NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	126-99-8
Chemical Name	2-Chloro-1,3-butadiene
Substance ID	m-nite-126-99-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 2 since flash point -20 degC (Hommel (1996)) is <23 degC and initial boiling point 59 degC (NFPA (13th, 2002)) is >35 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Type G	- -	-	-	Classified into Type G since the substance containing stabilizers (hydroquinone or phenothiazine) is classified into Class 3, Subsidiary risk 6.1 PG I in UNRTDG (UN1991) though there are chemical groups (unsaturated C=C)) associated with self-reactive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 440 degC (Hommel (1996)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains chlorine (but not oxygen) which is chemically bonded only to carbon.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on LD50 values of 251 mg/kg and 450 mg/kg for rats (SIDS (1998)), the lower value was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Based on a LD50 value of 200 mg/kg for rats (SIDS (1998)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on LC50 values of 11.8 mg/L (3259 ppmV) (SIDS (1998)) and 8.2 mg/L (2264 ppmV) (IARC 19 (1979)) for rats, the lower value was adopted and the substance was classified into Category 3. Since saturated vapour pressure concentration was 282,895 ppmV, the classification criteria for gas was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a report that after occlusive application to the skin of rabbits, mild to moderate erythema with edema was observed at 24-hour, and mild to moderate erythema persisted until 48-hour (SIDS (1998)), the substance was classified into Category 2. As relevant information, the substance is classified into Xi; R36/37/38 in EU classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a report that conjunctivitis lasted for 10 days in a rabbit test (SIDS (1998)) and classification as Xi; R36/37/38 in EU classification, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	There are conflicting results (positive at low concentrations and negative in high concentrations) in dominant lethal tests by inhalation exposure to mice and rats (in vivo heritable germ cell mutagenicity test) (SIDS (1998)). In addition, the results of mouse and rat bone marrow chromosomal aberration tests and micronucleus tests (in vivo somatic cell mutagenicity tests) are contradictory (SIDS (1998)). A possible explanation for the positive results may be presence of unknown impurities in the test substance. Additional investigations are required to evaluate the germ cell mutagenicity of the substance (SIDS (1998)). Classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Based on the classification of "Group 2B" in IARC (IARC 71 (1999)), the substance was classified into Category 2. In 2-year inhalation tests in rats and mice (NTP TR467 (1998)), the incidences of neoplasms were significantly increased in the oral cavity, thyroid gland, lung, kidney and mammary gland of rats, and the lung, circulatory system, Harderian gland, forestomach, skin and mammary gland of mice. The substance is classified into "Reasonably anticipated to be a human carcinogen" in NTP (NTP ROC 11th (2000)). Additionally, the substance is classified into Category 2 in EU classification, however, the EU classification was not used for GHS classification since the evidence supporting the classification is not available. Classification in DFG (MAK) is Category 2 (Substances that are considered to be carcinogenic for man) (MAK/BAT (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Meningoencephaloceles was observed in rats following inhalation or oral exposure during gestation (IARC 19 (1979)). An increase in resorptions, increased embryo toxicity and teratogenic effects (reduced length of the diaphase of the femur and fibula, hydrocephalus) were observed following inhalation exposure (SIDS (1998), ACGIH (2001)). Exposure to male rats and mice resulted in sterility or impotence (ACGIH (2001)). There are marked disparities among reported test results, therefore, the weight of evidence for teratogenicity and reproductive toxicity is very limited and insufficient (ACGIH (2001)). The substance was classified into Category 2 since there is no sufficient evidence to classify it in Category 1. On IARC monographs (1979), cases of children born with physical and mental defects are reported for women working in a chloroprene factory. Additionally, a threefold excess of miscarriage by the wives of workers occupationally exposed to chloroprene were reported (IARC 19 (1979)). These findings are not found in other IARC monographs (1999). This same data are reported in other documents (ACGIH (2001) and NTP TR467 (1998)), however, these documents reported that the methods used to gather data in these tests were questioned. In addition, there is a report in SIDS (1998) that there were not enough reliable data available to draw meaningful conclusions for the substance. These human case reports were not used as the