NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	130-15-4
Chemical Name	1,4-Naphthoquinone
Substance ID	m-nite-130-15-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on LD50 values of 190 mg/kg bw and >300 mg/kg bw for rats (BUA 211 (1998)), the lower value (190 mg/kg bw) was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a LC50 value of 0.046 mg/L/4h for rats (BUA 211 (1998)), the substance was classified into Category 1. Since the LC50 value was higher than saturated vapour pressure concentration (0.001439 mg/L), the test was considered to be conducted for dust.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on results of "highly irritating" or "severe irritation" in rabbit tests (BUA 211 (1998)), reports of skin irritating in occupationally exposed workers (BUA 211 (1998)), and a report that human skin contact with the wet powder may cause highly irritating or corrosion and subsequently the injury may gradually resolve without complication (BUA 211 (1998)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on results of "highly irritating" or "severe irritation" in rabbit tests (BUA 211 (1998)) and reports that "severe irritating" to the eye were observed after exposure in human (BUA 211 (1998)), the substance was classified into Category 2A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	Although there are results showing positive reactions in a guinea pig respiratory sensitization tests (BUA Report No. 211 (1998)), it is reported that evaluation of the respiratory sensitization was impossible since the data processing and reporting were not adequate and observed reactions may be attributed to irritation (BUA Report No. 211 (1998)). Classification was not possible due to lack of sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	Although sensitizing results in a guinea pig skin sensitization test are reported (BUA 211 (1998)), classification was not possible since the information is reported in a document in List 2 and the test method is not approved by OECD.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in an oral Chinese hamster bone marrow chromosome aberration test (in vivo somatic cell mutagenicity tests) (BUA 211 (1998)), the substance was classified as "Not classified". From in vitro mutagenicity tests, there are reports of negative Ames tests and gene mutation test (HGPRT assay) (BUA 211 (1998)) but a positive chromosomal aberration test (BUA 211 (1998)). As relevant information, the substance is an existing chemical substance, for which mutagenicity was established (Kiankahatsu No. 0827010, August 27, 2004) under the provisions of Article 57-3 of the Industrial Safety and Health Law.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although there is a reported that no effect on pregnancy was noted in an oral administration test with mice during gestation days 6 - 12 (BUA 211 (1998)), the test was conducted in an earlier time (in 1958), the dosage levels were not clear and no data for fertility were indicated. Therefore, classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (blood system, liver), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	Based on a result that oral 500 mg/kg exposure of rats resulted in the formation of methemoglobin followed by the appearance of Heinz bodies and development of hemolytic anemia, the substance was classified into Category 2 (blood system). Additionally, since hepatocellular vacuolization and necrosis in a rat inhalation test (0.021 - 0.065 mg/L) and centrilobular hemorrhagic necrosis in a rat oral test (100 - 300 mg/kg) were reported as histopathological findings in dead animals (BUA 211 (1998)), the substance was classified into Category 2 (liver). Although some of these results correspond to Category 1 based on guidance value range, it was classified into Category 2 because of information in List 2. Additionally, respiratory tract irritation for human was reported and it was concluded that the substance caused severe irritation to the upper respiratory tract. Irritating lesions in the lung were observed in a mouse inhalation test based on decreased respiratory rate without histopathological change (BUA 211 (1998)), Based on all information, the compound was classified into Category 3 (respiratory tract irritation).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver)	Warning	H373	P260 P314 P501	A decreased number of erythrocytes in the blood, depressed phagocytic activity of leukocytes and decreased hemoglobin levels in the blood as well as appearance of methemoglobin and Heinz bodies in the blood were reported as human effect (HSDB (2006)). In a rat 6-month inhalation (dust) test (4-hour/day), the findings of hepatic dysfunction such as positive thymol test, decreased glycogen level and degeneration of hepatic parenchyma cell were observed at concentrations of 0.7 mg/m3/4 hr (0.0005 mg/L/6 hr) and higher (BUA 211 (1998)). Additionally, hepatotoxicity is reported as human toxicity excerpts (HSDB (2006)). Since the blood system and liver are regarded as target organs and these information are reported in a document in List 2, the substance was classified into Category 2 (blood system, liver). Although changes in hematological parameters including formation of methemoglobin and central nervous system disorder were observed in a rat 30-day oral test (BUA 211 (1998)), this information is not used as the basis of classification since data for the protocol and results are insufficient and there is a comment that this test is inadequate to evaluate systemic effects (BUA 211 (1998)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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