD50 value for rabbits using corn oil (40% concentration of this substance) (SIDS (2006), HPVIS (2008)), it was classified as "Not classified." New information sources (SIDS (2006), HPVIS (2008)) were added, and the classification was revised. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on a report of an LC0 value (4 hours) of 7.7 mg/L (SIDS (2006), HPVIS (2008)) for rats, it was classified as "Not classified." Besides, since the LC0 value is higher than the saturated vapor concentration (0.57 mg/L), the reference value as the dust was applied. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In a skin irritation test with rabbits, reversible redness and edema were observed, and the irritation score was 2.21 (SIDS (2006)). Other than this, slight irritation was observed in skin irritation tests with rabbits and guinea pigs (SIDS (2006), BUA 68 (1991)). In addition, there is a report that it exerts a drying action on the skin and may cause dermatitis in humans (ACGIH (7th, 2001)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was revised according to the revision of the GHS classification guidance for the Japanese Government. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Corneal opacity (score 1-3) was observed in an eye irritation test (OECD TG 405) with rabbits (SIDS (2006)). In addition, in another eye irritation test with rabbits, mean scores of cornea reaction, iritis, conjunctivitis, and conjunctival edema were reported as 1.33, 0.83, 2, 2, respectively (SIDS (2006)). From the above results, it was classified in Category 2A. Besides, this substance was classified as "Xi; R36" in the EU DSD classification, and as "Eye Irrit. 2 H319" in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that two workers handling adipic acid developed bronchial asthma although details are unknown (PATTY (6th, 2012), ACGIH (7th, 2001)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that there was no skin sensitization in a test with guinea pigs (SIDS (2006), PATTY (6th, 2012)), but the information was judged to be inadequate for classification for the following reasons: There was no positive control group, no adjuvant was used, etc. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a dominant lethal test with rats, and a negative result is reported in a chromosomal aberration test with bone marrow cells of rats (SIDS (2006), ACGIH (7th, 2001), HPVIS (2008), JECFA FAS 12 (1977), PATTY (6th, 2012)). As for in vitro, it was all negative in bacterial reverse mutation tests, and a mouse lymphoma test and a chromosomal aberration test with cultured mammalian cells (SIDS (2006), ACGIH (7th, 2001), HPVIS (2008), JECFA 12 (1977), PATTY (6th, 2012)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There are no carcinogenicity classifications by international organizations. There is a report in SIDS (2006) that no carcinogenicity was observed in a 2-year feeding study with rats (male: dose at or less than 5% (3,750 mg/kg bw/day), female: dose at 1% (750 mg/kg bw/day)), but it is reported that this study is information with limitation because other than being non-GLP, the number of animals and the organs examined were few, the number of animals used for histopathological examination was unknown, and so on. In addition, it is also reported in PATTY (6th, 2012) that there was no evidence of carcinogenicity in a 2-year study with rats, but there is not enough information. Moreover, also in BUA (1991), there is a description of a 2-year study with rats. From the above, it was classified as "Classification not possible" due to lack of data on this substance as a whole. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No teratogenicity was observed in teratogenicity tests with rats, mice, and rabbits by the oral route (SIDS (2006), JECFA FAS12 (1977), ACGIH (2001), PATTY (6th, 2012)), but since information on fertility is not obtained, it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In humans, there are reports of functional disorders of the autonomic nervous system, gastrointestinal tract, and upper respiratory tract mucosa, irritation of the nasal mucosa by inhalation exposure of workers to the dust of this substance and aggravation of asthmatic reactions and slight burning sensations of the respiratory organs by inhalation exposure to a solution of this substance (ACGIH (7th, 2001), SIDS (2006), PATTY (6th, 2012)). In rats, effects of irritation and bleeding due to this substance such as acute dilatation of the heart in dead animals, acute congestive hyperaemia and ulceration of the glandular stomach (corrosive gastritis) were observed at doses exceeding the guidance value in the oral route, but there were no signs of toxicity in the inhalation route and occlusive dermal application (SIDS (2006), HPVIS (2008)). From the above, it was classified in Category 3 (respiratory tract irritation). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In the oral route, no symptoms of toxicity were observed even by oral administration of 100 mg/kg/day to human volunteers for 10 days, and in a study in which this substance was administered by feeding to rats for 2 years, only decreased body weight gain was observed at higher doses (2,250 mg/kg/day (converted value described in SIDS (2006))) corresponding to "Not classified" (calculated as 2,250 mg/kg/day in SIDS (2006)) (SIDS (2006), ACGIH (1977), JECFA FAS 12 (7th, 2001), HPVIS (2008)). Therefore, it is judged as equivalent to "Not classified." As for the inhalation route, there is a description that rats were exposed to the dust of this substance at a concentration of 0.126 mg/L for 6 hours/day, 5 days/week for 3 weeks (converted guidance value: 0.021 mg/L), but no abnormality was observed (ACGIH (7th, 2001)), but including this test, no inhalation exposure test covering the range up to Category 2 was conducted, and no data are available for classification. Therefore, this substance is equivalent to "Not classified" for the oral route, but there are no data available for classification for inhalation and dermal routes. Therefore, it was classified as "Classification not possible" due to lack of data. Besides, in the previous classification, it was classified in Category 1 (autonomic nervous system) from the description that in worker who inhaled the dust of this substance, effects on the autonomic nervous system were observed, however, since it was confirmed in ACGIH (7th, 2001) and PATTY (6th, 2012) that the corresponding descriptions were effects from single exposure and effects at concentrations causing irritation to the eyes, it was excluded from this classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 48-hour EC50 = 46 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD = 85, 68, 90% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 21-day NOEC = 6.3 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD = 85, 68, 90% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and a low bioaccumulation estimate (log Kow = 0.08 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 97 mg/L for fish (Pimephales promelas) (SIDS, 2004). From the above results, it was classified as "Not classified." |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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