NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	124-18-5
Chemical Name	Decane
Substance ID	m-nite-124-18-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of 46 deg C (closed-cup) (ICSC(J) (1998)), it was classified in Category 3. Besides, it is classified in Class 3, PG III (UN 2247) in UNRTDG.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 210 deg C (ICSC(J) (1998)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, there is a reported LD50 value (OECD TG 401) of > 5,000 mg/kg for rats (ECHA Dossier (Access on January 2017)) which is equivalent to "Not classified." However, it is not possible to classify the substance based on only this value since the information source of the data is not on the List 1, List 2 and List 3. In addition, because IUCLID (2000) data used in the previous classification were not available, and details were unknown, it was not adopted as the evidence for classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, because IUCLID (2000) data used in the previous classification were not available, and details were unknown, it was not adopted.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on the 2-hour LC50 value of 72.3 mg/L (converted 4-hour equivalent value: 36.2 mg/L) for mice (PATTY (6th, 2012)), this substance was classified as "Not classified." Besides, since the LC50 is higher than the saturated vapor pressure concentration (1,887.3 ppm (converted value: 11.0 mg/L)), a reference value in the unit of mg/L was applied as mist.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, in skin irritation tests using rabbits (2 tests including the OECD TG 404 test), slight irritation was found (GESTIS (Access on September 2016)), therefore, it is thought that the test result was equivalent to "Not classified" (Category 3 of UN GHS classification). However, the details of the tests were unknown because the original literature could not be confirmed, and so on. Thus, it was not adopted as the evidence for classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, in eye irritation tests using rabbits (2 tests including the OECD TG 405 test), irritation was very slight (maximum irritation index 1 for irritation of the conjunctiva after 24 and 48 hours) (GESTIS (Access on September 2016)), therefore, it is thought that this test result was equivalent to "Not classified." However, the details of the tests were unknown because the original literature could not be confirmed, and so on. Thus, it was not adopted as the evidence for classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　There is no in vivo data. As for in vitro tests, a bacterial reverse mutation test was negative (NTP DB (Access on September 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, in a study where the substance alone or in combination with Benzo[a]pyrene (BP) was applied to the skin of female mice for 440 days (3 times/week), skin papilloma was observed in 38 of 50 cases in the combination administration group (this substance 25 mg + BP 5 microg), while it was observed in 12 of 50 cases in the group of BP alone, and in 1 of 50 cases in the group of this substance alone. 　An increase in the incidence of papilloma in the combination group suggested that this substance might have promoter activity (NTP Summary of Data for Chemical Selection (Access on September 2016), PATTY (6th, 2012)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no developmental and reproductive effects were observed both in parent and child animals at up to 1,000 mg/kg/day (SIAP (2012)). 　However, it is difficult to classify as "Not classified" based only on this screening test result, and no other data were available for classification. Therefore, the classification in this hazard class was not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　As for effects in humans, it is described that this substance shows asphyxia and causes central nervous system depression in very high concentrations (HSDB (Access on Sep 2016), PATTY (6th, 2012)). 　Since central nervous system depression might be due to oxygen deficiency, it was not used as a basis for classification. 　In addition, also in GESTIS (Access on September 2016) which is the information source on List 3, it is described that following high doses, symptoms of central nervous system depression could occur. However, no original literature was not available and no detail could be confirmed. There is no information available for the evidence of classification regarding experimental animals. Therefore, this substance was classified as "Classification not possible."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no information on humans. 　As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no effects were observed at the highest dose of 1,000 mg/kg/day (SIAP (2012)). In addition, in a 57-day (18 hours/day) toxicity study using rats administered by inhalation, decrease in the white blood cell count was observed at 540 ppm (3.14 mg/L) (converted guidance value: 5.97 mg/L), but no bone marrow changes or other organ changes were noted (PATTY (6th, 2012)). In a 50-week (3 days/week) study using mice administered dermally at doses of 0.1 to 0.15 g/animals, fibrosis of the dermis, pigmentation, and ulceration, and in a few cases kidney effects and lung hemorrhaging were observed (PATTY (6th, 2012)). However, these findings were seen at the doses outside the range of Category 2. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	This substance is a hydrocarbon. 　Since its calculated kinematic viscosity value based on numerical data (viscosity: 0.838 mPa*s (25 deg C), density: 0.73 g/cm3 (20 deg C)) listed in HSDB (Access on September 2016) is 1.15 mm2/sec (25/20 deg C), this substance was classified in Category 1. 　Besides, it is described in GESTIS (Access on September 2016) that even if low doses of this substance are swallowed, there is a risk of serious lung damage as a consequence of aspiration. In addition, it is described that, in a test using rats, the aspiration of 0.2 mL of this substance caused death within 24 hours as a consequence of pulmonary edema (GESTIS (Access on September 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	The classification is not possible because appropriate data are not obtained.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	The classification is not possible because appropriate data are not obtained.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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