basis of classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Liver injury was observed in rats exposed via inhalation to 225 ppm (0.810 mg/L) and higher concentrations (IARC 71 (1999)). In another test, markedly more hepatotoxicity with increased hepatic enzyme activity was reported at 500 ppm (1.810 mg/L) and higher concentrations (IARC 71 (1999)). Oral administration to rats produced CNS depression (PATTY (5th, 2001)). In rats respiratory failure by inhalation exposure was reported (IARC 71 (1999)). In humans, there is a report that the symptoms of acute inhalation exposure include nervous system depression, and injury to the lungs, liver and kidney (IARC 71 (1999)), but there is no report of detailed symptoms of CNS depression or a report associated with narcotic effects. Since the above effects were observed in rats at dose levels within the guidance value range for Category 1 and the effects were also observed in human cases, the substance was classified into Category 1 (central nervous system, respiratory system, liver, kidney).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, blood, nervous system, stomach, respiratory system, cardiovascular system)	Danger	H372	P260 P264 P270 P314 P501	Because following inhalation exposure to rats for 4-week, midzonal liver degeneration and necrosis were noted at a dose level of 160 ppm (0.579 mg/L, 90-day equivalence: 0.178 mg/L) and higher concentrations which are within the guidance value range for Category 1 (PATTY (5th, 2001)), the substance was classified into Category 1 (liver). Additionally, there are other reports of liver toxicity: a significant increase in the incidence of hepatocellular necrosis in rats following inhalation exposure to 200 ppm (0.724 mg/L) for 13-week (NTP TR467 (1998)) and observation of liver damage or jaundice in dogs and guinea pigs exposed via inhalation (SIDS (2009)). For the blood system, inhalation exposure of rats for 13-week at concentration of 200 ppm (0.724 mg/L) produced normocytic, normochromic anemia (NTP TR467 (1998)), and inhalation exposure of mice for 13-week at concentrations of 32 ppm (0.116 mg/L) and higher produced significant decreases in hematocrit values and erythrocyte counts and a change in platelet counts (IARC 19 (1979)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (blood system). For the nervous systems, 44% of patients with chronic chloroprene poisoning had pathological changes in the (cardiovascular and) nervous systems and symptoms such as dizziness and insomnia were reported (IARC 19 (1979)). It was reported that decreased blood cholinesterase activity occurred due to occupational exposure (IARC 19 (1979)). In rats, symptoms such as low motor activity, restlessness and lethargy were observed following exposure. Based on the information, the substance was classified into Category 1 (nervous systems). For the stomach, in a 13-week inhalation test in mice (NTP TR467 (1998)), increased incidences of squamous epithelial hyperplasia of the forestomach occurred at dose levels of 80 ppm (0.290 mg/L) and higher concentrations. Additionally, there is a report that chronic exposure may result in gastrointestinal disorders (IARC 19 (1979)). Based on the information, the substance was classified into Category 1 (stomach). For the respiratory system, inhalation exposure to rats for 4-week (PATTY (5th, 2001)) induced tissue damage to the lung at dose levels of 160 ppm (0.579 mg/L, 90-day equivalence: 0.178 mg/L) and higher concentrations which are within the guidance value range for Category 1. In a 13-week inhalation test in rats (NTP TR467 (1998)), increased incidences of olfactory epithelial degeneration and respiratory metaplasia occurred at dose levels of 80 ppm (0.290 mg/L) and higher concentrations. Additionally, there is a report that chronic exposure may result in respiratory irritation. Based on the information, the substance was classified into Category 1 (respiratory system). For the cardiovascular system, based on a human case report that 44% of patients with chronic chloroprene poisoning had pathological changes in the cardiovascular and dystrophy of the myocardium (NTP TR467 (1998)), the substance was classified into Category 1 (cardiovascular system). Findings for the immune system were not used as the basis of classification, since the information was found in IARC monographs (1979) but not in other IARC monographs (1999) or other documents. The findings for the tooth/periodontal tissue were not used as the basis for classification since this information is only found in IARC 19 (1979) and introduction of NTP TR467 (1998) and not in other documents.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified into Not classified from its 96h-LC50 = 245 mg/L for fish (Bluegill) (SIDS, 2003) and 48h-EC50 = 348 mg/L for Crustacea (Daphnia magna) (SIDS, 2003).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 874.9 mg/L (PHYSPROP Database, 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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